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Molecular Biosciences: Recent submissions
Now showing items 761-780 of 887
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Restricted N-glycan Conformational Space in the PDB and Its Implication in Glycan Structure Modeling
(Public Library of Science, 2013-03-14)Understanding glycan structure and dynamics is central to understanding protein-carbohydrate recognition and its role in protein-protein interactions. Given the difficulties in obtaining the glycan's crystal structure in ... -
A Role for the Membrane in Regulating Chlamydomonas Flagellar Length
(Public Library of Science, 2013-01-24)Flagellar assembly requires coordination between the assembly of axonemal proteins and the assembly of the flagellar membrane and membrane proteins. Fully grown steady-state Chlamydomonas flagella release flagellar vesicles ... -
Mi2β Is Required for γ-Globin Gene Silencing: Temporal Assembly of a GATA-1-FOG-1-Mi2 Repressor Complex in β-YAC Transgenic Mice
(Public Library of Science, 2012-12-20)Activation of γ-globin gene expression in adults is known to be therapeutic for sickle cell disease. Thus, it follows that the converse, alleviation of repression, would be equally effective, since the net result would be ... -
THE ENTEROHEMORRHAGIC ESCHERICHIA COLI EFFECTOR PROTEIN NLEF BINDS MAMMALIAN HOST PROTEINS
(University of Kansas, 2012-12-31)The extracellular human pathogens enterohemorrhagic and enteropathogenic Escherichia coli (EHEC and EPEC) and the related mouse pathogen Citrobacter rodentium inject type III secretion system (T3SS) effector proteins to ... -
BIOGENESIS OF TELOMERASE RNA IN FISSION YEAST
(University of Kansas, 2012-08-31)Telomerase, a reverse transcriptase, counteracts the progressive loss of chromosome-terminal DNA sequences in most eukaryotes. Work from C. W. Greider and E. H. Blackburn first revealed telomerase activity in Tetrahymena ... -
The Tumor Suprressor APC: Nuclear Functions and Regulation by Heat Shock Response
(University of Kansas, 2012-05-31)Because mutation of the tumor suppressor APC initiates ~80% of all colorectal cancers, understanding APC function is central for better diagnostic, preventive, and therapeutic strategies for the disease. In-vitro studies ... -
Designing allosteric control into enzymes by chemical rescue of structure
(University of Kansas, 2012-12-31)In recent years chemical biology has been used to engineer ligand-dependent activity into enzymes to control a variety of signaling pathways, such as modulating protein production, degradation, and localization. These ... -
The role of the cadherin fmi-1/flamingo in the development of the D-type GABAergic neurons
(University of Kansas, 2012-12-31)Cadherin proteins are cell adhesion molecules involved in multiple aspects of the development of the nervous system. A subgroup of these proteins, called protocadherin, has been recently shown to play key roles during the ... -
Intercellular Adhesion Molecule-1 Guides Naive T Cell Differentiation and Regulatory T Cell Induction
(University of Kansas, 2012-12-31)The outcome of naïve T cell activation and differentiation is guided by cues received from the cellular microenvironment, including cytokine and costimulatory signals. Naïve T cell precursors can differentiate into a variety ... -
Structure and function of human cytochromes P450 enzymes: Xenobiotic metabolism by CYP2A and steroid biosynthesis by CYP17A1
(University of Kansas, 2011-05-31)Cytochrome P450 (CYP) is a superfamily of heme-containing enzymes that have roles in the breakdown or synthesis of steroids, fatty acids, vitamins, and eicosanoids. They are also the main family of enzymes involved in the ... -
VITAMIN D DEFICIENCY CAUSES MUSCULOSKELETAL HYPERSENSITIVITY: THE ROLE OF NOCICEPTOR HYPERINNERVATION
(University of Kansas, 2011-05-31)Clinical studies link vitamin D deficiency and musculoskeletal pain, both of which occur more frequently in women. However, a causal relationship has been difficult to establish and it is not clear whether vitamin D ... -
Protein structure prediction and structure-based protein function annotation
(University of Kansas, 2011-12-31)Nature tends to modify rather than invent function of protein molecules, and the log of the modifications is encrypted in the gene sequence. Analysis of these modification events in evolutionarily related genes is important ... -
STRUCTURAL MODELING OF PROTEIN-PROTEIN INTERACTIONS USING MULTIPLE-CHAIN THREADING AND FRAGMENT ASSEMBLY
(University of Kansas, 2011-12-31)Since its birth, the study of protein structures has made progress with leaps and bounds. However, owing to the expenses and difficulties involved, the number of protein structures has not been able to catch up with the ... -
THE DYNAMIC RELATIONSHIP BETWEEN LANGERHANS CELLS AND INTRAEPIDERMAL NERVE FIBERS IN THE MOUSE AND RAT FOOTPAD
(University of Kansas, 2011-12-31)Skin disorders are often associated with immune and nervous system dysfunction. Intraepidermal nerve fibers (IENFs) detect mechanical, thermal, and noxious stimuli. Although immune cells such as mast and T cells can alter ... -
The Escherichia coli RhaS Transcriptional Activator: Transcriptional Activation by the DNA-Binding Domain, The Interdomain Effector Response, and Negative Autoregulation
(University of Kansas, 2012-05-31)The chapters herein are the accepted manuscript versions of articles that were published independently in scholarly research journals. They have been combined and submitted in fulfillment of the thesis requirement for a ... -
The interaction of ICAM-1 with LFA-1: intercellular signaling and implication in type I diabetes
(University of Kansas, 2012-05-31)T lymphocytes are cells that play an essential role in both the regulation and activation of an immune response. The T cells role is two-fold: they migrate to an inflammatory site by interacting with endothelial cells ... -
CORTICO-MUSCLE ENCODING: EVOKING PRINCIPLES OF CORTICO-MUSCLE CONNECTIVITY WITH RL-ICMS
(University of Kansas, 2011-12-31)The specific aims of this study focus on three interrelated issues utilizing long-duration intracortical microstimulation (RL-ICMS) to elicit the organization and function of the rhesus macaque primary motor cortex (M1). ... -
Structural, Functional and Computational Characterization of Pseudomonas aeruginosa Siderophore Biosynthetic Pathway Accessory Proteins PchB and PvdA
(University of Kansas, 2012-05-31)To survive and establish infections in host tissues, pathogens must compete with the host organism for iron. One strategy for iron acquisition is to excrete iron-chelators, called siderophores, with very high affinity to ... -
MUTACIN IV PRODUCTION IN STREPTOCOCCUS MUTANS UA159: CHARACTERIZATION, REGULATION, AND MECHANISM OF SELF-IMMUNITY
(University of Kansas, 2012-05-31)Streptococcus mutans, an oral pathogen, is considered as a principle etiological agent of dental caries. To colonize successfully in the oral cavity, this organism encounters fierce competition with other oral microbiota ... -
Intercellular Adhesion Molecule-1 in T cell differentiation and as a target for peptide therapy of type 1 diabetes
(University of Kansas, 2012-05-31)CD4+ T cells are essential for proper function of the immune system. Many facets of an immune response are dependent on help from CD4+ T cells to become activated and exhibit effector function. Memory CD4+ T cells are a ...