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Molecular Biosciences: Recent submissions
Now showing items 141-160 of 887
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Structural variants exhibit widespread allelic heterogeneity and shape variation in complex traits
(Nature Research, 2019-10-25)It has been hypothesized that individually-rare hidden structural variants (SVs) could account for a significant fraction of variation in complex traits. Here we identified more than 20,000 euchromatic SVs from 14 Drosophila ... -
Designing Small Molecule Inhibitors of RNA-Binding Protein Musashi Using New Biochemical and Computational Approaches
(University of Kansas, 2019-12-31)ABSTRACT RNA-binding proteins (RBPs) are key regulators of post-transcriptional gene expression, and underlie many disease-relevant processes. However, they have historically been challenging to target with drug-like ... -
Activation and Inhibition of Biological Function through Design of Novel Protein-Ligand Interactions
(University of Kansas, 2019-05-31)Virtually every process within a cell involves a protein. They serve as cellular workhorses carrying out functions such as catalysis of essential metabolites, to regulating which genes get turned on or off, to forming the ... -
Mechanistic Insights into Specific G Protein Interactions with Adenosine Receptors
(American Chemical Society, 2019-07-08)Coupling between G-protein-coupled receptors (GPCRs) and the G proteins is a key step in cellular signaling. Despite extensive experimental and computational studies, the mechanism of specific GPCR–G protein coupling remains ... -
G‐Protein‐Coupled Receptor–Membrane Interactions Depend on the Receptor Activation State
(Wiley, 2019-10-10)G‐protein‐coupled receptors (GPCRs) are the largest family of human membrane proteins and serve as primary targets of approximately one‐third of currently marketed drugs. In particular, adenosine A1 receptor (A1AR) is an ... -
Recent advances in computational studies of GPCR-G protein interactions
(Elsevier, 2019-01-03)Protein-protein interactions are key in cellular signaling. G protein-coupled receptors (GPCRs), the largest superfamily of human membrane proteins, are able to transduce extracellular signals (e.g., hormones and ... -
Enteric infection coupled with chronic Notch pathway inhibition alters colonic mucus composition leading to dysbiosis, barrier disruption and colitis
(Public Library of Science, 2018-11-01)Intestinal mucus layer disruption and gut microflora modification in conjunction with tight junction (TJ) changes can increase colonic permeability that allows bacterial dissemination and intestinal and systemic disease. ... -
Predicting the Most Tractable Protein Surfaces in the Human Proteome for Developing New Therapeutics
(University of Kansas, 2019-05-31)A critical step in the target identification phase of drug discovery is evaluating druggability, i.e., whether a protein can be targeted with high affinity using drug-like ligands. The overarching goal of my PhD thesis is ... -
Using Chemical Biology to Modulate Antibody Activity
(University of Kansas, 2019-05-31)Monoclonal antibodies have shown promising results as therapeutic agents, and yet they can also be associated with adverse side effects due to activity outside the disease site. Aiming to reduce these side effects, we have ... -
A Conserved Cytoskeletal Signaling Cascade Mediates Neurotoxicity of FTDP-17 Tau Mutations In Vivo
(Society for Neuroscience, 2018-01-03)The microtubule binding proteintau is strongly implicated in multiple neurodegenerative disorders, includingfrontotemporal dementia and parkinsonism linkedto chromosome 17 (FTDP-17), which is caused by mutations intau.In ... -
Comparative Characterization of Crofelemer Samples Using Data Mining and Machine Learning Approaches With Analytical Stability Data Sets
(Elsevier, 2017-11-01)There is growing interest in generating physicochemical and biological analytical data sets to compare complex mixture drugs, for example, products from different manufacturers. In this work, we compare various crofelemer ... -
Inhibition of protein interactions: co-crystalized protein–protein interfaces are nearly as good as holo proteins in rigid-body ligand docking
(Springer International Publishing, 2018-07-12)Modulating protein interaction pathways may lead to the cure of many diseases. Known protein–protein inhibitors bind to large pockets on the protein–protein interface. Such large pockets are detected also in the protein–protein ... -
Transposon Mutagenesis in Chlamydia trachomatis Identifies CT339 as a ComEC Homolog Important for DNA Uptake and Lateral Gene Transfer
(American Society for Microbiology, 2019-08-06)Transposon mutagenesis is a widely applied and powerful genetic tool for the discovery of genes associated with selected phenotypes. Chlamydia trachomatis is a clinically significant, obligate intracellular bacterium for ... -
Efflux Pumps Represent Possible Evolutionary Convergence onto the Beta Barrel Fold
(bioRxiv, 2018-02-19)There are around 100 types of integral outer membrane proteins in each Gram negative bacteria. All of these proteins have the same fold—an up-down β-barrel. It has been suggested that all membrane β-barrels other than ... -
Cell cycle functions of gamma-tubulin, cyclins, and E3 ubiquitin ligases in Aspergillus nidulans
(University of Kansas, 2018-07-31)In addition to its well-established role in nucleating microtubules at microtubule-organizing centers, γ-tubulin has essential, microtubule-independent functions that are incompletely understood [reviewed in (Oakley et ... -
NEW INSIGHTS INTO THE ROLE OF UNC-6/NETRIN IN GROWTH CONE PROTRUSION, POLARITY AND CYTOSKELETAL ORGANIZATION
(University of Kansas, 2018-08-31)The formation of complex neuronal circuits is crucial for the proper development of the central nervous system. The wiring structure of the nervous system underlies its function in sensation and movement, and higher order ... -
Text Mining for Protein-Protein Docking
(University of Kansas, 2018-08-31)Scientific publications are a rich but underutilized source of structural and functional information on proteins and protein interactions. Although scientific literature is intended for human audience, text mining makes ... -
Current state of tau aggregation inhibitors
(University of Kansas, 2018-05-31)Tau is an intrinsically disordered, heat stable, and highly soluble protein found primarily in the axons of the central nervous system. It belongs to the family of structural microtubule-associated proteins, the major ... -
A Step Closer to Precision Oncology: Computational, Biochemical, and Cell-Based Screening to Find Compounds that Stabilize p53
(University of Kansas, 2018-05-31)Personalized medicine in cancer aims to tailor a treatment plan that takes into account the unique features of a patient's malignancy. One therapeutic target that has a chance to affect a large population of cancer patients ... -
Quorum sensing-controlled genes increase the survival of Chromobacterium violaceum during bacterial interspecies competition
(University of Kansas, 2018-05-31)Many Proteobacteria use a cell-cell communication system called quorum sensing (QS) to coordinate gene expression in a cell density-dependent manner. Cell density is detected through the production and diffusion of ...