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Molecular Biosciences Scholarly Works: Recent submissions
Now showing items 61-80 of 617
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Resistance to natural and synthetic gene drive systems
(Wiley, 2020-09-24)Scientists are rapidly developing synthetic gene drive elements intended for release into natural populations. These are intended to control or eradicate disease vectors and pests, or to spread useful traits through wild ... -
PICH regulates the abundance and localization of SUMOylated proteins on mitotic chromosomes
(American Society for Cell Biology, 2020-10-29)Proper chromosome segregation is essential for faithful cell division and if not maintained results in defective cell function caused by the abnormal distribution of genetic information. Polo-like kinase 1–interacting ... -
Chromosomal localization of Ewing sarcoma EWSR1/FLI1 protein promotes the induction of aneuploidy
(Elsevier, 2020-12-10)Ewing sarcoma is a pediatric bone cancer that expresses the chimeric protein EWSR1/FLI1. We previously demonstrated that EWSR1/FLI1 impairs the localization of Aurora B kinase to the midzone (the midline structure located ... -
The Collagens DPY-17 and SQT-3 Direct Anterior–Posterior Migration of the Q Neuroblasts in C. elegans
(MDPI, 2021-02-19)Cell adhesion molecules and their extracellular ligands control morphogenetic events such as directed cell migration. The migration of neuroblasts and neural crest cells establishes the structure of the central and peripheral ... -
Expanding the Junction: New Insights into Non-Occluding Roles for Septate Junction Proteins during Development
(MDPI, 2021-03-21)The septate junction (SJ) provides an occluding function for epithelial tissues in invertebrate organisms. This ability to seal the paracellular route between cells allows internal tissues to create unique compartments for ... -
Constitutive Musashi1 expression impairs mouse postnatal development and intestinal homeostasis
(American Society for Cell Biology, 2020-12-29)Evolutionarily conserved RNA-binding protein Musashi1 (Msi1) can regulate developmentally relevant genes. Here we report the generation and characterization of a mouse model that allows inducible Msi1 overexpression in a ... -
HPF1-dependent PARP activation promotes LIG3-XRCC1-mediated backup pathway of Okazaki fragment ligation
(Oxford University Press, 2021-04-19)DNA ligase 1 (LIG1) is known as the major DNA ligase responsible for Okazaki fragment joining. Recent studies have implicated LIG3 complexed with XRCC1 as an alternative player in Okazaki fragment joining in cases where ... -
Characterizing the genetic basis of copper toxicity in Drosophila reveals a complex pattern of allelic, regulatory, and behavioral variation
(Oxford University Press, 2020-12-10)A range of heavy metals are required for normal cell function and homeostasis. However, the anthropogenic release of metal compounds into soil and water sources presents a pervasive health threat. Copper is one of many ... -
The Diversity and Evolution of Sex Chromosomes in Frogs
(MDPI, 2021-03-26)Frogs are ideal organisms for studying sex chromosome evolution because of their diversity in sex chromosome differentiation and sex-determination systems. We review 222 anuran frogs, spanning ~220 Myr of divergence, with ... -
Inhibition of RNA-binding protein HuR reduces glomerulosclerosis in experimental nephritis
(Portland Press, 2020-06-18)Recent identification of an RNA-binding protein (HuR) that regulates mRNA turnover and translation of numerous transcripts via binding to an ARE in their 3′-UTR involved in inflammation and is abnormally elevated in varied ... -
Fungally Derived Isoquinoline Demonstrates Inducer-Specific Tau Aggregation Inhibition
(American Chemical Society, 2021-05-19)The microtubule-associated protein tau promotes the stabilization of the axonal cytoskeleton in neurons. In several neurodegenerative diseases, such as Alzheimer’s disease, tau has been found to dissociate from microtubules, ... -
Influence of the Alternative Sigma Factor RpoN on Global Gene Expression and Carbon Catabolism in Enterococcus faecalis V583
(American Society for Microbiology, 2021-05-18)The alternative sigma factor σ54 has been shown to regulate the expression of a wide array of virulence-associated genes, as well as central metabolism, in bacterial pathogens. In Gram-positive organisms, the σ54 is commonly ... -
N-Terminomics Strategies for Protease Substrates Profiling
(MDPI, 2021-08-03)Proteases play a central role in various biochemical pathways catalyzing and regulating key biological events. Proteases catalyze an irreversible post-translational modification called proteolysis by hydrolyzing peptide ... -
Specific Engineered G Protein Coupling to Histamine Receptors Revealed from Cellular Assay Experiments and Accelerated Molecular Dynamics Simulations
(MDPI, 2021-09-17)G protein-coupled receptors (GPCRs) are targets of extracellular stimuli and hence occupy a key position in drug discovery. By specific and not yet fully elucidated coupling profiles with α subunits of distinct G protein ... -
Overexpression of a three-gene conidial pigment biosynthetic pathway in Aspergillus nidulans reveals the first NRPS known to acetylate tryptophan
(Elsevier, 2017-01-17)Fungal nonribosomal peptide synthetases (NRPSs) are megasynthetases that produce cyclic and acyclic peptides. In Aspergillus nidulans, the NRPS ivoA (AN10576) has been associated with the biosynthesis of grey-brown ... -
Gaussian accelerated molecular dynamics for elucidation of drug pathways
(Taylor & Francis, 2018-10-29)Introduction: Understanding pathways and mechanisms of drug binding to receptors is important for rational drug design. Remarkable advances in supercomputing and methodological developments have opened a new era for ... -
Resistance Gene-Guided Genome Mining: Serial Promoter Exchanges in Aspergillus nidulans Reveal the Biosynthetic Pathway for Fellutamide B, a Proteasome Inhibitor
(American Chemical Society, 2016-06-13)Fungal genome projects are revealing thousands of cryptic secondary metabolism (SM) biosynthetic gene clusters that encode pathways that potentially produce valuable compounds. Heterologous expression systems should allow ... -
Acceleration of biomolecular kinetics in Gaussian accelerated molecular dynamics
(AIP Publishing, 2018-08-21)Recent studies demonstrated that Gaussian accelerated molecular dynamics (GaMD) is a robust computational technique, which provides simultaneous unconstrained enhanced sampling and free energy calculations of biomolecules. ... -
The phage gene wmk is a candidate for male killing by a bacterial endosymbiont
(Public Library of Science, 2019-09-10)Wolbachia are the most widespread maternally-transmitted bacteria in the animal kingdom. Their global spread in arthropods and varied impacts on animal physiology, evolution, and vector control are in part due to parasitic ... -
MERS-CoV 4b protein interferes with the NF-κB-dependent innate immune response during infection
(Public Library of Science, 2018-01-25)Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel human coronavirus that emerged in 2012, causing severe pneumonia and acute respiratory distress syndrome (ARDS), with a case fatality rate of ~36%. When ...