Pharmacy, School of: Recent submissions
Now showing items 41-60 of 417
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Development of a Unique Student Pharmacist Internship in a Primary Care Provider System
(MDPI, 2019-04-13)Purpose: To describe a unique pharmacy intern program in a group of federally qualified health center (FQHC) outpatient primary care provider clinics. Summary: A pharmacy intern program was created at the North Central ... -
In vivo measurement of enhanced agouti-related peptide release in the paraventricular nucleus of the hypothalamus through Gs activation of agouti-related peptide neurons
(POL Scientific, 2019-07-04)Agouti-related peptide (AgRP) neurons of the hypothalamus play a role in hunger-triggered food intake, stability of body weight, and long-term energy balance. A recent study showed that activation of the Gs-linked G ... -
A network pharmacology-based study on the anti-hepatoma effect of Radix Salviae Miltiorrhizae
(BMC, 2019-08-06)Background Radix Salviae Miltiorrhizae (RSM), a well-known traditional Chinese medicine, has been shown to inhibit tumorigenesis in various human cancers. However, the anticancer effects of RSM on human hepatocellular ... -
The Steroidogenesis Inhibitor Finasteride Reduces the Response to Both Stressful and Rewarding Stimuli
(MDPI, 2019-11-19)Finasteride (FIN) is the prototypical inhibitor of steroid 5α-reductase (5αR), the enzyme that catalyzes the rate-limiting step of the conversion of progesterone and testosterone into their main neuroactive metabolites. ... -
Selenium and the Methionine Sulfoxide Reductase System
(MDPI, 2009-07-01)Selenium is a chemical element participating in the synthesis of selenocysteine residues that play a pivotal role in the enzymatic activity efficiency of selenoproteines. The methionine sulfoxide reductase (Msr) system ... -
In vivo measurement of enhanced agouti-related peptide release in the paraventricular nucleus of the hypothalamus through Gs activation of agouti-related peptide neurons
(POL Scientific, 2019-07-04)Agouti-related peptide (AgRP) neurons of the hypothalamus play a role in hunger-triggered food intake, stability of body weight, and long-term energy balance. A recent study showed that activation of the Gs-linked G ... -
The Functions of the Mammalian Methionine Sulfoxide Reductase System and Related Diseases
(MDPI, 2018-09-18)This review article describes and discusses the current knowledge on the general role of the methionine sulfoxide reductase (MSR) system and the particular role of MSR type A (MSRA) in mammals. A powerful tool to investigate ... -
Relative Selectivity of Plant Cardenolides for Na+/K+-ATPases From the Monarch Butterfly and Non-resistant Insects
(Frontiers Media, 2018-09-28)A major prediction of coevolutionary theory is that plants may target particular herbivores with secondary compounds that are selectively defensive. The highly specialized monarch butterfly (Danaus plexippus) copes well ... -
Double deletion of PINK1 and Parkin impairs hepatic mitophagy and exacerbates acetaminophen-induced liver injury in mice
(Elsevier, 2019-02-20)Mitochondria damage plays a critical role in acetaminophen (APAP)-induced necrosis and liver injury. Cells can adapt and protect themselves by removing damaged mitochondria via mitophagy. PINK1-Parkin pathway is one of the ... -
Conditional knockout of UBC13 produces disturbances in gait and spontaneous locomotion and exploration in mice
(Nature Research, 2019-03-13)Here we have characterized the functional impairments resulting from conditional knockout of the ubiquitin-conjugating E2 enzyme (UBC13) in rodent cerebellar granule neurons, which greatly increases the parallel fiber ... -
Dual Effects of Chinese Herbal Medicines on Angiogenesis in Cancer and Ischemic Stroke Treatments: Role of HIF-1 Network
(Frontiers Media, 2019-06-26)Hypoxia-inducible factor-1 (HIF-1)–induced angiogenesis has been involved in numerous pathological conditions, and it may be harmful or beneficial depending on the types of diseases. Exploration on angiogenesis has sparked ... -
A network pharmacology-based study on the anti-hepatoma effect of Radix Salviae Miltiorrhizae
(BMC, 2019-08-06)Background Radix Salviae Miltiorrhizae (RSM), a well-known traditional Chinese medicine, has been shown to inhibit tumorigenesis in various human cancers. However, the anticancer effects of RSM on human hepatocellular ... -
The Antioxidant Enzyme Methionine Sulfoxide Reductase A (MsrA) Interacts with Jab1/CSN5 and Regulates Its Function
(MDPI, 2020-05-24)Methionine sulfoxide (MetO) is an oxidative posttranslational modification that primarily occurs under oxidative stress conditions, leading to alteration of protein structure and function. This modification is regulated ... -
Extracellular vesicles: Novel communicators in lung diseases
(BMC, 2020-07-08)The lung is the organ with the highest vascular density in the human body. It is therefore perceivable that the endothelium of the lung contributes significantly to the circulation of extracellular vesicles (EVs), which ... -
Genipin suppression of growth and metastasis in hepatocellular carcinoma through blocking activation of STAT-3
(BMC, 2020-08-02)Background The signal transducer and activator of transcription-3 (STAT-3) can facilitate cancer progression and metastasis by being constitutively active via various signaling. Abundant evidence has indicated that STAT-3 ... -
TOMM40 ‘523 associations with baseline and longitudinal cognition in APOEε3 homozygotes
(IOS Press, 2019-08-20)TOMM40 ‘523 is associated with Alzheimer’s disease (AD), but APOE linkage disequilibrium confounds this association. In 170 APOE ε3 homozygotes, we evaluated relationships between short and very long TOMM40 alleles and ... -
Acetylshikonin Sensitizes Hepatocellular Carcinoma Cells to Apoptosis through ROS-Mediated Caspase Activation
(MDPI, 2019-11-19)The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has shown strong and explicit cancer cell-selectivity, which results in little toxicity toward normal tissues, and has been recognized as a potential, ... -
NMDA Receptor in Vasopressin 1b Neurons Is Not Required for Short-Term Social Memory, Object Memory or Aggression
(Frontiers Media, 2019-11-08)The arginine vasopressin 1b receptor (Avpr1b) plays an important role in social behaviors including aggression, social learning and memory. Genetic removal of Avpr1b from mouse models results in deficits in aggression and ... -
Exploring the active mechanism of berberine against HCC by systematic pharmacology and experimental validation
(Spandidos Publications, 2019-09-23)Berberine (BBR) is the main component of Coptidis rhizoma, the dried rhizome of Coptis chinensis and is a potential plant alkaloid used for the treatment of cancer due to its high antitumor activity. The present study ... -
Bioenergetic Regulation of Neuronal Vacuolar-type H+- ATPase
(University of Kansas, 2019-12-31)Neuronal vacuolar-type H+-ATPase (V-ATPase) is an ATP-dependent proton pump that functions to acidify intracellular organelles such as lysosomes and synaptic vesicles, creating a proton gradient by which neurotransmitters ...