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    Hyperactivity in the Gunn rat model of neonatal jaundice: age-related attenuation and emergence of gait deficits

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    fowler_hyperactivity.pdf (449.4Kb)
    Issue Date
    2014-12-17
    Author
    Stanford, John A.
    Shuler, Jeffrey M.
    Fowler, Stephen C.
    Stanford, Kimberly G.
    Ma, Delin
    Bittel, Douglas C.
    Le Pichon, Jean-Baptiste
    Publisher
    Nature Publishing Group
    Type
    Article
    Article Version
    Scholarly/refereed, author accepted manuscript
    Published Version
    https://www.nature.com/pr/journal/v77/n3/full/pr2014199a.html
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    Abstract
    Background

    Neonatal jaundice resulting from elevated unconjugated bilirubin (UCB) occurs in 60–80% of newborn infants. Although mild jaundice is generally considered harmless, little is known about its long-term consequences. Recent studies have linked mild bilirubin-induced neurological dysfunction (BIND) with a range of neurological syndromes, including attention deficit-hyperactivity disorder. The goal of this study was to measure BIND across the lifespan in the Gunn rat model of BIND.

    Methods

    Using a sensitive force plate actometer, we measured locomotor activity and gait in jaundiced (jj) Gunn rats versus their non-jaundiced (Nj) littermates. Data were analyzed for young adult (3–4 months), early middle-aged (9–10 months), and late middle-aged (17–20 months) male rats.

    Results

    jj rats exhibited lower body weights at all ages and a hyperactivity that resolved at 17–20 months of age. Increased propulsive force and gait velocity accompanied hyperactivity during locomotor bouts at 9–10 months in jj rats. Stride length did not differ between the two groups at this age. Hyperactivity normalized and gait deficits, including decreased stride length, propulsive force, and gait velocity, emerged in the 17–20-month-old jj rats.

    Conclusions

    These results demonstrate that, in aging, hyperactivity decreases with the onset of gait deficits in the Gunn rat model of BIND.
    URI
    http://hdl.handle.net/1808/24091
    DOI
    https://doi.org/10.1038/pr.2014.199
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    • Pharmacy Scholarly Works [280]
    Citation
    Stanford, John A. et al. “Hyperactivity in the Gunn Rat Model of Neonatal Jaundice: Age-Related Attenuation and Emergence of Gait Deficits.” Pediatric research 77.3 (2015): 434–439.

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    KU Libraries
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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