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    VITAMIN D DEFICIENCY CAUSES MUSCULOSKELETAL HYPERSENSITIVITY: THE ROLE OF NOCICEPTOR HYPERINNERVATION

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    Tague_ku_0099D_11342_DATA_1.pdf (3.289Mb)
    Issue Date
    2011-05-31
    Author
    Tague, Sarah Elizabeth
    Publisher
    University of Kansas
    Format
    118 pages
    Type
    Dissertation
    Degree Level
    Ph.D.
    Discipline
    Molecular & Integrative Physiology
    Rights
    This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
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    Abstract
    Clinical studies link vitamin D deficiency and musculoskeletal pain, both of which occur more frequently in women. However, a causal relationship has been difficult to establish and it is not clear whether vitamin D metabolites directly influence nociceptors (`pain-sensing' neurons). It was shown here, via immunohistochemistry and western blot, that rat putative nociceptors contain vitamin D receptors (VDRs) and metabolic enzymes, whose expression is regulated by ovarian hormones. In ovariectomized rats a vitamin D deficient diet induces balance deficits and deep tissue mechanical hyperalgesia, concurrent with muscle hyperinnervation by presumed nociceptors. Balance deficits, muscle mechanical hypersensitivity, and hyperinnervation are not corrected by elevated dietary calcium. In primary sensory cultures, VDR is enriched in c-fiber growth cones and regulates neurite outgrowth through VDR rapid response pathways. Therefore, vitamin D metabolites act directly on nociceptive neurons to inhibit axonal sprouting, accounting for hypovitaminosis D-induced muscle hyperinnervation, and possibly contributing to hypersensitivity.
    URI
    http://hdl.handle.net/1808/10699
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    • Dissertations [4454]
    • Molecular Biosciences Dissertations and Theses [270]

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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