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Molecular Biosciences: Recent submissions
Now showing items 501-520 of 887
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Crystallization and Preliminary X-Ray Analysis of Human Muscle Creatine Kinase
(International Union of Crystallography, 1999-03-01)Creatine kinase is a key enzyme in the energy homeostasis of cells and tissues with high and fluctuating energy demands. Human muscle MM creatine kinase is a dimeric protein with a molecular weight of \sim43 kDa for each ... -
Structure of [N,N'-propylenebis(2-pyrrolylmethyleneaminato)]nickel(II)
(Acta Crystallographica C, 1989-01-01)See article for abstract. -
Structure of C22H36N10O2S2
(International Union of Crystallography, 1988-01-01)See article for abstract. -
Structure of (1S*,5S*,SR*)-1-(3-p-toluenesulfinyl-2-propenyl)-2-methylene-7,7-dimethylbicyclo[3.3.0]octan-3-one
(International Union of Crystallography, 1987-01-01)See article for abstract. -
Structures of two isomeric phenylethanolamine analogs containing the benzobicyclo[3.2.1]octane skeleton
(International Union of Crystallography, 1987-01-01)See article for abstract. -
Structure of N-[1'(9-adenyl)-[beta]-D-ribofuranuronosyl]-L-phenylalanine water ethanol (1/0.5/0.25), C19H20N6O6.0.5H2O.0.25C2H6O
(International Union of Crystallography, 1985-01-01)See article for abstract. -
Neutron diffraction study at 37 K of sodium triaqua(ethylenediaminetetraacetato)samarate(III) pentahydrate, Na[Sm(C10H12N2O8)(H2O)3].5H2O
(International Union of Crystallography, 1984-01-01)See article for abstract. -
Adaptable functionality of transcriptional feedback in bacterial two-component systems
(Public Library of Science, 2010-02-12)A widespread mechanism of bacterial signaling occurs through two-component systems, comprised of a sensor histidine kinase (SHK) and a transcriptional response regulator (RR). The SHK activates RR by phosphorylation. The ... -
Interplay of gene expression noise and ultrasensitive dynamics affects bacterial operon organization
(Public Library of Science, 2012-08-30)Bacterial chromosomes are organized into polycistronic cotranscribed operons, but the evolutionary pressures maintaining them are unclear. We hypothesized that operons alter gene expression noise characteristics, resulting ... -
Adaptive evolution of the lactose utilization network in experimentally evolved populations of Escherichia coli
(Public Library of Science, 2012-01-12)Adaptation to novel environments is often associated with changes in gene regulation. Nevertheless, few studies have been able both to identify the genetic basis of changes in regulation and to demonstrate why these changes ... -
The role of protein kinase C in thromboxane A<sub>2</sub> - induced pulmonary artery vasoconstriciton
(BioMed Central, 1999-07-01)In order to determine if protein kinase C (PKC) plays a significant role in the stimulant action of thromboxane A2 (TxA2) on pulmonary vascular smooth muscle, TxA2-induced contractile responses were measured following ... -
Timely septation requires SNAD-dependent spindle pole body localization of the septation initiation network components in the filamentous fungus Aspergillus nidulans
(American Society for Cell Biology, 2009-06-15)In the filamentous fungus Aspergillus nidulans, cytokinesis/septation is triggered by the septation initiation network (SIN), which first appears at the spindle pole body (SPB) during mitosis. The coiled-coil protein SNAD ... -
Isolation of mip (microtubule interacting protein) mutations of Aspergillus nidulans
(American Society for Microbiology, 1986-08-01)We identified four mutations in two previously undescribed loci involved in microtubule function in Aspergillus nidulans as extragenic suppressors of benA33, a heat-sensitive beta-tubulin mutation. Three of the four mutations ... -
Mlp1 acts as a scaffold to localize Mad1 in between reforming telophase nuclei in Aspergillus nidulans
(American Society for Cell Biology, 2009-04-15)During open mitosis several nuclear pore complex (NPC) proteins have mitotic specific localizations and functions. We find that the Aspergillus nidulans Mlp1 NPC protein has previously unrealized mitotic roles involving ... -
The tip growth apparatus of Aspergillus nidulans
(American Society for Cell Biology, 2008-04-01)Hyphal tip growth in fungi is important because of the economic and medical importance of fungi, and because it may be a useful model for polarized growth in other organisms. We have investigated the central questions of ... -
The role of microtubules in rapid hyphal tip growth of Aspergillus nidulans
(American Society for Cell Biology, 2005-02-01)The filamentous fungus Aspergillus nidulans grows by polarized extension of hyphal tips. The actin cytoskeleton is essential for polarized growth, but the role of microtubules has been controversial. To define the role of ... -
Neutron diffraction study of lithium hydrogen phthalate monohydrate: A material with two very short intramolecular O⋅⋅⋅H⋅⋅⋅O hydrogen bonds
(American Institute of Physics, 1985)The structure of lithium hydrogen phthalate monohydrate has been refined based upon neutron diffraction data obtained at three temperatures: 15, 100, and 298 K. All bond distances have been determined with precision better ... -
Cytoplasmic dynein’s mitotic spindle pole localization requires a functional anaphase-promoting complex, γ-tubulin, and NUDF/LIS1 in Aspergillus nidulans
(American Society for Cell Biology, 2005-08-01)In Aspergillus nidulans, cytoplasmic dynein and NUDF/LIS1 are found at the spindle poles during mitosis, but they seem to be targeted to this location via different mechanisms. The spindle pole localization of cytoplasmic ... -
Structure of Escherichia coli malate dehydrogenase at 1.45 Å resolution
(International Union of Crystallography, 2009-09)The structure of apo malate dehydrogenase from Escherichia coli has been determined to 1.45 Å resolution. The crystals belonged to space group C2, with unit-cell parameters a = 146.0, b = 52.0, c = 168.9 Å, [beta] = 102.2°. ... -
Purification, crystallization and preliminary X-ray diffraction studies of retinal dehydrogenase type II
(International Union of Crystallography, 1998-07)One enzyme which catalyzes the last step of the formation of the hormone retinoic acid from vitamin A (retinol) is retinal dehydrogenase type II (RalDH2). RalDH2, expressed in the Escherichia coli BL21(DE3) strain, was ...