Molecular Biosciences Scholarly Works
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Gemcitabine enhances cell invasion via activating HAb18G/CD147-EGFR-pSTAT3 signaling
(Impact Journals, 2016-08-19)Pancreatic cancer, one of the most lethal cancers, has very poor 5-year survival partly due to gemcitabine resistance. Recently, it was reported that chemotherapeutic agents may act as stressors to induce adaptive responses ... -
Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis
(Impact Journals, 2016-09-22)Colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer-related mortality. Observed during CRC tumorigenesis is loss of post-transcriptional regulation of tumor-promoting genes such as COX-2, ... -
Overcoming chemo/radio-resistance of pancreatic cancer by inhibiting STAT3 signaling
(Impact Journals, 2016-02-12)Chemo/radio-therapy resistance to the deadly pancreatic cancer is mainly due to the failure to kill pancreatic cancer stem cells (CSCs). Signal transducer and activator of transcription 3 (STAT3) is activated in pancreatic ... -
SUMOylation of DNA topoisomerase IIα regulates histone H3 kinase Haspin and H3 phosphorylation in mitosis
(Rockefeller University Press, 2016-06-20)DNA topoisomerase II (TOP2) plays a pivotal role in faithful chromosome separation through its strand-passaging activity that resolves tangled genomic DNA during mitosis. Additionally, TOP2 controls progression of mitosis ... -
Natural product (L)-gossypol inhibits colon cancer cell growth by targeting RNA-binding protein Musashi-1
(Wiley Open Access, 2015-04-10)Musashi-1 (MSI1) is an RNA-binding protein that acts as a translation activator or repressor of target mRNAs. The best-characterized MSI1 target is Numb mRNA, whose encoded protein negatively regulates Notch signaling. ... -
Overexpression of the Aspergillus nidulans histone 4 acetyltransferase EsaA increases activation of secondary metabolite production
(Wiley, 2012-10)Regulation of secondary metabolite (SM) gene clusters in Aspergillus nidulans has been shown to occur through cluster specific transcription factors or through global regulators of chromatin structure such as histone ... -
Chlamydia trachomatis protein CT009 is a structural and functional homolog to the key morphogenesis component RodZ and interacts with division septal plane localized MreB
(Wiley, 2015-02)Cell division in Chlamydiae is poorly understood as apparent homologs to most conserved bacterial cell division proteins are lacking and presence of elongation (rod shape) associated proteins indicate non-canonical mechanisms ... -
A de novo protein binding pair by computational design and directed evolution
(Elsevier, 2011-04-22)The de novo design of protein-protein interfaces is a stringent test of our understanding of the principles underlying protein-protein interactions and would enable new approaches to biological and medical challenges. Here ... -
Molecular genetic analysis of the orsellinic acid/F9775 gene cluster of Aspergillus nidulans†,‡
(Royal Society of Chemistry, 2010-03)F-9775A and F-9775B are cathepsin K inhibitors that arise from a chromatin remodelling deletant strain of Aspergillus nidulans. A polyketide synthase gene has been determined to be responsible for their formation and for ... -
Identification and molecular genetic analysis of the cichorine gene cluster in Aspergillus nidulans
(Royal Society of Chemistry, 2012-08-01)We recently demonstrated that the phytotoxin cichorine is produced by Aspergillus nidulans. Through a set of targeted deletions, we have found a cluster of seven genes that are required for its biosynthesis. Two of the ... -
Sec61á is required for dorsal closure during Drosophila embryogenesis through its regulation of Dpp signaling
(Wiley, 2010-03)During dorsal closure in Drosophila, signaling events in the dorsalmost row of epidermal cells (DME cells) direct the migration of lateral epidermal sheets towards the dorsal midline where they fuse to enclose the embryo. ... -
A Flow Cytometric Assay for the Study of E3 Ubiquitin Ligase Activityb
(Wiley, 2009-07)BACKGROUND: Current methods for monitoring E3 ubiquitin ligase activity in cell culture or in vivo are limited. As a result, the degradation of cellular targets by many E3 ubiquitin ligases in live cells has not yet been ... -
Loss of dystrophin and the microtubule-binding protein ELP-1 causes progressive paralysis and death of adult C. elegans
(Wiley, 2009-08)EMAP-like proteins (ELPs) are conserved microtubule-binding proteins that function during cell division and in the behavior of post-mitotic cells. In C. elegans, ELP-1 is broadly expressed in many cells and tissues including ... -
Protein Structure Prediction: Is It Useful?
(Elsevier, 2009-04)Computationally predicted three-dimensional structure of protein molecules has demonstrated the usefulness in many areas of biomedicine, ranging from approximate family assignments to precise drug screening. For nearly 40 ... -
Low-resolution structural modeling of protein interactome
(Elsevier, 2013-04)Structural characterization of protein–protein interactions across the broad spectrum of scales is key to our understanding of life at the molecular level. Low-resolution approach to protein interactions is needed for ... -
Computational Design of Affinity and Specificity at Protein-Protein Interfaces
(Elsevier, 2009-08)The computer-based design of protein-protein interactions is a rigorous test of our understanding of molecular recognition and an attractive approach for creating novel tools for cell and molecular research. Considerable ... -
Elimination of T cell reactivity to pancreatic β cells and partial preservation of β cell activity by peptide blockade of LFA-1:ICAM-1 interaction in the NOD mouse model
(Elsevier, 2013-08)In insulin dependent diabetes mellitus (T1D), self-reactive T cells infiltrate pancreatic islets and induce beta cell destruction and dysregulation of blood glucose. A goal is to control only the self-reactive T cells, ... -
The designability of protein switches by chemical rescue of structure: mechanisms of inactivation and reactivation
(American Chemical Society, 2013-12-18)The ability to selectively activate function of particular proteins via pharmacological agents is a longstanding goal in chemical biology. Recently, we reported an approach for designing a de novo allosteric effector site ... -
Novel Pyrrolopyrimidine-Based α-Helix Mimetics: Cell- Permeable Inhibitors of Protein-Protein Interactions
(American Chemical Society, 2011-02-02)There is considerable interest in developing nonpeptidic, small molecule α-helix mimetics to disrupt α-helix-mediated protein-protein interactions. Herein, we report the design of a novel pyrrolopyrimidine-based scaffold ... -
Illuminating the diversity of aromantic polyketide synthases in Aspergillus nidulans
(American Chemical Society, 2012-05-16)Genome sequencing has revealed that fungi have the ability to synthesize many more natural products (NPs) than are currently known, but methods for obtaining suitable expression of NPs have been inadequate. We have developed ...
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