Chemistry: Recent submissions
Now showing items 61-80 of 961
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Linear and Differential Ion Mobility Separations of Middle-Down Proteoforms
(American Chemical Society, 2018-01-23)Comprehensive characterization of proteomes comprising the same proteins with distinct post-translational modifications (PTMs) is a staggering challenge. Many such proteoforms are isomers (localization variants) that require ... -
Microfluidic-based solid phase extraction of cell free DNA
(Royal Society of Chemistry, 2018-10-04)Cell-free DNA (cfDNA) is a liquid biopsy marker that can carry signatures (i.e., mutations) associated with certain pathological conditions. Therefore, the extraction of cfDNA from a variety of clinical samples can be an ... -
Two New Tools for Glycopeptide Analysis Researchers: A Glycopeptide Decoy Generator and a Large Data Set of Assigned CID Spectra of Glycopeptides
(American Chemical Society, 2017-07-10)The glycopeptide analysis field is tightly constrained by a lack of effective tools that translate mass spectrometry data into meaningful chemical information, and perhaps the most challenging aspect of building effective ... -
Correction: Directed nucleophilic addition of phenoxides to cyclopropenes
(Royal Society of Chemistry, 2018-07-30)Correction for ‘Directed nucleophilic addition of phenoxides to cyclopropenes’ by Pavel Yamanushkin et al., Org. Biomol. Chem., 2017, 15, 8153–8165. The authors regret that there was an omission in the Acknowledgement ... -
Human lysyl oxidase-like 2
(Elsevier, 2014-08-01)Lysyl oxidase like-2 (LOXL2) belongs to the lysyl oxidase (LOX) family, which comprises Cu2+- and lysine tyrosylquinone (LTQ)-dependent amine oxidases. LOXL2 is proposed to function similarly to LOX in the extracellular ... -
Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis
(American Association for the Advancement of Science, 2018-05-16)Metastasis remains a leading cause of cancer mortality due to the lack of specific inhibitors against this complex process. To identify compounds selectively targeting the metastatic state, we used the perinucleolar ... -
Electrochemical Measurement of Dopamine Release and Uptake in Zebrafish Following Treatment with Carboplatin
(Wiley, 2018-03-23)Post-chemotherapy cognitive impairment, also known as ‘chemobrain,’ is a neurological condition in which cognitive function is impaired as a result of cancer chemotherapy treatment. In this work, we used fast-scan cyclic ... -
Directed RhI-Catalyzed Asymmetric Hydroboration of Prochiral 1-Arylcycloprop-2-Ene-1-Carboxylic Acid Derivatives
(Wiley, 2017-11-13)A full account on rhodium-catalyzed asymmetric, directed hydroboration of functionalized prochiral cyclopropenes affording enantiomerically enriched cyclopropylboronates is reported. The scope and limitations of two alternate ... -
Experimental and Theoretical Study of Resonance Raman Spectroscopy in Ground and Excited Electronic States
(University of Kansas, 2019-12-31)Spectroscopy is a powerful tool for the identification, study, and selective control of molecular processes. Raman scattering is particularly useful in observing the vibrational properties of molecules, and identifying ... -
Dynamic elements and kinetics: Most favorable conformations of peptides in solution with measurements and simulations
(American Institute of Physics, 2019-12-12)Small peptides in solution adopt a specific morphology as they function. It is of fundamental interest to examine the structural properties of these small biomolecules in solution and observe how they transition from one ... -
Kinetic pathway analysis of an α-helix in two protonation states: Direct observation and optimal dimensionality reduction
(American Institute of Physics, 2019-02-21)Thermodynamically stable conformers of secondary structural elements make a stable tertiary/quaternary structure that performs its proper biological function efficiently. Formation mechanisms of secondary and tertiary/quaternary ... -
Electrophilically activated nitroalkanes in reaction with aliphatic diamines en route to imidazolines
(Royal Society of Chemistry, 2019-11-29)A novel synthetic methodology for the assembly of imidazolines via an unusual reaction between nitroalkanes and aliphatic 1,2-diamines in the presence of phosphorous acid is described. In contrast to the related highly ... -
Electrophilic activation of nitroalkanes in efficient synthesis of 1,3,4-oxadiazoles
(Royal Society of Chemistry, 2019-02-26)A novel methodology for general and chemoselective preparation of non-symmetric 1,3,4-oxadiazoles is developed. This unusual reaction proceeds via polyphosphoric acid-assisted activation of nitroalkanes towards nucleophilic ... -
Anion Relay Cyclopropanation and Aryl Vinyl Cyclopropane Cope Rearrangements
(University of Kansas, 2019-08-31)Anion Relay Chemistry is a powerful tool for the rapid development of molecular complexity in an operationally simple manner. Much of the work in this field has been pioneered and developed by the Smith group, whose work ... -
Molecular Simulation of the Passive Permeation of Small Peptides across Lipid Bilayers
(University of Kansas, 2019-08-31)The passive permeation of small peptides across lipid bilayers was studied by using molecular dynamics simulations and umbrella sampling. The knowledge gained in this work furthers our understanding of permeation across ... -
Genetic and Chemical Intervention of the BfrB:Bfd Interaction Dysregulate Iron Homeostasis in Pseudomonas aeruginosa and Affect its Broader Metabolism
(University of Kansas, 2020-05-31)Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen that is accountable for multiple types of infections, including pneumonia, wound, burn, and urinary tract infections. P. aeruginosa is an emerging threat in ... -
Stabilization of the V2 loop improves the presentation of V2 loop–associated broadly neutralizing antibody epitopes on HIV-1 envelope trimers
(American Society for Biochemistry and Molecular Biology, 2019-04-05)A successful HIV-1 vaccine will likely need to elicit broadly neutralizing antibodies (bNAbs) that target the envelope glycoprotein (Env) spike on the virus. Native-like recombinant Env trimers of the SOSIP design now serve ... -
Multiplexed immunophenotyping of circulating exosomes on nano-engineered ExoProfile chip towards early diagnosis of cancer
(Royal Society of Chemistry, 2019-04-22)Circulating exosomes have been studied as a promising biomarker for non-invasive cancer diagnosis, as they are implicated in tumor initiation, progression, and metastasis. However, the clinical significance of circulating ... -
Carnosine Prevents Aβ-Induced Oxidative Stress and Inflammation in Microglial Cells: A Key Role of TGF-β1
(MDPI, 2019-01-17)Carnosine (β-alanyl-L-histidine), a dipeptide, is an endogenous antioxidant widely distributed in excitable tissues like muscles and the brain. Carnosine is involved in cellular defense mechanisms against oxidative stress, ... -
Carnosine Decreases PMA-Induced Oxidative Stress and Inflammation in Murine Macrophages
(MDPI, 2019-08-06)Carnosine is an endogenous dipeptide composed of β-alanine and L-histidine. This naturally occurring molecule is present at high concentrations in several mammalian excitable tissues such as muscles and brain, while it can ...