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Molecular Biosciences: Recent submissions
Now showing items 781-800 of 887
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Evolutionary divergence in proteins: experimental and theoretical studies on the stability and electrochemical properties of cytochrome b5
(University of Kansas, 2012-05-31)Cytochrome b5 (CYB5) is a small ubiquitous heme binding protein whose biochemical function is electron transfer. Two isoforms of CYB5 are found in mammals, which are named based on their specific subcellular localization. ... -
SUMOylation in cell death: SUMO E3 ligase PIAS1 plays a critical role in determining cell survival following UV stress
(University of Kansas, 2012-08-31)SUMO modification of proteins plays an important role in many cellular processes such as DNA replication, DNA repair, stress response, transcriptional regulation, signal transduction, cell cycle regulation, differentiation ... -
Quantitative Genetic Mapping of Life History Traits in Drosophila melanogaster
(University of Kansas, 2012-08-31)While it has long been established that populations of animals harbor substantial natural genetic variation for life history traits, an understanding of the location, effect, and frequency of naturally occurring alleles ... -
EXERCISE-INDUCED ORGAN PROTECTION IN A MURINE MODEL OF CARDIAC ARREST AND RESUSCITATION
(University of Kansas, 2012-08-31)Cardiac arrest causes whole-body ischemic injury and cell death. Successful cardiopulmonary resuscitation paradoxically confounds recovery by increasing the rate of cellular death and tissue damage through global reperfusion ... -
MODULATION OF THE NF-KAPPA B SIGNALING PATHWAY BY THE BACTERIAL TYPE III SECRETION SYSTEM EFFECTORS
(University of Kansas, 2012-08-31)The type III secretion system (T3SS) is a bacterial injection system expressed by many Gram-negative bacteria. During the last two decades, the repertoire of T3SS effectors has been greatly explored, and several mechanisms ... -
MIND-DEPENDENT CONFORMATIONAL CHANGES IN MINE REGULATE THE MIN OSCILLATION
(University of Kansas, 2012-05-31)The min system comprised of MinC, MinD, and MinE in Escherichia coli ensures that cell division occurs at the midcell position by preventing the assembly of FtsZ into a Z-ring at the poles. MinD is a member of the deviant ... -
PROBING THE LIPOPROTEIN SECRETION PATHWAY IN BORRELIA BURGDORFERI
(University of Kansas, 2012-05-31)The bacterial agent Borrelia burgdorferi causes Lyme disease, a debilitating inflammatory disease and a major public health issue in the United States and around the world. Early studies of B. burgdorferi pathogenesis ... -
ROLE OF AN ABC TRANSPORTER COMPLEX IN VIOLOGEN TOLERANCE IN STREPTOCOCCUS MUTANS
(University of Kansas, 2011-05-31)The gram-positive bacterium Streptococcus mutans is the primary causative agent in the formation of dental caries in humans. To persist in the oral cavity, S. mutans must be able to tolerate rapid and substantial environmental ... -
Genetic Contributions of desatF and eloF to Courtship Mating Behavior and Cuticular Hydrocarbon Production in Drosophila simulans and D. sechellia
(University of Kansas, 2011-12-31)Sexual isolation occurs between Drosophila simulans and D. sechellia due to differences in cuticular hydrocarbon (CHC) productions. A wide variety of hydrocarbons are produced, but D. simulans males and females predominantly ... -
Exploring Novel Properties of Adenomatous Polyposis Coli: Msi1-Knockout Mice Display Alterations in APC and Intestinal Cell Homeostasis; Topoisomerase IIa Binds to Truncated APC in Human Colon Cancer Cells
(University of Kansas, 2011-12-31)Abstract Colorectal cancer is the second leading cause of cancer-related death in the United States. Adenomatous polyposis coli (APC) is the initiating mutation in 80% of all colorectal cancers. Our lab is focused on ... -
The Influence of Hydrophobic Mismatch on Structure and Dynamics of Transmembrane Helices and Lipid Bilayers
(University of Kansas, 2011-12-31)Membrane proteins with one or a few transmembrane (TM) helices are abundant and often involved in important TM-included signaling and regulation through formation of hetero- and homo-oligomers. Especially, solid-state NMR ... -
Schistosoma Mansonii aspartic protease expression and refolding trials
(University of Kansas, 2011-12-31)Schistosomiasis is a parasitic disease that causes considerable socio-economic losses in affected areas due to loss of productive capacity of affected individuals and high rates of morbidity and mortality. Therapeutic ... -
Conformational Entropy in PEPCK Catalysis: Dynamic Motions Critical to Function
(University of Kansas, 2011-12-31)Enzymes increase the rate at which chemical reactions occur. How they achieve this rate increase has been an area of intense research for many years. Multiple studies have shown that dynamic motions of individual protein ... -
CHARACTERIZATION OF MATRIMONY'S ROLE AS A POLO KINASE REGULATOR DURING DROSOPHILA FEMALE MEIOSIS
(University of Kansas, 2011-12-31)Regulatory interactions that occur between Polo-like kinase 1 (Plk1) and its protein partners are critical for promoting many different cell division events. Indeed, Plk1 is found mis-regulated in a diverse set of human ... -
THE ROLE OF ADAPTOR PROTEIN GADS IN CD8+ T CELL-MEDIATED IMMUNITY
(University of Kansas, 2011-12-31)CD8+ T cells are the branch of the adaptive immune system responsible for recognizing and killing tumor cells or cells infected with intracellular pathogens, such as Listeria monocytogenes (LM). However, when CD8+ T cells ... -
Nigrostriatal Dopmaine Function and Insulin Resistance
(University of Kansas, 2011-08-31)Clinical studies have linked Type 2 Diabetes (T2D) with neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease (PD). Although the link between T2D and AD is relatively well established, the potential ... -
THE NA,K-ATPASE α4 ISOFORM: MECHANISMS OF ACTION, REGULATION AND RELEVANCE TO MALE FERTILITY
(University of Kansas, 2011-08-31)Ion movement across the plasma membrane is essential for the function of spermatozoa and defects in the mechanisms that drive ion transport between the environment and cell cytoplasm can affect male fertility. The active ... -
Some Studies in the Agglutination of Typhoid
(University of Kansas, 1911-05-15) -
Multiple Distinct Roles for the Rab11 GTPase in the Somatic Cells of the Drosophila Egg Chamber
(University of Kansas, 2011-05-31)The Drosophila egg chamber provides an excellent system in which to study the specification and differentiation of epithelial cell fates because all of the steps, starting with the division of the corresponding stem cells ... -
Modulation of Tau Dysfunction In Vitro
(University of Kansas, 2011-05-31)The microtubule associated protein tau is a causative factor in a class of neurodegenerative diseases termed tauopathies. Alzheimer's disease (AD) is the most prevalent tauopathy. In AD, natively unfolded, tau becomes ...