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    TOMM40 ‘523 associations with baseline and longitudinal cognition in APOEε3 homozygotes

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    Issue Date
    2019-08-20
    Author
    Watts, Amber
    Wilkins, Heather M.
    Michaelis, Elias
    Swerdlow, Russell H.
    Publisher
    IOS Press
    Type
    Article
    Article Version
    Scholarly/refereed, author accepted manuscript
    Rights
    Copyright The Authors (2019)
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    Abstract
    TOMM40 ‘523 is associated with Alzheimer’s disease (AD), but APOE linkage disequilibrium confounds this association. In 170 APOE ε3 homozygotes, we evaluated relationships between short and very long TOMM40 alleles and longitudinal declines in three cognitive domains (attention, verbal memory, and executive function). We used factor analysis to create composite scores from 10 individual cognitive tests, and latent growth curve modeling adjusting for clinical status (normal, amnestic mild cognitive impairment, or AD) to summarize initial performance and change over three years. Relative to individuals with two very long TOMM40 alleles, APOE ε3 homozygotes with one or two short alleles showed lower baseline cognitive performance regardless of clinical status. The number of short or very long TOMM40 alleles was not associated with longitudinal cognitive changes. In APOE ε3 homozygotes from the KUADC cohort, an association between TOMM40 ‘523 and cognition is consistent with the possibility that TOMM40 influences cognition independent of APOE.
    URI
    http://hdl.handle.net/1808/30783
    DOI
    https://doi.org/10.3233/JAD-190293
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    • Psychology Scholarly Works [246]
    Citation
    Watts, A., Wilkins, H. M., Michaelis, E., & Swerdlow, R. H. (2019). TOMM40 '523 Associations with Baseline and Longitudinal Cognition in APOE ɛ3 Homozygotes. Journal of Alzheimer's disease : JAD, 70(4), 1059–1068. https://doi.org/10.3233/JAD-190293

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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