Molecular Biosciences Dissertations and Theses: Recent submissions
Now showing items 101-120 of 270
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Role of Prolactin and Prolactin Receptor Signaling in Colorectal Tumorigenesis
(University of Kansas, 2014-08-31)Hormones are critical regulatory factors produced by the body to regulate diverse physiological activities such as energy homeostasis, growth and differentiation of a diverse array of tissues, sexual maturation and development ... -
Genetic Susceptibility to the Murine Model of Retinopathy of Prematurity: Identification of a Novel Role of Tyrosinase in Retinal Angiogenic Regulation
(University of Kansas, 2013-08-31)Retinopathy of Prematurity (ROP) is a major cause of vision loss in the pediatric population. A growing body of evidence suggests that a heritable component contributes to risk of disease development. Identification of ... -
Novel effects of ouabain in autosomal dominant polycystic kidney disease cystogenesis
(University of Kansas, 2013-08-31)Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in Pkd1 or Pkd2, genes encoding for polycystin-1 (PC-1) and polycystin-2 (PC-2), respectively. ADPKD is characterized by the progressive growth ... -
Changes in Cortical Connectivity and Gene Expression of the Rostral Forelimb Area After Ischemic Infarct in Motor Cortex in the Rat
(University of Kansas, 2013-08-31)Stroke is a large and growing problem in the United States. There are 795,000 incidences each year, and most are new incidences. Survivors are left with lasting functional deficits, and therefore stroke is one of the leading ... -
Ewing's Sarcoma EWS protein regulates skeletogenesis by modulation of SOX9
(University of Kansas, 2013-05-31)Ewing sarcoma is the second most common form of bone cancer in adolescents, characterized by the presence of an aberrant chimeric fusion gene EWS/FLI1. Wildtype EWS has been proposed to play a role in splicing and ... -
Novel roles for CD23, CTLA-4 and lipoproteins in human T cell function and differentiation
(University of Kansas, 2014-05-31)The differentiation of multipotent naïve T cells is influenced by the microenvironment. Cytokines, costimulatory proteins and other biological factors can tune this differentiation process, influencing cell fate. Controlling ... -
Mechanisms of structural plasticity in mature sensory axons: Role of BMP4 in female reproductive tract
(University of Kansas, 2013-05-31)Structural changes in sensory axons are associated with many peripheral nerve disorders. Degenerative loss or excessive sprouting of axons are hallmarks of sensory neuropathies or hyperinnervating pain syndromes respectively. ... -
Structural and Biochemical Investigations of the Heme Loading Mechanisms in Hemophores HasAp from Pseudomonas aeruginosa and HasAyp from Yersinia pestis
(University of Kansas, 2014-05-31)Under iron-limiting conditions, several Gram-negative pathogens secrete hemophore (HasA) protein that binds heme and deliver it to the outer membrane receptors in bacteria. Hemophore proteins have been structurally and ... -
Regulation of telomerase reverse transcriptase expression in Schizosaccharomyces pombe
(University of Kansas, 2013-12-31)Eukaryotic cells undergo chromosome shortening during each cell division due to the inability of DNA polymerase to replicate chromosome ends. This end replication problem is counteracted by the ribonucleoprotein telomerase, ... -
pH-Triggered Membrane Insertion of Proteins
(University of Kansas, 2015-05-31)Several classes of membrane proteins refold from their original soluble conformations in response to acidification and insert into lipid bilayers. Despite the recent advances in unraveling the molecular mechanisms of ... -
REGULATION OF ALC1'S SNF2 ATPASE: INTERPLAY BETWEEN THE SNF2 DOMAIN, THE MACRODOMAIN AND OTHER CONSERVED ELEMENTS
(University of Kansas, 2015-05-31)ALC1, also known as CHD1L, was originally identified as a gene present on a human chromosome 1q21 region amplified in ~50% of human hepatocellular carcinomas (HCC). ALC1 overexpressing cells form tumors in nude mice, and ... -
MicroRNA Sequencing of Long-Term Estrogen Deprived Breast Cancer Cells Reveals a Potential Role for miR-181a in Estrogen-Independent Growth
(University of Kansas, 2015-05-31)Breast cancer is a genetically complex disease that affects over 230,000 people in the U.S. every year. Estrogen signaling has been shown to play a large role in the development and progression of breast tumors that express ... -
Targeting the adaptability of heterogeneous aneuploidy population
(University of Kansas, 2015-05-31)Aneuploid genomes, characterized by unbalanced and diverse chromosome stoichiometry (karyotype), are associated with cancer malignancy and drug-resistance of human pathogenic fungi. My PhD projects studied three aspects ... -
An analysis of the requirement for septate junction proteins in essential morphogenetic events
(University of Kansas, 2015-08-31)Proper organismal development depends upon highly regulated cellular rearrangements and cell shape changes that are driven by intrinsic stabilizing and dynamic forces within an epithelium. These morphological processes ... -
Engineering GFP-Family Member Protiens to Achieve Novel Functions: A Class of Proteins Limited Only by the Imagination
(University of Kansas, 2015-05-31)The Green Fluorescent Protein (GFP) has single handedly revolutionized microscopy and molecular biology. A simple search for GFP in the NCBI Pubmed database yields over 29,900 unique publications as of April 2015 demonstrating ... -
Effect of urea on Bacillus coli, Bacillus typhosus, and Staphylococcus aureus
(University of Kansas, 1922) -
Protein metabolism of hemolytic streptococci
(University of Kansas, 1921) -
Studies upon epidemic paralysis among guinea pigs
(University of Kansas, 1921) -
Studies on Bacillus pyocyaneus
(University of Kansas, 1922) -
Reduce, Reuse, Recycle: The tale of two Wnts and the lone C. elegans Syndecan, SDN-1
(University of Kansas, 2015-05-31)Heparan sulfate proteoglycans (HSPGs) are cell adhesion molecules that have been shown to be involved in a myriad of different aspects of development such as embryogenesis, dorsal-ventral axon guidance and cell migration. ...