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    Regulation of Motor Function and Behavior by Atypical Chemokine Receptor 1

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    Schneider_Springer_2014.pdf (3.839Mb)
    Issue Date
    2014-09
    Author
    Schneider, Erich H.
    Fowler, Stephen C.
    Lionakis, Michail S.
    Swamydas, Muthulekha
    Holmes, Gibran
    Diaz, Vivian
    Munasinghe, Jeeva
    Peiper, Stephen C.
    Gao, Ji-Liang
    Murphy, Philip M.
    Publisher
    Springer Verlag
    Type
    Article
    Article Version
    Scholarly/refereed, author accepted manuscript
    Rights
    © Springer Science+Business Media New York (outside the USA) 2014
    Metadata
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    Abstract
    Atypical Chemokine Receptor 1 (ACKR1), previously known as the Duffy Antigen Receptor for Chemokines, stands out among chemokine receptors for its high selective expression on Purkinje cells of the cerebellum, consistent with the ability of ACKR1 ligands to activate Purkinje cells in vitro. Nevertheless, evidence for ACKR1 regulation of brain function in vivo has been lacking. Here we demonstrate that Ackr1−/− mice have markedly impaired balance and ataxia when placed on a rotating rod and increased tremor when injected with harmaline, a drug that induces whole-body tremor by activating Purkinje cells. Ackr1−/− mice also exhibited impaired exploratory behavior, increased anxiety-like behavior and frequent episodes of marked hypoactivity under low-stress conditions. The behavioral phenotype of Ackr1−/− mice was the opposite of the phenotype occurring in mice with cerebellar degeneration and the defects persisted when Ackr1 was deficient only on non-hematopoietic cells. We conclude that normal motor function and behavior depend in part on negative regulation of Purkinje cell activity by Ackr1.
    Description
    The final publication is available at Springer via http://dx.doi.org/10.1007/s10519-014-9665-7
    URI
    http://hdl.handle.net/1808/24068
    DOI
    https://doi.org/10.1007/s10519-014-9665-7
    Collections
    • Pharmacy Scholarly Works [240]
    Citation
    Schneider, E. H., Fowler, S. C., Lionakis, M. S., Swamydas, M., Holmes, G., Diaz, V., … Murphy, P. M. (2014). Regulation of Motor Function and Behavior by Atypical Chemokine Receptor 1. Behavior Genetics, 44(5), 498–515. http://doi.org/10.1007/s10519-014-9665-7

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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