Molecular Biosciences Scholarly Works
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Use of gene sequences as type for naming prokaryotes: Recommendations of the international committee on the taxonomy of chlamydiae
(Elsevier, 2023-09)The International Committee on Systematics of Prokaryotes (ICSP) discussed and rejected in 2020 a proposal to modify the International Code of Nomenclature of Prokaryotes to allow the use of gene sequences as type for ... -
Repurposing Niclosamide as a Novel Anti-SARS-CoV-2 Drug by Restricting Entry Protein CD147
(MDPI, 2023-07-18)The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to the global coronavirus disease 2019 (COVID-19) pandemic, and the search for effective treatments has been limited. Furthermore, the ... -
Targeting RNA-binding protein HuR to inhibit the progression of renal tubular fibrosis
(BMC, 2023-06-30)Background Upregulation of an RNA-binding protein HuR has been implicated in glomerular diseases. Herein, we evaluated whether it is involved in renal tubular fibrosis. Methods HuR was firstly examined in human kidney ... -
Protein folds vs. protein folding: Differing questions, different challenges
(National Academy of Sciences, 2022-12-29) -
Herpes Simplex Virus 1 (HSV-1) Infected Cell Protein 0 (ICP0) Targets of Ubiquitination during Productive Infection of Primary Adult Sensory Neurons
(MDPI, 2023-02-02)Herpes simplex virus 1 (HSV-1) enters sensory neurons with the potential for productive or latent infection. For either outcome, HSV-1 must curtail the intrinsic immune response, regulate viral gene expression, and remove ... -
Methylated histones on mitotic chromosomes promote topoisomerase IIα function for high fidelity chromosome segregation
(Cell Press, 2023-05-19)DNA Topoisomerase IIα (TopoIIα) decatenates sister chromatids, allowing their segregation in mitosis. Without the TopoIIα Strand Passage Reaction (SPR), chromosome bridges and ultra-fine DNA bridges (UFBs) arise in anaphase. ... -
Genetic variation in chromatin state across multiple tissues in Drosophila melanogaster
(Public Library of Science, 2023-05-05)We use ATAC-seq to examine chromatin accessibility for four different tissues in Drosophila melanogaster: adult female brain, ovaries, and both wing and eye-antennal imaginal discs from males. Each tissue is assayed in ... -
Cross-species activation of hydrogen cyanide production by a promiscuous quorum-sensing receptor promotes Chromobacterium subtsugae competition in a dual-species model
(Microbiology Society, 2023-02-15)Many saprophytic bacteria have LuxR-I-type acyl-homoserine lactone (AHL) quorum-sensing systems that may be important for competing with other bacteria in complex soil communities. LuxR AHL receptors specifically interact ... -
Conversion of Polyethylenes into Fungal Secondary Metabolites
(Wiley, 2022-11-03)Waste plastics represent major environmental and economic burdens due to their ubiquity, slow breakdown rates, and inadequacy of current recycling routes. Polyethylenes are particularly problematic, because they lack robust ... -
The genetic basis of adaptation to copper pollution in Drosophila melanogaster
(Frontiers Media, 2023-04-04)Introduction: Heavy metal pollutants can have long lasting negative impacts on ecosystem health and can shape the evolution of species. The persistent and ubiquitous nature of heavy metal pollution provides an opportunity ... -
TOM-1/tomosyn acts with the UNC-6/netrin receptor UNC-5 to inhibit growth cone protrusion in Caenorhabditis elegans
(The Company of Biologists, 2023-04-04)In the polarity/protrusion model of growth cone repulsion from UNC-6/netrin, UNC-6 first polarizes the growth cone of the VD motor neuron axon via the UNC-5 receptor, and then regulates protrusion asymmetrically across the ... -
The reporting quality and transparency of orthopaedic studies using Bayesian analysis requires improvement: A systematic review
(Elsevier, 2023-04-07)Background Bayesian methods are being used more frequently in orthopaedics. To advance the use and transparent reporting of Bayesian studies, reporting guidelines have been recommended. There is currently little known ... -
Inhibitors of One or More Cellular Aurora Kinases Impair the Replication of Herpes Simplex Virus 1 and Other DNA and RNA Viruses with Diverse Genomes and Life Cycles
(American Society for Microbiology, 2022-12-20)We utilized a high-throughput cell-based assay to screen several chemical libraries for inhibitors of herpes simplex virus 1 (HSV-1) gene expression. From this screen, four aurora kinase inhibitors were identified that ... -
EWSR1 prevents the induction of aneuploidy through direct regulation of Aurora B
(Frontiers Media, 2023-02-15)EWSR1 (Ewing sarcoma breakpoint region 1) was originally identified as a part of an aberrant EWSR1/FLI1 fusion gene in Ewing sarcoma, the second most common pediatric bone cancer. Due to formation of the EWSR1/FLI1 fusion ... -
Sustainable Methodologies for Efficient Gel Electrophoresis and Streamlined Screening of Difficult Plasmids
(MDPI, 2023-03-06)We describe a workflow for efficient, environmentally attentive, and sustainable practices related to routine agarose gel electrophoresis. The methods reduce plastic waste and improve efficiency, especially for the exhaustive ... -
Sustainable and Cost-Effective Gel Documentation
(MDPI, 2023-02-21)A common laboratory method involves gel electrophoresis followed by photographic documentation of the results, a procedure which is performed worldwide by students and experienced scientists alike. Proprietary Gel Documentation ... -
Branched actin networks are assembled on microtubules by adenomatous polyposis coli for targeted membrane protrusion
(Rockefeller University Press, 2020-06-29)Cell migration is driven by pushing and pulling activities of the actin cytoskeleton, but migration directionality is largely controlled by microtubules. This function of microtubules is especially critical for neuron ... -
Editorial: Mechanisms, thermodynamics and kinetics of ligand binding revealed from molecular simulations and machine learning
(Frontiers Media, 2023-01-17) -
GLOW: A Workflow Integrating Gaussian-Accelerated Molecular Dynamics and Deep Learning for Free Energy Profiling
(American Chemical Society, 2022-02-24)We introduce a Gaussian-accelerated molecular dynamics (GaMD), deep learning (DL), and free energy profiling workflow (GLOW) to predict molecular determinants and map free energy landscapes of biomolecules. All-atom ... -
Induction and inhibition of Drosophila X chromosome gene expression are both impeded by the dosage compensation complex
(Oxford University Press, 2022-07-06)Sex chromosomes frequently differ from the autosomes in the frequencies of genes with sexually dimorphic or tissue-specific expression. Multiple hypotheses have been put forth to explain the unique gene content of the X ...
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