Molecular Biosciences Scholarly Works: Recent submissions
Now showing items 41-60 of 606
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Positive Selection and Horizontal Gene Transfer in the Genome of a Male-Killing Wolbachia
(Oxford University Press, 2021-10-18)Wolbachia are a genus of widespread bacterial endosymbionts in which some strains can hijack or manipulate arthropod host reproduction. Male killing is one such manipulation in which these maternally transmitted bacteria ... -
The Conserved Macrodomain Is a Potential Therapeutic Target for Coronaviruses and Alphaviruses
(MDPI, 2022-01-14)Emerging and re-emerging viral diseases pose continuous public health threats, and effective control requires a combination of non-pharmacologic interventions, treatment with antivirals, and prevention with vaccines. The ... -
The Immunoglobulin Superfamily Members syg-2 and syg-1 Regulate Neurite Development in C. elegans
(MDPI, 2022-01-09)Neurons form elaborate networks by guiding axons and dendrites to appropriate destinations. Neurites require information about the relative body axes during the initial projection from the cell body, and failure to receive ... -
Rapid divergence of the male reproductive proteins in the Drosophila dunni group and implications for postmating incompatibilities between species
(Oxford University Press, 2021-02-18)Proteins involved in post-copulatory interactions between males and females are among the fastest evolving genes in many species, usually attributed to their involvement in reproductive conflict. As a result, these proteins ... -
A single synonymous nucleotide change impacts the male-killing phenotype of prophage WO gene wmk
(eLife Sciences Publications, 2021-10-22)Wolbachia are the most widespread bacterial endosymbionts in animals. Within arthropods, these maternally transmitted bacteria can selfishly hijack host reproductive processes to increase the relative fitness of their ... -
The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression
(Public Library of Science, 2019-05-16)ADP-ribosylation is a ubiquitous post-translational addition of either monomers or polymers of ADP-ribose to target proteins by ADP-ribosyltransferases, usually by interferon-inducible diphtheria toxin-like enzymes known ... -
Mitochondrial DNA Manipulations Affect Tau Oligomerization
(IOS Press, 2020-06-02)Background:Mitochondrial dysfunction and tau aggregation occur in Alzheimer’s disease (AD), and exposing cells or rodents to mitochondrial toxins alters their tau. Objective:To further explore how mitochondria influence ... -
Inhibition of RNA-binding protein HuR reduces glomerulosclerosis in experimental nephritis
(Portland Press, 2020-06-18)Recent identification of an RNA-binding protein (HuR) that regulates mRNA turnover and translation of numerous transcripts via binding to an ARE in their 3′-UTR involved in inflammation and is abnormally elevated in varied ... -
The Chemistry and Biology of Bactobolin: A 10-Year Collaboration with Natural Product Chemist Extraordinaire Jon Clardy
(American Chemical Society, 2020-02-27)Bactobolin is a hybrid natural product with potent cytotoxic activity. Its production from Burkholderia thailandensis was reported as part of a collaboration between the Greenberg and Clardy laboratories in 2010. The ... -
Resistance to natural and synthetic gene drive systems
(Wiley, 2020-09-24)Scientists are rapidly developing synthetic gene drive elements intended for release into natural populations. These are intended to control or eradicate disease vectors and pests, or to spread useful traits through wild ... -
PICH regulates the abundance and localization of SUMOylated proteins on mitotic chromosomes
(American Society for Cell Biology, 2020-10-29)Proper chromosome segregation is essential for faithful cell division and if not maintained results in defective cell function caused by the abnormal distribution of genetic information. Polo-like kinase 1–interacting ... -
Chromosomal localization of Ewing sarcoma EWSR1/FLI1 protein promotes the induction of aneuploidy
(Elsevier, 2020-12-10)Ewing sarcoma is a pediatric bone cancer that expresses the chimeric protein EWSR1/FLI1. We previously demonstrated that EWSR1/FLI1 impairs the localization of Aurora B kinase to the midzone (the midline structure located ... -
The Collagens DPY-17 and SQT-3 Direct Anterior–Posterior Migration of the Q Neuroblasts in C. elegans
(MDPI, 2021-02-19)Cell adhesion molecules and their extracellular ligands control morphogenetic events such as directed cell migration. The migration of neuroblasts and neural crest cells establishes the structure of the central and peripheral ... -
Expanding the Junction: New Insights into Non-Occluding Roles for Septate Junction Proteins during Development
(MDPI, 2021-03-21)The septate junction (SJ) provides an occluding function for epithelial tissues in invertebrate organisms. This ability to seal the paracellular route between cells allows internal tissues to create unique compartments for ... -
Constitutive Musashi1 expression impairs mouse postnatal development and intestinal homeostasis
(American Society for Cell Biology, 2020-12-29)Evolutionarily conserved RNA-binding protein Musashi1 (Msi1) can regulate developmentally relevant genes. Here we report the generation and characterization of a mouse model that allows inducible Msi1 overexpression in a ... -
HPF1-dependent PARP activation promotes LIG3-XRCC1-mediated backup pathway of Okazaki fragment ligation
(Oxford University Press, 2021-04-19)DNA ligase 1 (LIG1) is known as the major DNA ligase responsible for Okazaki fragment joining. Recent studies have implicated LIG3 complexed with XRCC1 as an alternative player in Okazaki fragment joining in cases where ... -
Characterizing the genetic basis of copper toxicity in Drosophila reveals a complex pattern of allelic, regulatory, and behavioral variation
(Oxford University Press, 2020-12-10)A range of heavy metals are required for normal cell function and homeostasis. However, the anthropogenic release of metal compounds into soil and water sources presents a pervasive health threat. Copper is one of many ... -
The Diversity and Evolution of Sex Chromosomes in Frogs
(MDPI, 2021-03-26)Frogs are ideal organisms for studying sex chromosome evolution because of their diversity in sex chromosome differentiation and sex-determination systems. We review 222 anuran frogs, spanning ~220 Myr of divergence, with ... -
Inhibition of RNA-binding protein HuR reduces glomerulosclerosis in experimental nephritis
(Portland Press, 2020-06-18)Recent identification of an RNA-binding protein (HuR) that regulates mRNA turnover and translation of numerous transcripts via binding to an ARE in their 3′-UTR involved in inflammation and is abnormally elevated in varied ... -
Fungally Derived Isoquinoline Demonstrates Inducer-Specific Tau Aggregation Inhibition
(American Chemical Society, 2021-05-19)The microtubule-associated protein tau promotes the stabilization of the axonal cytoskeleton in neurons. In several neurodegenerative diseases, such as Alzheimer’s disease, tau has been found to dissociate from microtubules, ...