Microelectrodes have been used for over 30 years of glucose biosensor history. Two different types of glucose biosensors were developed using 176um and 25um diameter Pt wire cylindrical microelectrodes. The 176 um Pt wire type microelectrodes were modified with non-conductive polymers and glucose oxidase enzyme. The lifetime of biosensors was over 50 days and had negligible response to interference species such as ascorbate and urate. The 25um Pt wire microelectrode was coated with glucose oxidase and conductive polymer, polypyrrole by chemical polymerization. Nafion® was used to eliminate interferences. The 25 um polypyrrole based glucose sensor had the ability to measure in vivo glucose.
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