Molecular Biosciences Scholarly Works
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Non-Catalytic Roles of the Topoisomerase IIα C-Terminal Domain
(MDPI, 2017)DNA Topoisomerase II (Topo II ) is a ubiquitous enzyme in eukaryotes that performs the strand passage reaction where a double helix of DNA is passed through a second double helix. This unique reaction is critical for ... -
Identification of a new small ubiquitin-like modifier (SUMO)-interacting motif in the E3 ligase PIASy
(American Society for Biochemistry and Molecular Biology, 2017)Small ubiquitin-like modifier (SUMO) conjugation is a reversible post-translational modification process implicated in the regulation of gene transcription, DNA repair, and cell cycle. SUMOylation depends on the sequential ... -
Draft Genome Sequence of Lysinibacillus fusiformis Strain Juneja, a Laboratory-Derived Pathogen of Drosophila melanogaster
(American Society for Microbiology, 2018-02-01)Drosophila melanogaster is a model for the study of innate immunity, yet we have limited knowledge of its natural pathogens. In this study, we sequenced the genome of Lysinibacillus fusiformis strain Juneja, isolated from ... -
MTBP inhibits the Erk1/2-Elk-1 signaling in hepatocellular carcinoma
(Impact Journals, 2018-04-20)Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, and the prognosis of HCC patients, especially those with metastasis, remains extremely poor. This is partly due to unclear molecular mechanisms ... -
Bacterial Quorum Sensing and Microbial Community Interactions
(American Society for Microbiology, 2018-05-22)Many bacteria use a cell-cell communication system called quorum sensing to coordinate population density-dependent changes in behavior. Quorum sensing involves production of and response to diffusible or secreted signals, ... -
Transmission Dynamics of Bovine Anaplasmosis in a Cattle Herd
(Hindawi Publishing Corporation, 2018-05-02)Bovine anaplasmosis is an infectious disease of cattle caused by the obligate intercellular bacterium, Anaplasma marginale, and it primarily occurs in tropical and subtropical regions of the world. In this study, an ... -
Ligand Binding Pathways and Conformational Transitions of the HIV Protease
(Biochemistry, 2018-03-06)It is important to determine the binding pathways and mechanisms of ligand molecules to target proteins to effectively design therapeutic drugs. Molecular dynamics (MD) is a promising computational tool that allows us to ... -
Characterization of Small Molecule Scaffolds that Bind to the Shigella Type III Secretion System Protein IpaD
(Wiley, 2017-09-21)Many pathogens such as Shigella and other bacteria assemble the type III secretion system (T3SS) nanoinjector to inject virulence proteins into their target cells to cause infectious diseases in humans. The rise of drug ... -
Template-Based Modeling of Protein-RNA Interactions
(Public Library of Science, 201-09-23)Protein-RNA complexes formed by specific recognition between RNA and RNA-binding proteins play an important role in biological processes. More than a thousand of such proteins in human are curated and many novel RNA-binding ... -
EGL-20/Wnt and MAB-5/Hox Act Sequentially to Inhibit Anterior Migration of Neuroblasts in C. elegans
(Public Library of Science, 2016-02-10)Directed neuroblast and neuronal migration is important in the proper development of nervous systems. In C. elegans the bilateral Q neuroblasts QR (on the right) and QL (on the left) undergo an identical pattern of cell ... -
Cellular Growth Arrest and Persistence from Enzyme Saturation
(Public Library of Science, 2016-03-24)Metabolic efficiency depends on the balance between supply and demand of metabolites, which is sensitive to environmental and physiological fluctuations, or noise, causing shortages or surpluses in the metabolic pipeline. ... -
Annual Greenland accumulation rates (2009–2012) from airborne snow radar
(European Geosciences Union, 2016-08-11)Contemporary climate warming over the Arctic is accelerating mass loss from the Greenland Ice Sheet through increasing surface melt, emphasizing the need to closely monitor its surface mass balance in order to improve ... -
Mapping QTL Contributing to Variation in Posterior Lobe Morphology between Strains of Drosophila melanogaster
(PLoS, 2016-09-08)Closely-related, and otherwise morphologically similar insect species frequently show striking divergence in the shape and/or size of male genital structures, a phenomenon thought to be driven by sexual selection. Comparative ... -
Genetic analysis of variation in lifespan using a multiparental advanced intercross Drosophila mapping population
(BioMed Central, 2016-08-02)Background: Considerable natural variation for lifespan exists within human and animal populations. Genetically dissecting this variation can elucidate the pathways and genes involved in aging, and help uncover the genetic ... -
Quorum Sensing Influences Burkholderia thailandensis Biofilm Development and Matrix Production
(American Society for Microbiology, 2016-04-11)Members of the genus Burkholderia are known to be adept at biofilm formation, which presumably assists in the survival of these organisms in the environment and the host. Biofilm formation has been linked to quorum sensing ... -
Draft Genome Sequence of Chromobacterium violaceum Strain CV017
(American Society for Microbiology, 2016-03-03)We announce the draft genome sequence for Chromobacterium violaceum strain CV017, used as a model and tool to understand acyl-homoserine lactone-dependent quorum sensing. The assembly consists of 4,774,638-bp contained in ... -
Gemcitabine enhances cell invasion via activating HAb18G/CD147-EGFR-pSTAT3 signaling
(Impact Journals, 2016-08-19)Pancreatic cancer, one of the most lethal cancers, has very poor 5-year survival partly due to gemcitabine resistance. Recently, it was reported that chemotherapeutic agents may act as stressors to induce adaptive responses ... -
Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis
(Impact Journals, 2016-09-22)Colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer-related mortality. Observed during CRC tumorigenesis is loss of post-transcriptional regulation of tumor-promoting genes such as COX-2, ... -
Overcoming chemo/radio-resistance of pancreatic cancer by inhibiting STAT3 signaling
(Impact Journals, 2016-02-12)Chemo/radio-therapy resistance to the deadly pancreatic cancer is mainly due to the failure to kill pancreatic cancer stem cells (CSCs). Signal transducer and activator of transcription 3 (STAT3) is activated in pancreatic ... -
SUMOylation of DNA topoisomerase IIα regulates histone H3 kinase Haspin and H3 phosphorylation in mitosis
(Rockefeller University Press, 2016-06-20)DNA topoisomerase II (TOP2) plays a pivotal role in faithful chromosome separation through its strand-passaging activity that resolves tangled genomic DNA during mitosis. Additionally, TOP2 controls progression of mitosis ...
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