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    Hyaluronic acid graft polymers displaying peptide antigen madulate dendritic cell response in vitro

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    Sestak_2014.pdf (2.257Mb)
    Issue Date
    2014-01-06
    Author
    Chittasupho, Chuda
    Sestak, Joshua
    Shannon, Laura
    Siahaan, Teruna J.
    Vines, Charlotte M.
    Berkland, Cory J.
    Publisher
    American Chemical Society
    Type
    Article
    Article Version
    Scholarly/refereed, author accepted manuscript
    Rights
    This document is the Accepted Manuscript version of a Published Work that appeared in final form in Molecular Pharmaceutics, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://doi.org/10.1021/mp4003909.
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    Abstract
    A novel oxime grafting scheme was utilized to conjugate an ICAM-1 ligand (LABL), a cellular antigen ovalbumin (OVA), or both peptides simultaneously to hyaluronic acid (HA). Samples of HA only and the various peptide grafted HA were found to bind to dendritic cells (DCs). HA with grafted LABL and OVA showed the greatest binding to DCs. Dendritic cells treated with HA, HA with grafted LABL, or HA with grafted LABL and OVA, significantly suppressed T cell and DC conjugate formation, T cell proliferation and reduced proinflammatory cytokine production compared to untreated cells. These results suggest that HA serves as an effective backbone for multivalent ligand presentation for inhibiting T cell response to antigen presentation. In addition, multivalent display of both antigen and an ICAM-1inhibitor (LABL) may enhance binding to DCs and could potentially disrupt cellular signaling leading to autoimmunity.
    URI
    http://hdl.handle.net/1808/24051
    DOI
    https://doi.org/10.1021/mp4003909
    Collections
    • Pharmaceutical Chemistry Scholarly Works [353]
    Citation
    Chittasupho, C., Sestak, J., Shannon, L., Siahaan, T. J., Vines, C. M., & Berkland, C. (2014). Hyaluronic acid graft polymers displaying peptide antigen modulate dendritic cell response in vitro. Molecular Pharmaceutics, 11(1), 367–373. http://doi.org/10.1021/mp4003909

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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