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Chemistry: Recent submissions
Now showing items 141-160 of 964
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Time-Delayed Integration–Spectral Flow Cytometer (TDI-SFC) for Low-Abundance-Cell Immunophenotyping
(American Chemical Society, 2019-02-28)We describe a unique flow cytometer (TDI-SFC) for the immunophenotyping of low-abundance cells, particularly when cell counts are sample-limited and operationally difficult for analysis by fluorescence microscopy (>100 ... -
Desymmetrization of Cyclopropenes via the Potassium-Templated Diastereoselective 7-exo-trig Cycloaddition of Tethered Amino Alcohols toward Enantiopure Cyclopropane-Fused Oxazepanones with Antimycobacterial Activity
(American Chemical Society, 2018-04-26)A strain-release-driven, cation-templated intramolecular nucleophilic addition of tethered alkoxides to prochiral cyclopropenes is described. Employment of chiral β- and γ-amino alkoxides allowed for highly diastereoselective ... -
Kinetic, Spectroscopic, and Computational Insight into the Proton-Coupled Electron Transfer Reactivity of Manganese Complexes Supported by Pentadentate Ligands
(University of Kansas, 2018-12-31)In biological systems, manganese enzymes have been shown to perform vital proton-coupled electron transfer (PCET) reactions. In manganese lipoxygenase, a mid-valent MnIII-hydroxo moiety is proposed to abstract a hydrogen ... -
Direct and Indirect Probing of Higher-Lying Excited-States of Photoactive Molecules
(University of Kansas, 2018-12-31)It is often assumed that optically accessible excited-states above S1 play only a marginal role in the photochemistry and photodynamics of molecular systems. However, many classes of molecules have been found in which the ... -
Characterization and Thermodynamic Analysis of a Series of MnIII-OH Complexes that undergo Hydrogen Atom Transfer Reactions
(University of Kansas, 2018-12-31)Abstract Mononuclear MnIII-hydroxo motifs employ hydrogen atom transfer (HAT) reactions in biology and synthetic systems to oxidize a wide range of CH or OH bonds. Extensive studies on high valent Fe and Mn model systems ... -
The Design and Synthesis of β-Keto Vinyl Sultams and Macrocyclic β-Keto Vinyl Sultams: Novel Analogs of Tetramic Acids
(University of Kansas, 2018-08-31)Sulfur (S)-containing heterocyclic compounds possessing R1R2N–SO2R3 functionality have been recognized as important due to their innate physical properties that affect biological systems marking them as attractive targets ... -
Kinetic and Spectroscopic Investigation of Structural Influences on Hydrogen-atom Transfer Reactivity of N5-Ligated Oxomanganese(IV) Complexes
(University of Kansas, 2018-05-31)High valent iron- and manganese-oxo intermediates perform important hydrogenatom transfer (HAT) reactions in both biological and synthetic systems. There has been extensive characterization of HAT reactivity of enzymatic ... -
Synthesis and Characterization of Antigen-Containing Bioconjugates Used to Probe and Modulate Autoimmunity
(University of Kansas, 2018-12-31)Autoimmune diseases afflict a significant part of the world population and current treatments only treat symptoms or delay the progression of the disease. In the first chapter of this dissertation, an introduction into ... -
ADENYLATION AND TAILORING ACTIVITIES IN THE NONRIBOSOMAL PEPTIDE SYNTHESIS OF THE SIDEROPHORE PYOCHELIN
(University of Kansas, 2018-12-31)Pathogenic bacteria are becoming increasingly resistant to antibiotics. In response to this alarming trend, the scientific community must determine therapeutic targets. Essential nutrients, such as iron, are necessary for ... -
Stereoselective Additions to Cyclopropenes
(University of Kansas, 2018-05-31)This thesis concerns strain-release driven stereoselective addition reactions to cyclopropenes leading to the synthesis of medium-sized 8-membered 1,5-dioxocane ring structures, optically active cyclopropylboronates, and ... -
Neurochemical methods for the sub-second measurement of neurotransmitter release
(University of Kansas, 2017-12-31)This dissertation is a compilation of work on the development of new methods and models to study neurochemical changes. Using fast-scan cyclic voltammetry to measure electroactive species is the common theme that ties these ... -
Measurements of neurotransmitter release in animal models of the central nervous system using fast scan cyclic voltammetry
(University of Kansas, 2017-12-31)This dissertation is a compilation of the work we have done in the past five years using fast-scan cyclic voltammetry in model organisms to solve biological problems. In this work, we use fast-scan cyclic voltammetry to ... -
MS/MS ANALYSIS OF IgG3 DISULFIDE BONDS AND DEVELOPMENT OF A NOVEL TOOL TO ASSESS ALGORITHMS THAT ASSIGN GLYCOPEPTIDE CID DATA
(University of Kansas, 2017-12-31)With the rapidly increasing use of proteins as biotherapeutics to treat diseases, the characterization of these large molecules using mass spectrometry has become a highly attractive field of research. A particular area ... -
Synthesis of Cyclopropane-Fused 1,5-Diazocin-2-ones via Metal-Templated Intramolecular Addition of Nitrogen Nucleophiles to Pre-Generated Cyclopropenes
(University of Kansas, 2018-08-31)This thesis is concerned with the development of methods by which to access compounds possessing the 3,4-cyclopropane-annulated 1,5-diazocin-2-one scaffold. The methods described herein are based on the intramolecular ... -
Graphene Oxide Microelectrodes for Detection of Hydrogen Peroxide
(University of Kansas, 2017-05-31)Hydrogen peroxide is a membrane-permeable reactive oxygen species (ROS) and a neuromodulator. Here, we enhanced the electrochemical detection of hydrogen peroxide by modifying a carbon-fiber microelectrode by dip-coating ... -
The fusion curves for the systems ammonia-propyl alcohols, ammonia-butyl alcohols
(University of Kansas, 1929)Baume and Perrot used the Phase law method to investigate the system CH3OH + NH3. Broderson used the same method with the system C2H5OH + NH3. Baume and Perrot found that the compound CH3.OH.NH3 was formed in the ammonia ... -
Some studies of binary and ternary systems of nitrates in anhydrous acetic acid
(University of Kansas, 1935) -
On the constitution of disubstituted isothiohydantions
(University of Kansas, 1930) -
The anodic oxidation of aluminum in liquid ammonia
(University of Kansas, 1951) -
The reaction of Reissert compounds with Grignard reagents
(University of Kansas, 1952)