Pharmacy, School of: Recent submissions
Now showing items 21-40 of 417
-
Inducing Partner Preference in Mice by Chemogenetic Stimulation of CA2 Hippocampal Subfield
(Frontiers Media, 2020-04-23)Social recognition is fundamental for social decision making and the establishment of long-lasting affiliative behaviors in behaviorally complex social groups. It is a critical step in establishing a selective preference ... -
Facing Real-World Challenges of Immunogenicity in Pediatric Inflammatory Bowel Disease
(Frontiers Media, 2020-06-09)The advent of biological therapies drastically altered the landscape of inflammatory bowel disease (IBD) treatment, making long-term steroid-free remission possible for thousands of patients living with this chronic ... -
Immunogenicity in Clinical Practice and Drug Development: When is it Significant?
(Wiley Open Access, 2019-11-25)Managing immunogenicity in clinical practice and during drug development was a recent topic at the ASCPT 2019 annual meeting. This commentary expands on the discussion to facilitate a broader engagement across the community. ... -
What drugs modify the risk of iatrogenic impulse-control disorders in Parkinson’s disease? A preliminary pharmacoepidemiologic study
(Public Library of Science, 2020-01-07)Introduction Parkinson’s disease (PD) patients treated with pramipexole (PPX) and ropinirole (ROP) exhibit a higher risk of developing impulse control disorders (ICDs), including gambling disorder, compulsive shopping, ... -
The accuracy and completeness of drug information in Google snippet blocks
(Medical Library Association, 2021-10-01)Introduction: Consumers commonly use the Internet for immediate drug information. In 2014, Google introduced the snippet block to programmatically search available websites to answer a question entered into the search ... -
Regulation of Serotonin 1A Receptor SUMOylation by SENP2 and PIASxα
(MDPI, 2021-12-07)Serotonin 1A receptors (5-HT1ARs) are implicated in the control of mood, cognition, and memory and in various neuropsychiatric disorders such as depression and anxiety. As such, understanding the regulation of 5-HT1ARs ... -
Discovery of sultam-containing small-molecule disruptors of the huntingtin–calmodulin protein–protein interaction
(Springer, 2020-06-12)The aberrant protein–protein interaction between calmodulin and mutant huntingtin protein in Huntington’s disease patients has been found to contribute to Huntington’s disease progression. A high-throughput screen for small ... -
Clusterin: A multifaceted protein in the brain
(Medknow Publications, 2020-12-12) -
Synaptic Loss in Alzheimer's Disease: Mechanistic Insights Provided by Two-Photon in vivo Imaging of Transgenic Mouse Models
(Frontiers Media, 2020-12-21)Synapse loss is the strongest correlate for cognitive decline in Alzheimer's disease. The mechanisms underlying synapse loss have been extensively investigated using mouse models expressing genes with human familial ... -
TREM2 Mediates Microglial Anti-Inflammatory Activations in Alzheimer’s Disease: Lessons Learned from Transcriptomics
(MDPI, 2021-02-04)Alzheimer’s disease (AD) is a lethal neurodegenerative disorder primarily affecting the aged population. The etiopathogenesis of AD, especially that of the sporadic type, remains elusive. The triggering receptor expressed ... -
Mitochondrial Permeability Transition: A Pore Intertwines Brain Aging and Alzheimer’s Disease
(MDPI, 2021-03-15)Advanced age is the greatest risk factor for aging-related brain disorders including Alzheimer’s disease (AD). However, the detailed mechanisms that mechanistically link aging and AD remain elusive. In recent years, a ... -
Editorial: Synaptic Loss and Neurodegeneration
(Frontiers Media, 2021-04-21) -
Mitochondrial ferritin attenuates cerebral ischaemia/reperfusion injury by inhibiting ferroptosis
(Springer Nature, 2021-05-05)Ischaemic stroke is becoming the most common cerebral disease in aging populations, but the underlying molecular mechanism of the disease has not yet been fully elucidated. Increasing evidence has indicated that an excess ... -
Glycolytic Metabolism, Brain Resilience, and Alzheimer’s Disease
(Frontiers Media, 2021-04-28)Alzheimer’s disease (AD) is the most common form of age-related dementia. Despite decades of research, the etiology and pathogenesis of AD are not well understood. Brain glucose hypometabolism has long been recognized as ... -
Resveratrol Derivative, Trans-3, 5, 4-Trimethoxystilbene Sensitizes Osteosarcoma Cells to Apoptosis via ROS-Induced Caspases Activation
(Hindawi, 2021-03-26)Numerous studies have shown that resveratrol can induce apoptosis in cancer cells. Trans-3, 5, 4-trimethoxystilbene (TMS), a novel derivative of resveratrol, is a more potent anticancer compound than resveratrol and can ... -
Sialometabolism in Brain Health and Alzheimer’s Disease
(Nature Research, 2021-03-30)Sialic acids refer to a unique family of acidic sugars with a 9-carbon backbone that are mostly found as terminal residues in glycan structures of glycoconjugates including both glycoproteins and glycolipids. The highest ... -
Editorial: The Oxytocin System in Fear, Stress, Anguish, and Pain
(Frontiers Media, 2021-07-20) -
Identification of adverse drug-drug interactions through causal association rule discovery from spontaneous adverse event reports
(Elsevier, 2017-02-10)Objective Drug-drug interaction (DDI) is of serious concern, causing over 30% of all adverse drug reactions and resulting in significant morbidity and mortality. Early discovery of adverse DDI is critical to prevent patient ... -
A nationwide survey of pharmacy students’ knowledge and perceptions regarding medical cannabis
(Elsevier, 2019-08-28)Objective The primary objective of this study was to compare knowledge and perceptions of medical cannabis (MC) between pharmacy students who attended schools where MC was legal and illegal. Design A nationwide anonymous ... -
Impact of community pharmacist intervention on concurrent benzodiazepine and opioid prescribing patterns
(Elsevier, 2018-10-17)Objectives (1) To evaluate the number of opioid/benzodiazepine (BZD) prescription changes resulting from pharmacist communication to prescriber(s); (2) to determine the number of patients on concurrent opioid/BZD therapy ...