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    Drosophila coracle, a Member of the Protein 4.1 Superfamily, Has Essential Structural Functions in the Septate Junctions and Developmental Functions in Embryonic and Adult Epithelial Cells

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    Issue Date
    1998-09-15
    Author
    Lamb, Rebecca S.
    Schweizer, Liang
    Fehon, Richard G.
    Ward, Robert E., IV
    Publisher
    American Society for Cell Biology
    Type
    Article
    Article Version
    Scholarly/refereed, publisher version
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    Abstract
    Although extensively studied biochemically, members of the Protein 4.1 superfamily have not been as well characterized genetically. Studies of coracle, a DrosophilaProtein 4.1 homologue, provide an opportunity to examine the genetic functions of this gene family. coracle was originally identified as a dominant suppressor ofEgfr Elp, a hypermorphic form of theDrosophila Epidermal growth factor receptor gene. In this article, we present a phenotypic analysis ofcoracle, one of the first for a member of the Protein 4.1 superfamily. Screens for new coracle alleles confirm the null coracle phenotype of embryonic lethality and failure in dorsal closure, and they identify additional defects in the embryonic epidermis and salivary glands. Hypomorphiccoracle alleles reveal functions in many imaginal tissues. Analysis of coracle mutant cells indicates that Coracle is a necessary structural component of the septate junction required for the maintenance of the transepithelial barrier but is not necessary for apical–basal polarity, epithelial integrity, or cytoskeletal integrity. In addition, coracle phenotypes suggest a specific role in cell signaling events. Finally, complementation analysis provides information regarding the functional organization of Coracle and possibly other Protein 4.1 superfamily members. These studies provide insights into a range of in vivo functions for coracle in developing embryos and adults.
    Description
    This is the published version, also available here: http://dx.doi.org/10.1091/mbc.9.12.3505.
    URI
    http://hdl.handle.net/1808/17366
    DOI
    https://doi.org/10.1091/mbc.9.12.3505
    Collections
    • Molecular Biosciences Scholarly Works [598]
    Citation
    Lamb, Rebecca S., Ward, Robert E., Schwizer, Liang., Fehon, Richard G. "Drosophila coracle, a Member of the Protein 4.1 Superfamily, has Essential Structural Functions in the Septate Junctions and Developmental Functions in Embryonic and Adult Epithelial Cells." Mol. Biol. Cell December 1, 1998 vol. 9 no. 12 3505-3519. http://dx.doi.org/10.1091/mbc.9.12.3505.

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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