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    Bcl2:Beclin 1 complex: multiple mechanisms regulating autophagy/apoptosis toggle switch

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    XuLiang_AJCR_2(2)214.pdf (669.6Kb)
    Issue Date
    2012-02-28
    Author
    Marquez, Rebecca T.
    Xu, Liang
    Publisher
    e-Century Publishing
    Type
    Article
    Article Version
    Scholarly/refereed, publisher version
    Published Version
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3304572/
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    Abstract
    Cancer cells have developed novel mechanisms for evading chemotherapy-induced apoptosis and autophagy-associated cell death pathways. Upon the discovery that chemotherapeutics could target these cell death pathways in a manner that was not mutually exclusive, new discoveries about the interrelationship between these two pathways are emerging. Key proteins originally thought to be “autophagy-related proteins” are now found to be involved in either inducing or inhibiting apoptosis. Similarly, apoptosis inhibiting proteins can also block autophagy-associated cell death. One example is the complex formed by the autophagy protein, Beclin 1, and anti-apoptotic protein Bcl-2, which leads to inhibition of autophagy-associated cell death. Researchers have been investigating additional mechanisms that form/disrupt this complex in order to better design chemotherapeutics. This review will highlight the role Bcl-2 and Beclin 1 play in cancer development and drug resistance, as well as the role the Bcl-2:Beclin 1 complex in the switch between autophagy and apoptosis.
    Description
    This is the published version, also available here: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3304572/.
    URI
    http://hdl.handle.net/1808/17365
    Collections
    • Molecular Biosciences Scholarly Works [590]
    Citation
    Marquez, Rebecca T. & Xu, Liang. "Bcl2:Beclin 1 complex: multiple mechanisms regulating autophagy/apoptosis toggle switch." (2011) Am J Cancer Res. 2012; 2(2): 214–221.

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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