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    The tip growth apparatus of Aspergillus nidulans

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    Oakley_MBC_19(4)1439.pdf (690.2Kb)
    Issue Date
    2008-04-01
    Author
    Taheri-Talesh, Naimeh
    Horio, Tetsuya
    Araujo-Bazan, Lidia
    Dou, Xiaowei
    Espeso, Eduardo A.
    Penalva, Miguel A.
    Osmani, Stephen A.
    Publisher
    American Society for Cell Biology
    Type
    Article
    Article Version
    Scholarly/refereed, publisher version
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    Abstract
    Hyphal tip growth in fungi is important because of the economic and medical importance of fungi, and because it may be a useful model for polarized growth in other organisms. We have investigated the central questions of the roles of cytoskeletal elements and of the precise sites of exocytosis and endocytosis at the growing hyphal tip by using the model fungus Aspergillus nidulans. Time-lapse imaging of fluorescent fusion proteins reveals a remarkably dynamic, but highly structured, tip growth apparatus. Live imaging of SYNA, a synaptobrevin homologue, and SECC, an exocyst component, reveals that vesicles accumulate in the Spitzenkörper (apical body) and fuse with the plasma membrane at the extreme apex of the hypha. SYNA is recycled from the plasma membrane by endocytosis at a collar of endocytic patches, 1–2 μm behind the apex of the hypha, that moves forward as the tip grows. Exocytosis and endocytosis are thus spatially coupled. Inhibitor studies, in combination with observations of fluorescent fusion proteins, reveal that actin functions in exocytosis and endocytosis at the tip and in holding the tip growth apparatus together. Microtubules are important for delivering vesicles to the tip area and for holding the tip growth apparatus in position.
    Description
    This is the publisher's version, also available electronically from "http://www.molbiolcell.org".
    URI
    http://hdl.handle.net/1808/17555
    DOI
    https://doi.org/10.1091/mbc.E07-05-0464
    Collections
    • Molecular Biosciences Scholarly Works [581]
    Citation
    Taheri-Talesh, N., Horio, T., Araujo-Bazan, L., Dou, X., Espeso, E., Penalva, M., . . . Oakley, B. (2008). The Tip Growth Apparatus of Aspergillus nidulans. Molecular Biology of the Cell, 19(4), 1439-1449. http://www.dx.doi.org/10.1091/mbc.E07-05-0464

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    KU Libraries
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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