Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma
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Issue Date
2019-03-22Author
Zimmerman, Matthew
McDonald, Stacey L.
Ho-Liang, Hsin-Pin
Porubsky, Patrick
Nguyen, Quyen
Pharr, Cameron W.
Perkowski, Andrew J.
Smith, Robert
Schoenen, Frank J.
Gold, Ben S.
Zhang, David
Nathan, Carl F.
Dartois, Véronique
Aubé, Jeffrey
Publisher
Springer Nature
Type
Article
Article Version
Scholarly/refereed, author accepted manuscript
Rights
© The Author(s) 2019.
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Show full item recordAbstract
A systematic study of the stability of a set of cephalosporins in mouse plasma reveals that cephalosporins lacking an acidic moiety at C-2 may be vulnerable to β-lactam cleavage in mouse plasma.
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This work is licensed under a Creative Commons Attribution 4.0 International License.
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Citation
Zimmerman, M., McDonald, S. L., Ho-Liang, H. P., Porubsky, P., Nguyen, Q., Pharr, C. W., Perkowski, A. J., Smith, R., Schoenen, F. J., Gold, B. S., Zhang, D., Nathan, C. F., Dartois, V., & Aubé, J. (2019). Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma. The Journal of antibiotics, 72(6), 469–475. https://doi.org/10.1038/s41429-019-0167-y
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