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CRC-derived exosomes containing the RNA binding protein HuR promote lung cell proliferation by stabilizing c-Myc mRNA
(Taylor and Francis, 2022-02-07)HuR overexpression is related to poor survival in patients with colon cancer. HuR overexpression leads to stabilization of tumor-promoting mRNAs by binding to 3′UTR-resident AREs. Exosomes, nanosized lipid bilayer vesicles, ... -
Pseudomonas aeruginosa Bacterioferritin Is Assembled from FtnA and BfrB Subunits with the Relative Proportions Dependent on the Environmental Oxygen Availability
(MDPI, 2022-02-25)Ferritins are iron storage proteins assembled from 24 subunits into a spherical and hollow structure. The genomes of many bacteria harbor genes encoding two types of ferritin-like proteins, the bacterial ferritins (Ftn) ... -
Wild-type Caenorhabditis elegans isolates exhibit distinct gene expression profiles in response to microbial infection
(BMC, 2022-03-23)The soil-dwelling nematode Caenorhabditis elegans serves as a model system to study innate immunity against microbial pathogens. C. elegans have been collected from around the world, where they, presumably, adapted to ... -
Mechanism of Peptide Agonist Binding in CXCR4 Chemokine Receptor
(Frontiers Media, 2022-03-11)Chemokine receptors are key G-protein-coupled receptors (GPCRs) that control cell migration in immune system responses, development of cardiovascular and central nervous systems, and numerous diseases. In particular, the ... -
The 15-aa repeat region of Adenomatous polyposis coli is intrinsically disordered and retains conformational flexibility upon binding β-catenin
(American Chemical Society, 2020-10-20)The tumor suppressor Adenomatous polyposis coli (APC) is a large, multidomain protein with many identified cellular functions. The best characterized role of APC is to scaffold a protein complex that negatively regulates ... -
Caenorhabditis elegans ETR-1/CELF has broad effects on the muscle cell transcriptome, including genes that regulate translation and neuroblast migration
(BMC, 2022-01-06)Migration of neuroblasts and neurons from their birthplace is central to the formation of neural circuits and networks. ETR-1 is the Caenorhabditis elegans homolog of the CELF1 (CUGBP, ELAV-like family 1) RNA-processing ... -
Positive Selection and Horizontal Gene Transfer in the Genome of a Male-Killing Wolbachia
(Oxford University Press, 2021-10-18)Wolbachia are a genus of widespread bacterial endosymbionts in which some strains can hijack or manipulate arthropod host reproduction. Male killing is one such manipulation in which these maternally transmitted bacteria ... -
The Conserved Macrodomain Is a Potential Therapeutic Target for Coronaviruses and Alphaviruses
(MDPI, 2022-01-14)Emerging and re-emerging viral diseases pose continuous public health threats, and effective control requires a combination of non-pharmacologic interventions, treatment with antivirals, and prevention with vaccines. The ... -
The Immunoglobulin Superfamily Members syg-2 and syg-1 Regulate Neurite Development in C. elegans
(MDPI, 2022-01-09)Neurons form elaborate networks by guiding axons and dendrites to appropriate destinations. Neurites require information about the relative body axes during the initial projection from the cell body, and failure to receive ... -
Rapid divergence of the male reproductive proteins in the Drosophila dunni group and implications for postmating incompatibilities between species
(Oxford University Press, 2021-02-18)Proteins involved in post-copulatory interactions between males and females are among the fastest evolving genes in many species, usually attributed to their involvement in reproductive conflict. As a result, these proteins ... -
A single synonymous nucleotide change impacts the male-killing phenotype of prophage WO gene wmk
(eLife Sciences Publications, 2021-10-22)Wolbachia are the most widespread bacterial endosymbionts in animals. Within arthropods, these maternally transmitted bacteria can selfishly hijack host reproductive processes to increase the relative fitness of their ... -
The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression
(Public Library of Science, 2019-05-16)ADP-ribosylation is a ubiquitous post-translational addition of either monomers or polymers of ADP-ribose to target proteins by ADP-ribosyltransferases, usually by interferon-inducible diphtheria toxin-like enzymes known ... -
Mitochondrial DNA Manipulations Affect Tau Oligomerization
(IOS Press, 2020-06-02)Background:Mitochondrial dysfunction and tau aggregation occur in Alzheimer’s disease (AD), and exposing cells or rodents to mitochondrial toxins alters their tau. Objective:To further explore how mitochondria influence ... -
Inhibition of RNA-binding protein HuR reduces glomerulosclerosis in experimental nephritis
(Portland Press, 2020-06-18)Recent identification of an RNA-binding protein (HuR) that regulates mRNA turnover and translation of numerous transcripts via binding to an ARE in their 3′-UTR involved in inflammation and is abnormally elevated in varied ... -
The Chemistry and Biology of Bactobolin: A 10-Year Collaboration with Natural Product Chemist Extraordinaire Jon Clardy
(American Chemical Society, 2020-02-27)Bactobolin is a hybrid natural product with potent cytotoxic activity. Its production from Burkholderia thailandensis was reported as part of a collaboration between the Greenberg and Clardy laboratories in 2010. The ... -
Resistance to natural and synthetic gene drive systems
(Wiley, 2020-09-24)Scientists are rapidly developing synthetic gene drive elements intended for release into natural populations. These are intended to control or eradicate disease vectors and pests, or to spread useful traits through wild ... -
PICH regulates the abundance and localization of SUMOylated proteins on mitotic chromosomes
(American Society for Cell Biology, 2020-10-29)Proper chromosome segregation is essential for faithful cell division and if not maintained results in defective cell function caused by the abnormal distribution of genetic information. Polo-like kinase 1–interacting ... -
Chromosomal localization of Ewing sarcoma EWSR1/FLI1 protein promotes the induction of aneuploidy
(Elsevier, 2020-12-10)Ewing sarcoma is a pediatric bone cancer that expresses the chimeric protein EWSR1/FLI1. We previously demonstrated that EWSR1/FLI1 impairs the localization of Aurora B kinase to the midzone (the midline structure located ... -
The Collagens DPY-17 and SQT-3 Direct Anterior–Posterior Migration of the Q Neuroblasts in C. elegans
(MDPI, 2021-02-19)Cell adhesion molecules and their extracellular ligands control morphogenetic events such as directed cell migration. The migration of neuroblasts and neural crest cells establishes the structure of the central and peripheral ... -
Expanding the Junction: New Insights into Non-Occluding Roles for Septate Junction Proteins during Development
(MDPI, 2021-03-21)The septate junction (SJ) provides an occluding function for epithelial tissues in invertebrate organisms. This ability to seal the paracellular route between cells allows internal tissues to create unique compartments for ...
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