Pharmacy, School of: Recent submissions
Now showing items 141-160 of 417
-
Clearance and Phosphorylation of Alpha-Synuclein Are Inhibited in Methionine Sulfoxide Reductase A Null Yeast Cells
(Humana Press, 2009-11)Aggregated α-synuclein and the point mutations Ala30Pro and Ala53Thr of α-synuclein are associated with Parkinson’s disease. The physiological roles of α-synuclein and methionine oxidation of the α-synuclein protein structure ... -
Dopamine D2 receptor function is compromised in the brain of the methionine sulfoxide reductase A knockout mouse
(Wiley, 2010-07)Previous research suggests that brain oxidative stress and altered rodent locomotor behavior are linked. We observed bio-behavioral changes in methionine sulfoxide reductase A knockout mice associated with abnormal dopamine ... -
Decreases in Plasma Membrane Ca2+-ATPase in Brain Synaptic Membrane Rafts from Aged Rats
(Wiley, 2012-12)Precise regulation of free intracellular Ca2+ concentrations [Ca2+]i is critical for normal neuronal function, and alterations in Ca2+ homeostasis are associated with brain aging and neurodegenerative diseases. One of the ... -
Bone Marrow Transplantation Augments the Effect of Brain- and Spinal Cord-Directed Adeno-Associated Virus 2/5 Gene Therapy by Altering Inflammation in the Murine Model of Globoid-Cell Leukodystrophy
(Society for Neuroscience, 2011-07-06)Globoid-cell leukodystrophy (GLD) is an inherited demyelinating disease caused by the deficiency of the lysosomal enzyme galactosylceramidase (GALC). A previous study in the murine model of GLD (twitcher) demonstrated a ... -
Sensorimotor Behavioral Tests for Use in a Juvenile Rat Model of Traumatic Brain Injury: Assessment of Sex Differences
(Elsevier, 2011-08-15)Modeling juvenile traumatic brain injury (TBI) in rodents presents several unique challenges compared to adult TBI, one of which is selecting appropriate sensorimotor behavioral tasks that enable the assessment of the ... -
Methylphenidate Attenuates Rats' Preference for a Novel Spatial Stimulus Introduced into a Familiar Enviroment: Assessment Using a Force Plate Actometer
(Elsevier, 2010-03-30)Methylphenidate is a psychostimulant widely used in the treatment of attention deficit hyperactivity disorder (ADHD). Here we report a novel paradigm that affords inferences about habituation and attention to a novel ... -
Gene by Environment Interaction Leads to Sensitivity to the Anti-Aggressive Effect of Δ9-Tetrahydrocannabinol
(University of Kansas, 2016-12-31)Pathological reactive aggression is a neurodevelopmental disorder characterized by exaggerated violent and explosive responses that are disproportionate to provocation, and a propensity for cannabis abuse. The susceptibility ... -
Animal models of tic disorders: A translational perspective
(Elsevier, 2014-12-30)Tics are repetitive, sudden movements and/or vocalizations, typically enacted as maladaptive responses to intrusive premonitory urges. The most severe tic disorder, Tourette syndrome (TS), is a childhood-onset condition ... -
Hyperactivity in the Gunn rat model of neonatal jaundice: age-related attenuation and emergence of gait deficits
(Nature Publishing Group, 2014-12-17)Background Neonatal jaundice resulting from elevated unconjugated bilirubin (UCB) occurs in 60–80% of newborn infants. Although mild jaundice is generally considered harmless, little is known about its long-term ... -
Within-Session Analysis of Amphetamine-Elicited Rotation Behavior Reveals Differences between Young Adult and Middle-Aged F344/BN Rats with Partial Unilateral Striatal Dopamine Depletion
(Elsevier, 2010-07-01)Preclinical modeling of Parkinson's disease using 6-hydroxydopamine (6-OHDA) has been valuable in developing and testing therapeutic strategies. Recent efforts have focused on modeling early stages of disease by infusing ... -
Regulation of Motor Function and Behavior by Atypical Chemokine Receptor 1
(Springer Verlag, 2014-09)Atypical Chemokine Receptor 1 (ACKR1), previously known as the Duffy Antigen Receptor for Chemokines, stands out among chemokine receptors for its high selective expression on Purkinje cells of the cerebellum, consistent ... -
Use of a force-sensing automated open field apparatus in a longitudinal study of multiple behavioral deficits in CAG140 Huntington's Disease model mice
(Elsevier, 2015-11-01)Behavioral testing of mouse models of Huntington's disease (HD) is a key component of preclinical assessment for potential pharmacological intervention. An open field with a force plate floor was used to quantify numerous ... -
Identification, Ki determination and CoMFA analysis of nuclear receptor ligands as competitive inhibitors of OATP1B1-mediated estradiol-17β-glucuronide transport
(Elsevier, 2009-03-17)Evidence shows that drug-drug interactions can occur at the level of drug transporters such as the organic anion transporting polypeptides (OATPs), a group of membrane solute carriers that mediate the sodium-independent ... -
Post-translational Modification of Pregnane X Receptor
(Elsevier, 2011-03-21)Pregnane x receptor (PXR, NR1I2) was originally characterized as a broad spectrum entero-hepatic xenobiotic ‘sensor’ and master-regulator of drug inducible gene expression. A compelling description of ligand-mediated gene ... -
DEVELOPMENTAL EFFECTS OF DIETARY N-3 FATTY ACIDS ON ACTIVITY AND RESPONSE TO NOVELTY
(Elsevier, 2010-05-10)Insufficient availability of n-3 polyunsaturated fatty acids (PUFA) during pre- and neonatal development decreases accretion of docosahexaenoic acid (DHA, 22:6n-3) in the developing brain. Low tissue levels of DHA are ... -
Repeated administration of phytocannabinoid Δ9-THC or synthetic cannabinoids JWH-018 and JWH-073 induces tolerance to hypothermia but not locomotor suppression in mice, and reduces CB1 receptor expression and function in a brain region-specific manner
(Elsevier, 2015-09-08)These studies probed the relationship between intrinsic efficacy and tolerance / cross-tolerance between Δ9-THC and synthetic cannabinoid drugs of abuse (SCBs) by examining in vivo effects and cellular changes concomitant ... -
MECHANISTIC ASPECTS OF CAROTENOID BIOSYNTHESIS
(ACS, 2014-01-08) -
Alterations in bile acid homeostasis and drug metabolism in germ-free mice
(University of Kansas, 2014-08-31)"We may be born 100% human but will die 90% bacterial--a truly complex organism!" (Goodacre, 2007). This statement reflects the fact that there are 10 times more bacterial cells in the human body compared to the number of ... -
Novologue Therapy Improves Mitochondrial Bioenergetics and Modulates Transcriptome Changes in Diabetic Sensory Neurons
(University of Kansas, 2015-05-31)Diabetic peripheral neuropathy (DPN) is a prevalent diabetic complication with scarce treatment options. Impaired neuronal mitochondrial bioenergetics contributes to the pathophysiologic progression of DPN and may be a ... -
DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway
(Nature Publishing Group, 2016-10-24)Stabilization of mutant p53 (mutp53) in tumours greatly contributes to malignant progression. However, little is known about the underlying mechanisms and therapeutic approaches to destabilize mutp53. Here, through ...