Electrophilic activation of nitroalkanes in efficient synthesis of 1,3,4-oxadiazoles

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Issue Date
2019-02-26
Author
Aksenov, Alexander V.
Khamraev, Vladislav
Aksenov, Nicolai A.
Kirilov, Nikita K.
Domenyuk, Dmitriy A.
Zelensky, Vladimir A.
Rubin, Michael
Publisher
Royal Society of Chemistry
Type
Article
Article Version
Scholarly/refereed, publisher version
Rights
© The Royal Society of Chemistry 2019.
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Abstract
A novel methodology for general and chemoselective preparation of non-symmetric 1,3,4-oxadiazoles is developed. This unusual reaction proceeds via polyphosphoric acid-assisted activation of nitroalkanes towards nucleophilic attack with acylhydrazides.
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
URI
http://hdl.handle.net/1808/31409
DOI
https://doi.org/10.1039/c9ra00976k
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Citation
Alexander V. Aksenov, V. Khamraev, N. A. Aksenov, N. K. Kirilov, D. A. Domenyuk, V. A. Zelensky and M. Rubin, "Electrophilic activation of nitroalkanes in efficient synthesis of 1,3,4-oxadiazoles", RSC Adv., 2019, 9, 6636, DOI: 10.1039/C9RA00976K

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© The Royal Society of Chemistry 2019.
Except where otherwise noted, this item's license is described as: © The Royal Society of Chemistry 2019.