Human lysyl oxidase-like 2

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Issue Date
2014-08-01Author
Moon, Hee-Jung
Finney, Joel
Ronnebaum, Trey
Mure, Minae
Publisher
Elsevier
Type
Article
Article Version
Scholarly/refereed, author accepted manuscript
Rights
Copyright © 2014 Elsevier Inc. All rights reserved.
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Show full item recordAbstract
Lysyl oxidase like-2 (LOXL2) belongs to the lysyl oxidase (LOX) family, which comprises Cu2+- and lysine tyrosylquinone (LTQ)-dependent amine oxidases. LOXL2 is proposed to function similarly to LOX in the extracellular matrix (ECM) by promoting crosslinking of collagen and elastin. LOXL2 has also been proposed to regulate extracellular and intracellular cell signaling pathways. Dysregulation of LOXL2 has been linked to many diseases, including cancer, pro-oncogenic angiogenesis, fibrosis and heart diseases. In this review, we will give an overview of the current understandings and hypotheses regarding the molecular functions of LOXL2.
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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Citation
Hee-Jung Moon, Joel Finney, Trey Ronnebaum, Minae Mure. Bioorg Chem. 2014 Dec; 57: 231–241. Published online 2014 Aug 1. doi: 10.1016/j.bioorg.2014.07.003
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