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    Efflux Pumps Represent Possible Evolutionary Convergence onto the Beta Barrel Fold

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    Slusky_et_al_2018_EffluxPumps.pdf (2.308Mb)
    Issue Date
    2018-02-19
    Author
    Franklin, Meghan Whitney
    Nepomnyachiy, Sergey
    Feehan, Ryan
    Ben-Tal, Nir
    Kolodny, Rachel
    Slusky, Joanna S.G.
    Publisher
    bioRxiv
    Type
    Preprint
    Rights
    Copyright 2018, The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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    Abstract
    There are around 100 types of integral outer membrane proteins in each Gram negative bacteria. All of these proteins have the same fold—an up-down β-barrel. It has been suggested that all membrane β-barrels other than lysins are homologous. Here we suggest that β-barrels of efflux pumps have converged on this fold as well. By grouping structurally-solved outer membrane β-barrels (OMBBs) by sequence we find evidence that the membrane environment may have led to convergent evolution of the barrel fold. Specifically, the lack of sequence linkage to other barrels coupled with distinctive structural differences, such as differences in strand tilt and barrel radius, suggest that efflux pumps have evolutionarily converged on the barrel. Finally, we find a possible ancestor for the OMBB efflux pumps as they are related to periplasmic components of the same pumps.
    Description
    Preprint now published in Structure doi: 10.1016/j.str.2018.06.007
    URI
    http://hdl.handle.net/1808/29354
    DOI
    https://doi.org/10.1101/268029
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    • Molecular Biosciences Scholarly Works [572]

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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