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Molecular Biosciences: Recent submissions
Now showing items 161-180 of 887
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Structure and Function of Podovirus Sf6 Tail Complex
(University of Kansas, 2018-05-31)Sf6 is a double-stranded DNA (dsDNA) bacteriophage with a short, non-contractile tail. The tail is a sophisticated molecular machine made of 39 copies of four gene products, including the dodecameric tail adaptor gp7, the ... -
exc-2, an intermediate filament gene, maintains tubular excretory canals in Caenorhabditis elegans along with ifa-4 and other novel genes.
(University of Kansas, 2018-05-31)The excretory canals of Caenorhabditis elegans are a model for understanding the maintenance of apical morphology in narrow single-celled tubes. Light and electron microscopy shows that mutants in exc-2 start to form canals ... -
Naturally Segregating Variation at Ugt86Dd Contributes to Nicotine Resistance in Drosophila melanogaster
(ASTM International, 2017-07-10)Identifying the sequence polymorphisms underlying complex trait variation is a key goal of genetics research, since knowing the precise causative molecular events allows insight into the pathways governing trait variation. ... -
A study of rennin action
(University of Kansas, 1927) -
Identification of novel small molecule Beclin 1 mimetics activating autophagy
(Impact Journals, 2017-05-18)Anti-apoptotic proteins Bcl-2 and Bcl-xL could block autophagy by binding to Beclin 1 protein, an essential inducer of autophagy. Compounds mimicking Beclin 1 might be able to disrupt Bcl-xL/2-Beclin 1 interaction, free ... -
HuR-targeted small molecule inhibitor exhibits cytotoxicity towards human lung cancer cells
(Nature Research, 2017-08-30)Human antigen (Hu) R is an RNA-binding protein whose overexpression in human cancer correlates with aggressive disease, drug resistance, and poor prognosis. HuR inhibition has profound anticancer activity. Pharmacologic ... -
Human oncoprotein Musashi-2 N-terminal RNA recognition motif backbone assignment and identification of RNA-binding pocket
(Impact Journals, 2017-11-20)RNA-binding protein Musashi-2 (MSI2) is a key regulator in stem cells, it is over-expressed in a variety of cancers and its higher expression is associated with poor prognosis. Like Musashi-1, it contains two N-terminal ... -
The fungal natural product azaphilone-9 binds to HuR and inhibits HuR-RNA interaction in vitro
(Public Library of Science, 2017-04-17)The RNA-binding protein Hu antigen R (HuR) binds to AU-rich elements (ARE) in the 3’-untranslated region (UTR) of target mRNAs. The HuR-ARE interactions stabilize many oncogenic mRNAs that play important roles in tumorigenesis. ... -
Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus
(BMC, 2017-02-14)Background The fungal genus Aspergillus is of critical importance to humankind. Species include those with industrial applications, important pathogens of humans, animals and crops, a source of potent carcinogenic ... -
Flavin monooxygenases regulate Caenorhabditis elegans axon guidance and growth cone protrusion with UNC-6/Netrin signaling and Rac GTPases
(Public Library of Science, 2017-08-31)The guidance cue UNC-6/Netrin regulates both attractive and repulsive axon guidance. Our previous work showed that in C. elegans, the attractive UNC-6/Netrin receptor UNC-40/DCC stimulates growth cone protrusion, and that ... -
Studies on isohemagglutination
(University of Kansas, 1929) -
The Activity of Phosphorylase Kinase Revisited
(University of Kansas, 2018-05-31)Phosphorylase Kinase (PhK) is an essential regulatory enzyme in the glycogenolysis cascade. PhK is a large, 16-subunit enzyme complex with the subunit stoichiometry (alpha-beta-gamma-delta)4, and is subject to extensive ... -
Modeling the in vitro aggregation of 4R tau isoforms for a comparative study of FTDP-17 mutants
(University of Kansas, 2017-12-31)Tau is a microtubule binding protein typically found in neuronal axons. In an adult human brain, six isoforms of tau are generated by alternate mRNA splicing. These isoforms of tau differ from each other either based on ... -
O-GlcNAc Regulation of Mitochondrial Function and Energy Metabolism
(University of Kansas, 2017-05-31)O-GlcNAc is a post-translational modification (PTM) of a single N-acetylglucosamine sugar attachment on serine or threonine residues of nuclear, cytoplasmic, and mitochondrial proteins. Two opposing enzymes facilitate the ... -
Studies in experimental anaphylaxis
(University of Kansas, 1929) -
Immunological studies on Bacterium tularense
(University of Kansas, 1950) -
Experimental investigations on the respiration and pathogenesis of typhus fever rickettsiae
(University of Kansas, 1950) -
Non-Catalytic Roles of the Topoisomerase IIα C-Terminal Domain
(MDPI, 2017)DNA Topoisomerase II (Topo II ) is a ubiquitous enzyme in eukaryotes that performs the strand passage reaction where a double helix of DNA is passed through a second double helix. This unique reaction is critical for ... -
Identification of a new small ubiquitin-like modifier (SUMO)-interacting motif in the E3 ligase PIASy
(American Society for Biochemistry and Molecular Biology, 2017)Small ubiquitin-like modifier (SUMO) conjugation is a reversible post-translational modification process implicated in the regulation of gene transcription, DNA repair, and cell cycle. SUMOylation depends on the sequential ... -
Immunogenic properties for the white mouse of various strains of Bacterium tularense
(University of Kansas, 1949)