Extracellular vesicles: Novel communicators in lung diseases
View/ Open
Issue Date
2020-07-08Author
Mohan, Aradhana
Agarwal, Stuti
Clauss, Matthias
Britt, Nicholas S.
Dhillon, Navneet K.
Publisher
BMC
Type
Article
Article Version
Scholarly/refereed, publisher version
Rights
Copyright © 2020, The Author(s)
Metadata
Show full item recordAbstract
The lung is the organ with the highest vascular density in the human body. It is therefore perceivable that the endothelium of the lung contributes significantly to the circulation of extracellular vesicles (EVs), which include exosomes, microvesicles, and apoptotic bodies. In addition to the endothelium, EVs may arise from alveolar macrophages, fibroblasts and epithelial cells. Because EVs harbor cargo molecules, such as miRNA, mRNA, and proteins, these intercellular communicators provide important insight into the health and disease condition of donor cells and may serve as useful biomarkers of lung disease processes. This comprehensive review focuses on what is currently known about the role of EVs as markers and mediators of lung pathologies including COPD, pulmonary hypertension, asthma, lung cancer and ALI/ARDS. We also explore the role EVs can potentially serve as therapeutics for these lung diseases when released from healthy progenitor cells, such as mesenchymal stem cells.
Description
This work is licensed under a Creative Commons Attribution 4.0 International License.
Collections
- Pharmacy Scholarly Works [293]
Citation
Mohan, A., Agarwal, S., Clauss, M., Britt, N. S., & Dhillon, N. K. (2020). Extracellular vesicles: novel communicators in lung diseases. Respiratory research, 21(1), 175. https://doi.org/10.1186/s12931-020-01423-y
Items in KU ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
We want to hear from you! Please share your stories about how Open Access to this item benefits YOU.