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Pharmaceutical Chemistry Scholarly Works: Recent submissions
Now showing items 141-160 of 358
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Pulmonary delivery of vancomycin dry powder aerosol to intubated rabbits
(American Chemical Society, 2015-08-03)TGX-221 is a potent, selective, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit. Recent studies showed that TGX-221 has anti-proliferative activity against PTEN-deficient tumor cell lines including ... -
Prodrug Strategy for PSMA-targeted Delivery of TGX-221 to Prostate Cancer Cells
(American Chemical Society, 2012-06-04)TGX-221 is a potent, selective, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit. Recent studies showed that TGX-221 has anti-proliferative activity against PTEN-deficient tumor cell lines including ... -
Polyarginine Molecular Weight Determines Transfecion Efficiency of Calcium Condensed Complexes
(American Chemical Society, 2013-05-06)Cell penetrating peptides (CPPs) have been extensively studied in polyelectrolyte complexes as a means to enhance the transfection efficiency of plasmid DNA (pDNA). Increasing the molecular weight of CPPs often enhances ... -
Metal-Catalyzed Oxidation of Protein Methionine Residues in Human Parathyroid Hormone (1-34): Formation of Homocysteine and a Novel Methionine-Dependent Hydrolysis Reaction
(American Chemical Society, 2013-02-04)The oxidation of PTH(1-34) catalyzed by ferrous ethylenediaminetetraacetic acid (EDTA) is site-specific. The oxidation of PTH(1-34) is localized primarily to the residues Met[8] and His[9]. Beyond the transformation of ... -
Mapping Site-Specific Changes that Affect Stability of the NTerminal Domain of Calmodulin
(American Chemical Society, 2012-04-02)Biophysical tools have been invaluable in formulating therapeutic proteins. These tools characterize protein stability rapidly in a variety of solution conditions, but in general, the techniques lack the ability to discern ... -
Light-induced Conversion of Trp to Gly and Gly Hydroperoxide in IgG1
(American Chemical Society, 2013-03-04)The exposure of IgG1 in aqueous solution to light with λ = 254 nm or λ > 295 nm yields products consistent with Trp radical cation formation followed by αC-βC cleavage of the Trp side chain. The resulting glycyl radicals ... -
Iodinated NanoClusters as an inhaled CT contrast agent for lung visualization
(American Chemical Society, 2010-08-02)Author's Pre-print: grey tick subject to Restrictions below, author can archive pre-print (ie pre-refereeing) Restrictions: Must obtain written permission from Editor Must not violate ACS ethical ... -
Influence of the Valine Zipper Region on the Structure and Aggregation of the Basic Leucine Zipper (bZIP) Domain of Activating Transcription Factor 5 (ATF5)
(American Chemical Society, 2012-11-05)Protein aggregation is a major problem for biopharmaceuticals. While the control of aggregation is critically important for the future of protein pharmaceuticals, mechanisms of aggregate assembly, particularly the role ... -
Imbuing Aqueous Solubility to Amphotericin B and Nystatin with a Vitamin
(American Chemical Society, 2011-02-07)Aqueous solubilities of many drugs in current clinical use are very low, necessitating formulations that often present problems for parenteral administration, including toxicities due to the excipients used. Recognizing ... -
Identification of oxidation sites and covalent cross-links in metal catalyzed oxidized interferon beta-1a: potential implications for protein aggregation and immunogenicity
(American Chemical Society, 2013-06-03)Oxidation via Cu2+/ascorbate of recombinant human interferon beta-1a (IFNβ1a) leads to highly immunogenic aggregates, however it is unknown which amino acids are modified and how covalent aggregates are formed. In the ... -
Hyaluronic acid graft polymers displaying peptide antigen madulate dendritic cell response in vitro
(American Chemical Society, 2014-01-06)A novel oxime grafting scheme was utilized to conjugate an ICAM-1 ligand (LABL), a cellular antigen ovalbumin (OVA), or both peptides simultaneously to hyaluronic acid (HA). Samples of HA only and the various peptide grafted ... -
Enchancement of Drug Absorption through the Blood Brain Barrier and Inhibition of Intercellular Tight Junction Resealing b E-cadherin Peptides
(American Chemical Society, 2011-02-07)E-cadherin-mediated cell-cell interactions in the zonula adherens play an important role in the formation of the intercellular tight junctions found in the blood-brain barrier. However, it is also responsible for the low ... -
Solution Structure of A Novel T-cell Adhesion Inhibitor Derived from the Fragment of ICAM-1 Receptor: Cyclo(1,8)-Cys-Pro-ArgGly-Gly-Ser-Val-Cys
(Wiley, 2009-08)This study is aimed at elucidating the structure of a novel T-cell adhesion inhibitor, cyclo(1,8)-CPRGGSVC using one- and two-dimensional 1H NMR and molecular dynamics (MD) simulation. The peptide is derived from the ... -
Recent trends in microdialysis sampling integrated with conventional and microanalytical systems for monitoring biological events: A review
(Elsevier, 2009-09-28)Microdialysis (MD) is a sampling technique that can be employed to monitor biological events both in vivo and in vitro. When it is coupled to an analytical system, microdialysis can provide near realtime information on the ... -
Effects of Dusulfide Bond Formation and Protein Helicity on the Aggregation of Activating Transcription Factor 5 (ATF5)
(American Chemical Society, 2009)Amorphous aggregation is a major problem for protein biopharmaceuticals, and aggregate formation in a drug formulation can have serious health implications for the patient. In many cases, an immunogenic response is generated ... -
cIBR effectively targets nanoparticles to LFA-1 on acute lymphoblastic T cells
(American Chemical Society, 2010-02-01)Leukocyte function associated antigen-1 (LFA-1) is a primary cell adhesion molecule of leukocytes required for mediating cellular transmigration into sites of inflammation via the vascular endothelium. A cyclic peptide, ... -
Cationic amphiphilic drugs cause a marked expansion of apparent lysosomal volume: Implications for an intracellular distribution-based drug interaction
(American Chemical Society, 2012-05-07)How a drug distributes within highly compartmentalized mammalian cells can affect both the activity and pharmacokinetic behavior. Many commercially available drugs are considered to be lysosomotropic, meaning they are ... -
Calcium-crosslinked LABL-TAT complexes effectively target gene delivery to ICAM-1 expressing cells
(American Chemical Society, 2011-06-06)Targeted gene delivery using non-viral vectors is a highly touted scheme to reduce the potential for toxic or immunological side effects by reducing dose. In previous reports, TAT polyplexes with DNA have shown relatively ... -
Biophysical and Stabilization Studies of the Chlamydia trachomatis Mouse Pneumonitis Major Outer Membrane Protein
(American Chemical Society, 2009)Native Chlamydia trachomatis mouse pneumonitis major outer membrane protein (nMOMP) induces effective protection against genital infection in a mouse challenge model. The conformation of nMOMP is crucial to confer this ... -
Intramolecular hydrogen transfer reactions of thiyl radicals from glutathione: formation of carbon-centered radical at Glu, Cys and Gly
(ACS, 2012-09-17)Glutathione thiyl radicals (GS•) were generated in H2O and D2O by either exposure of GSH to AAPH#, photoirradiation of GSH in the presence of acetone, or photoirradiation of GSSG. Detailed interpretation of the fragmentation ...