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Molecular Biosciences: Recent submissions
Now showing items 121-140 of 887
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A further study of the antigenic properties of Euglena gracilis, Klebs, with related phenomena
(University of Kansas, 1933-05-31) -
Serological studies of the Reptilia
(University of Kansas, 1938-05-31) -
The Pheromone Module SteC-MkkB-MpkB-SteD-HamE Regulates Development, Stress Responses and Secondary Metabolism in Aspergillus fumigatus
(Frontiers Media, 2020-05-07)In order for eukaryotes to efficiently detect and respond to environmental stimuli, a myriad of protein signaling pathways are utilized. An example of highly conserved signaling pathways in eukaryotes are the mitogen-activated ... -
The Viral Macrodomain Counters Host Antiviral ADP-Ribosylation
(MDPI, 2020-03-31)Macrodomains, enzymes that remove ADP-ribose from proteins, are encoded by several families of RNA viruses and have recently been shown to counter innate immune responses to virus infection. ADP-ribose is covalently attached ... -
Dissecting the Genetic Basis of Variation in Drosophila Sleep Using a Multiparental QTL Mapping Resource
(MDPI, 2020-03-11)There is considerable variation in sleep duration, timing and quality in human populations, and sleep dysregulation has been implicated as a risk factor for a range of health problems. Human sleep traits are known to be ... -
Functional Characterization of Clinical Isolates of the Opportunistic Fungal Pathogen Aspergillus nidulans
(American Society for Microbiology, 2020-04-08)Aspergillus nidulans is an opportunistic fungal pathogen in patients with immunodeficiency, and virulence of A. nidulans isolates has mainly been studied in the context of chronic granulomatous disease (CGD), with ... -
The Hox Gene egl-5 Acts as a Terminal Selector for VD13 Development via Wnt Signaling
(MDPI, 2020-03-03)Nervous systems are comprised of diverse cell types that differ functionally and morphologically. During development, extrinsic signals, e.g., growth factors, can activate intrinsic programs, usually orchestrated by networks ... -
Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis
(Nature Research, 2020-04-24)Patients diagnosed with metastatic breast cancer have a dismal 5-year survival rate of only 24%. The RNA-binding protein Hu antigen R (HuR) is upregulated in breast cancer, and elevated cytoplasmic HuR correlates with ... -
A naturally-occurring 22-bp coding deletion in Ugt86Dd reduces nicotine resistance in Drosophila melanogaster
(BMC, 2020-03-30)Objective Segregating genetic variants contribute to the response to toxic, xenobiotic compounds, and identifying these causative sites can help describe the mechanisms underlying metabolism of toxic compounds. In previous ... -
Crystal and solution structures of human oncoprotein Musashi‐2 N‐terminal RNA recognition motif 1
(Wiley, 2019-10-29)Musashi‐2 (MSI2) belongs to Musashi family of RNA binding proteins (RBP). Like Musashi‐1 (MSI1), it is overexpressed in a variety of cancers and is a promising therapeutic target. Both MSI proteins contain two N‐terminal ... -
The Genetic Basis of Natural Variation in Drosophila melanogaster Immune Defense against Enterococcus faecalis
(MDPI, 2020-02-22)Dissecting the genetic basis of natural variation in disease response in hosts provides insights into the coevolutionary dynamics of host-pathogen interactions. Here, a genome-wide association study of Drosophila melanogaster ... -
The impact of PARPs and ADP-ribosylation on inflammation and host–pathogen interactions
(Cold Spring Harbor Laboratory Press, 2020-03-01)Poly-adenosine diphosphate-ribose polymerases (PARPs) promote ADP-ribosylation, a highly conserved, fundamental posttranslational modification (PTM). PARP catalytic domains transfer the ADP-ribose moiety from NAD+ to amino ... -
APC controls Wnt-induced β-catenin destruction complex recruitment in human colonocytes
(MDPI, 2020-02-19)Wnt/β-catenin signaling is essential for intestinal homeostasis and is aberrantly activated in most colorectal cancers (CRC) through mutation of the tumor suppressor Adenomatous Polyposis Coli (APC). APC is an essential ... -
The C. elegans CHP1 homolog, pbo-1, functions in innate immunity by regulating the pH of the intestinal lumen
(Public Library of Science, 2020-01-09)Caenorhabditis elegans are soil-dwelling nematodes and models for understanding innate immunity and infection. Previously, we developed a novel fluorescent dye (KR35) that accumulates in the intestine of C. elegans and ... -
A Deep Learning Approach for Detecting Copy Number Variation in Next-Generation Sequencing Data
(Genetics Society of America, 2019-08-27)Copy number variants (CNV) are associated with phenotypic variation in several species. However, properly detecting changes in copy numbers of sequences remains a difficult problem, especially in lower quality or lower ... -
Improved Modeling of Peptide-Protein Binding Through Global Docking and Accelerated Molecular Dynamics Simulations
(Frontiers Media, 2019-10-30)Peptides mediate up to 40% of known protein-protein interactions in higher eukaryotes and play a key role in cellular signaling, protein trafficking, immunology, and oncology. However, it is challenging to predict ... -
Dynamic Evolution of Antimicrobial Peptides Underscores Trade-Offs Between Immunity and Ecological Fitness
(Frontiers Media, 2019-11-08)There is a developing interest in how immune genes may function in other physiological roles, and how traditionally non-immune peptides may, in fact, be active in immune contexts. In the absence of infection, the induction ... -
Diversity in lac Operon Regulation among Diverse Escherichia coli Isolates Depends on the Broader Genetic Background but Is Not Explained by Genetic Relatedness
(American Society for Microbiology, 2019-11-12)Transcription of bacterial genes is controlled by the coordinated action of cis- and trans-acting regulators. The activity and mode of action of these regulators can reflect different requirements for gene products in ... -
Balancing Selection Drives the Maintenance of Genetic Variation in Drosophila Antimicrobial Peptides
(Oxford University Press, 2019-09-04)Genes involved in immune defense against pathogens provide some of the most well-known examples of both directional and balancing selection. Antimicrobial peptides (AMPs) are innate immune effector genes, playing a key ... -
An assessment of the immune costs associated with meiotic drive elements in Drosophila
(The Royal Society, 2019-09-18)Most organisms are constantly adapting to pathogens and parasites that exploit their host for their own benefit. Less studied, but perhaps more ubiquitous, are intragenomic parasites or selfish genetic elements. These ...