ATTENTION: The software behind KU ScholarWorks is being upgraded to a new version. Starting July 15th, users will not be able to log in to the system, add items, nor make any changes until the new version is in place at the end of July. Searching for articles and opening files will continue to work while the system is being updated.
If you have any questions, please contact Marianne Reed at mreed@ku.edu .
Chemistry: Recent submissions
Now showing items 161-180 of 964
-
High-Definition Mapping of Four Spatially Distinct Neutralizing Epitope Clusters on RiVax, a Candidate Ricin Toxin Subunit Vaccine
(American Society for Microbiology, 2017-10-18)RiVax is a promising recombinant ricin toxin A subunit (RTA) vaccine antigen that has been shown to be safe and immunogenic in humans and effective at protecting rhesus macaques against lethal-dose aerosolized toxin exposure. ... -
High-Resolution Epitope Positioning of a Large Collection of Neutralizing and Nonneutralizing Single-Domain Antibodies on the Enzymatic and Binding Subunits of Ricin Toxin
(American Society for Microbiology, 2017-12-05)We previously produced a heavy-chain-only antibody (Ab) VH domain (VHH)-displayed phage library from two alpacas that had been immunized with ricin toxoid and nontoxic mixtures of the enzymatic ricin toxin A subunit (RTA) ... -
Removing the barrier to the calculation of activation energies: Diffusion coefficients and reorientation times in liquid water
(AIP Publishing, 2017-10-03)General approaches for directly calculating the temperature dependence of dynamical quantities from simulations at a single temperature are presented. The method is demonstrated for self-diffusion and OH reorientation in ... -
Water-anion hydrogen bonding dynamics: Ultrafast IR experiments and simulations
(AIP Publishing, 2017-06-15)Many of water’s remarkable properties arise from its tendency to form an intricate and robust hydrogen bond network. Understanding the dynamics that govern this network is fundamental to elucidating the behavior of pure ... -
Tests for, origins of, and corrections to non-Gaussian statistics. The dipole-flip model
(AIP Publishing, 2017-04-21)Linear response approximations are central to our understanding and simulations of nonequilibrium statistical mechanics. Despite the success of these approaches in predicting nonequilibrium dynamics, open questions remain. ... -
Microfluidic Digital ELISA towards Single Cell Analysis
(University of Kansas, 2017-12-31)Cell-to-cell heterogeneity predicts a multitude of functions for homeostasis and development of disease states. These minute variations can make a massive impact in understanding the main components involved in a disease ... -
Dual role of polyphosphoric acid-activated nitroalkanes in oxidative peri-annulations: efficient synthesis of 1,3,6,8-tetraazapyrenes
(Royal Society of Chemistry, 2017-06-08)A highly efficient synthetic method for expeditious and selective assembly of tetraazopyrenes (TAPy) is reported, based on the novel reaction of electrophilically activated nitroalkanes with aromatic amines. Remarkably, ... -
The preparation of pyridine dicarboxylic acids by ozone oxidation and the preparation of fluorine-containing medicinals
(University of Kansas, 1950) -
The reaction of sodium azide with ethylene sulfides, ethylenimines and trimethylene oxide
(University of Kansas, 1952) -
Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman Primates
(Elsevier, 2017-02-28)Induction of broadly neutralizing antibodies (bnAbs) that target HIV-1 envelope (Env) is a goal of HIV-1 vaccine development. A bnAb target is the Env third variable loop (V3)-glycan site. To determine whether immunization ... -
Rapid LC-MS Based High-Throughput Screening Method, Affording No False Positives or False Negatives, Identifies a New Inhibitor for Carbonic Anhydrase
(Nature Research, 2017-09-04)Developing effective high-throughput screening (HTS) methods is of paramount importance in the early stage of drug discovery. While rugged and robust assays may be easily developed for certain enzymes, HTS assays designed ... -
Neurochemical Investigation of Locally Induced Epilepsy and Subsequent Oxidative Damage Using Microdialysis Sampling
(University of Kansas, 2017-05-31)The goal of this research was to develop and understand an anesthetized, multiple-seizure rat model for local epilepsy. Local seizures are not as well understood as global seizures due to their specificity and unpredictability. ... -
Investigation of the Interactions between LOV Domains by Spectroscopic Techniques
(University of Kansas, 2017-12-31)Plants have adapted a variety of methods necessary for their survival such as stomatal opening and closing, plant growth, and photosynthesis. In order to regulate these processes, plants rely on sensing sunlight in their ... -
The synthesis of organic medicinals containing fluorine
(University of Kansas, 1950) -
The electrochemistry of elements of the aluminum family in liquid ammonia
(University of Kansas, 1951) -
Synthesis and properties of the possible isomeric mono-chlor, mono-iodo-toluenes
(University of Kansas, 1927) -
I. A new commercial synthesis of the insecticide parathion.II. Studies in the benzotriazole and 2-aminipyridine series
(University of Kansas, 1950) -
Development of an Aryloxazole Class of Hepatitis C Virus Inhibitors Targeting the Entry Stage of the Viral Replication Cycle
(American Chemical Society, 2017-06-21)Reliance on hepatitis C virus (HCV) replicon systems and protein-based screening assays has led to treatments that target HCV viral replication proteins. The model does not encompass other viral replication cycle steps ... -
High-Throughput Screening, Discovery, and Optimization to Develop a Benzofuran Class of Hepatitis C Virus Inhibitors
(American Chemical Society, 2015-09-02)Using a high-throughput, cell-based HCV luciferase reporter assay to screen a diverse small-molecule compound collection (~300 000 compounds), we identified a benzofuran compound class of HCV inhibitors. The optimization ... -
Human Copper-Dependent Amine Oxidases
(Elsevier, 2014-03-15)Copper amine oxidases (CAOs) are a class of enzymes that contain Cu2+ and a tyrosine-derived quinone cofactor, catalyze the conversion of a primary amine functional group to an aldehyde, and generate hydrogen peroxide and ...