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Chemistry: Recent submissions
Now showing items 921-940 of 964
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Fabrication and Optimization of a 25µm Glucose Sensor
(University of Kansas, 2009-12-08)Microelectrodes have been used for over 30 years of glucose biosensor history. Two different types of glucose biosensors were developed using 176um and 25um diameter Pt wire cylindrical microelectrodes. The 176 um Pt wire ... -
Development of an online microdialysis-microchip electrophoresis system for near real time monitoring of amino acids
(University of Kansas, 2009-01-01)The brain extracellular space is complex chemical environment consisting of ions, peptides, neurotransmitters, growth factors, metabolites and extracellular matrix molecules. Microdialysis is a popular and well-characterized ... -
Biochemical Characterization and Structure Determination of a Prolyl 4-Hydroxylase-like Protein from Bacillus anthracis
(University of Kansas, 2009-06-05)Procollagen prolyl-4-hydroxylase (P4H) catalyzes the conversion of peptidyl proline to trans-4-hydroxyproline (Hyp). P4H is a member of the alpha-ketoglutarate-dependent mononuclear non-heme iron oxygenase (alphaKG/Fe(II ... -
Dopaquinone as a Common Intermediate in the Biogenesis of Tyrosine-Derived Quinone Cofactors
(University of Kansas, 2009-06-16)Copper amine oxidases (CAOs) are essential for maintaining the level of biogenic amines in the body as well as being involved in the inflammation and immune responses. Lysyl oxidase (LOX), a member of CAO, plays an important ... -
GLYCOPEPTIDE ANALYSIS OF HIV-1 ENVELOPE PROTEIN USING HPLC/ESI-FTICR MS AND MALDI-TOF MS WITH ASIALOFETUIN ENRICHMENT AND SEPARATION TECHNIQUES
(University of Kansas, 2009-04-28)Glycosylation on proteins serve many biological roles and their heterogeneity can affect various biological functions. The site occupancy of the glycans as well as their various glycoforms makes glycans unique to analyze ... -
Development of Novel Transition Metal Catalyzed Transformations Involving Small, Strained Carbocycles
(University of Kansas, 2009-01-01)This document deals with 3-membered carbocycles; their use as ligands for the asymmetric Heck reaction (AHR), the development of novel methods for their synthesis, and reactions for their further functionalization. The ... -
Design of Novel Electron-Rich Organometallic Frameworks Involving Metal-Isocyanide Junctions
(University of Kansas, 2009-01-01)Aromatic diisocyanides are extensively employed as building blocks in coordination and surface chemistry as charge transport mediators for nanotechnology applications. The first diisocyanoarene-bridged bimetallate system, ... -
Optimization and Applications of Fluorescence anisotropy assays and Fluorescence Resonance Energy Transfer Measurements
(University of Kansas, 2009-01-01)Calmodulin (CaM) is a calcium signaling protein that activates over hundred of targets including PMCA. This dissertation mainly focuses on optimizing and applications of fluorescence anisotropy (FA) and FRET experiments ... -
Palladacycles with Palladium-Bonded Stereogenic Carbons: Tools for Exploring Reaction Pathways in Organometallic Chemistry
(University of Kansas, 2009-01-01)While reactions with organopalladium intermediates often give useful organic products, little is known about how the ligand sphere impacts the reactivity of these intermediates. To explore the interactions between the ... -
Metalloproteins: Structure Determination (HADH), Inhibition (P4H), and Biomimetic Systems (P-1[Ru(NO)(Cl)])
(University of Kansas, 2008-01-01)Histamine dehydrogenase from Nocardioides simplex (HADH) is a flavoprotein that converts histamine to imidazole acetaldehyde and is highly specific for histamine. Chapter one describes the development of overexpression and ... -
Tissue-Targeted Metabonomics: Metabolic Profiling by Microdialysis and NMR Spectroscopy
(University of Kansas, 2008-01-01)This research offers an alternative approach to the study of tissue-specific metabolism by metabonomics, called tissue-targeted metabonomics. Microdialysis sampling was used to sample small endogenous metabolites in tissue ... -
DEVELOPMENT OF FUNCTIONAL NANOPARTICULATE MATERIALS: Examination of the Functional and Structural Properties of Nanoparticulate Metal Complexes Prepared by Precipitation with Compressed Antisolvent Technology
(University of Kansas, 2008-01-01)A diverse set of systems that interact with nitric oxide (NO) is important because of its adverse role in environmental chemistry and importance in mammalian biology. Towards this effort, nanomaterials that interact with ... -
Site-specific analysis of glycosylated proteins using mass spectrometry
(University of Kansas, 2008-01-16)Among the numerous post-translational modifications that a protein can undergo, glycosylation is by far the most common, having the most profound influence on the structural and functional properties of the protein. ... -
CHARACTERIZATION OF HEME OXYGENASE AND FERREDOXIN NADPH REDUCTASE: TWO REDOX PARTNER PROTEINS INVOLVED IN THE HEME-IRON ACQUISITION PATHWAY OF PSEUDOMONAS AERUGINOSA
(University of Kansas, 2008-08-04)The infections from bacterial pathogen Pseudomonas aerugionsa are very difficult to cure and cause premature death of many patients with AIDs, cystic fibrosis and cancer. Bacteria need iron to infect an organism, but the ... -
Development of Multiple Probe Microdialysis Sampling Techniques for Site-Specific Monitoring in the Stomach
(University of Kansas, 2007-12-31)Microdialysis sampling is a technique used extensively to monitor analytes within numerous tissues. Although the capability of implanting multiple probes into a single animal exists, typical experiments are performed using ... -
The Role of the Leaving Group in the Photo-Favorskii Rearrangement of p-Hydroxyphenacyl
(University of Kansas, 2008-07-28)The p-hydroxyphenacyl group has several features that make it an attractive photoremovable protecting group. Literature examples support this statement and the benzoate, formate, and sulfonate derivatives are not exceptions. ... -
Palladium- and Ruthenium-Catalyzed Decarboxylative Allylations and Michael Addition-Allylation Reactions. Applications in Nitrogen Heterocycle Synthesis
(University of Kansas, 2008-08-21)Our group has a long-standing interest in Pd or Ru-catalyzed decarboxylative coupling reactions. It has been shown that allyl ?-ketoesters, upon treatment with palladium or ruthenium, generate freely diffusing enolates and ... -
Charge Transfer Reactions in Porous Materials
(University of Kansas, 2008-08-15)Porous materials, such as sol-gels and zeolites, contain nanometer-scale spaces in which molecules are confined, leading to significant changes in their chemical dynamics. In this dissertation, the effects of confinement ... -
Structure and Dynamic Studies of the Nuclear Pore Complex at the Single-Molecule Level
(University of Kansas, 2008-08-06)Nuclear pore complexes (NPCs) are large macromolecular structures forming the only known direct route across the double bilayer membrane of the nuclear envelope. The NPC structure has been extensively explored in an effort ... -
A Novel Route to Enantioenriched α-Allyl α-Fluoroketones via Palladium Catalyzed Decarboxylation
(University of Kansas, 2008-08-21)This thesis details the development of a novel catalytic asymmetric route to α-fluorinated ketones. Enantioenriched α-fluoroketones were produced in good yields and high enantiomeric ratios via palladium-catalyzed ...