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Molecular Biosciences: Recent submissions
Now showing items 741-760 of 887
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Autism genetic database (AGD): a comprehensive database including autism susceptibility gene-CNVs integrated with known noncoding RNAs and fragile sites
(BioMed Central, 2009-09-24)Background: Autism is a highly heritable complex neurodevelopmental disorder, therefore identifying its genetic basis has been challenging. To date, numerous susceptibility genes and chromosomal abnormalities have been ... -
FLI-1 Flightless-1 and LET-60 Ras control germ line morphogenesis in C. elegans
(BioMed Central, 2008-05-16)Background: In the C. elegans germ line, syncytial germ line nuclei are arranged at the cortex of the germ line as they exit mitosis and enter meiosis, forming a nucleus-free core of germ line cytoplasm called the rachis. ... -
DECK: Distance and environment-dependent, coarse-grained, knowledge-based potentials for protein-protein docking
(BioMed Central, 2011-07-11)Background: Computational approaches to protein-protein docking typically include scoring aimed at improving the rank of the near-native structure relative to the false-positive matches. Knowledge-based potentials improve ... -
A novel bocavirus in canine liver
(BioMed Central, 2013-02-13)Background: Bocaviruses are classified as a genus within the Parvoviridae family of single-stranded DNA viruses and are pathogenic in some mammalian species. Two species have been previously reported in dogs, minute virus ... -
Caenorhabditis elegans voltage-gated calcium channel subunits UNC-2 and UNC-36 and the calcium-dependent kinase UNC-43/CaMKII regulate neuromuscular junction morphology
(BioMed Central, 2013-01-01)The conserved Caenorhabditis elegans proteins NID-1/nidogen and PTP-3A/LAR-RPTP function to efficiently localize the presynaptic scaffold protein SYD-2/α-liprin at active zones. Loss of function in these molecules results ... -
Revisiting the Plasmodium falciparum RIFIN family: from comparative genomics to 3D-model prediction.
(BioMed Central, 2009-09-21)Subtelomeric RIFIN genes constitute the most abundant multigene family in Plasmodium falciparum. RIFIN products are targets for the human immune response and contribute to the antigenic variability of the parasite. They ... -
Omalizumab may decrease IgE synthesis by targeting membrane IgE+ human B cells
(BioMed Central, 2013-09-02)Omalizumab, is a humanized anti-IgE monoclonal antibody used to treat allergic asthma. Decreased serum IgE levels, lower eosinophil and B cell counts have been noted as a result of treatment. In vitro studies and animal ... -
A Family of GFP-like Proteins with Different Spectral Properties in Lancelet Branchiostoma Floridae
(Springer, 2008-07-03)Background: Members of the green fluorescent protein (GFP) family share sequence similarity and the 11-stranded β-barrel fold. Fluorescence or bright coloration, observed in many members of this family, is enabled by the ... -
Rheostats and Toggle Switches for Modulating Protein Function
(Public Library of Science, 2013-12-30)The millions of protein sequences generated by genomics are expected to transform protein engineering and personalized medicine. To achieve these goals, tools for predicting outcomes of amino acid changes must be improved. ... -
Machines vs. Ensembles: Effective MAPK Signaling through Heterogeneous Sets of Protein Complexes
(Public Library of Science, 2013-10-10)Despite the importance of intracellular signaling networks, there is currently no consensus regarding the fundamental nature of the protein complexes such networks employ. One prominent view involves stable signaling ... -
STRUCTURAL AND FUNCTIONAL STUDIES OF THREE PROTEINS OF UNKNOWN FUNCTION ENCODED BY CHLAMYDIA TRACHOMATIS
(University of Kansas, 2013-05-31)Infections by chlamydial species are of significant impact to global public health, causing sexually transmitted infections, blinding trachoma and pneumonia. Despite its importance, there are many aspects of chlamydial ... -
Modifications of the tau protein and their varied effects on aggregation and function
(University of Kansas, 2013-05-31)Tau is a microtubule-associated protein that is typically found in the axons of neurons. Six isoforms of the protein can be generated through alternative mRNA splicing and all are found in the adult brain. The protein is ... -
Novel Direct Targets and Functional Roles for MicroRNA-21 in Granulosa Cells and Human Uterine Leiomyomas
(University of Kansas, 2013-08-31)MicroRNA-21 (miR-21) is important for maintaining optimal ovulation rates and granulosa cell viability. It is also upregulated in human uterine leiomyomas (ULMs), a disease characterized by the presence of benign tumors ... -
Regulation Of Fshr And SF-1 In The Hypothalamus-Pituitary-Gonadal (HPG) Axis.
(University of Kansas, 2013-08-31)Mammalian reproduction is highly dependent on the delicate balance of signals within the hypothalamic-pituitary-gonadal (HPG) axis that maintains proper endocrine environment. One of the key signals is the pituitary ... -
Characterization of three novel RNAi machinery components in C. elegans
(University of Kansas, 2013-08-31)RNA interference (RNAi) is a homology-based and antisense small RNA-dependent gene silencing mechanism found in most eukaryotes. This dissertation describes identification and characterization of three novel RNAi pathway ... -
Influence of the host cell factors CK2, hTERT, and PML, on the antiviral response to herpes simplex virus type I infection
(University of Kansas, 2013-08-31)Herpes simplex virus type I (HSV-1) is a significant human pathogen that infects a large portion of the human population. As an obligate intracellular parasite, HSV-1 requires certain cellular factors for its replication; ... -
Cloning and characterization of EXC-1, an IRGP homologue that controls Intracellular Trafficking and the Maintenance of Shape in Small Biological Tubes
(University of Kansas, 2013-08-31)Biological tubes are ubiquitous structures that carry out vital roles. The formation and maintenance of these tubule structures is a fundamental process in most organisms. The goal of this work is to get a better understanding ... -
On the development of a GroEL based platform for identifying pharmacological chaperones
(University of Kansas, 2013-05-31)Many protein misfolding diseases are due to changes in protein homeostasis. This might lead to protein misfolding and possibly intra- or extracellular aggregation, causing loss of protein function or gain of toxic function. ... -
THE APPLICATION OF HISTONE ANALYSIS FOR IDENTIFYING DISTAL REGULATORY ELEMENTS - REGULATION OF FSHR
(University of Kansas, 2013-05-31)Mechanisms that regulate gene expression are fundamental to many complex biological processes and disease states. Genome-wide approaches that combine chromatin-immunoprecipitation (ChIP) and next-generation sequencing have ... -
Functional analysis of actin-like protein MreB and alternative sigma factor RpoN in chlamydial developmental cycle
(University of Kansas, 2013-05-31)Chlamydia trachomatis is an obligate intracellular pathogen of immense public health impact and is responsible for diverse disease states leading to blindness, sterility, atherosclerosis etc. in humans. Its unique biphasic ...