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Molecular Biosciences: Recent submissions
Now showing items 801-820 of 887
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CONSERVED VIRUS PROTEIN FAMILIES IN BACTERIOPHAGE GENOMES AND IN METAGENOMES OF HUMANS
(University of Kansas, 2011-08-31)Viruses are likely to be the most abundant genomes in the biosphere, displaying remarkable molecular diversity. Their fast-evolving genomes and lack of universal marker genes make phylogenetic and taxonomic studies more ... -
ASTROCYTE-ENDOTHELIAL INTERACTIONS: IMPLICATIONS FOR HIV-ASSOCIATED NEUROCOGNITIVE DISORDER
(University of Kansas, 2011-08-31)During the course of HIV-1 disease, virus neuroinvasion occurs as an early event, within weeks following infection. Intriguingly, subsequent central nervous system (CNS) complications manifest only decades after the initial ... -
Tumor Suppressor APC and Musashi1: Double-Negative Feedback, Wnt Signaling and Colon Cancer
(University of Kansas, 2011-08-31)Colorectal cancer is the second leading cause of cancer related deaths in the United States. Approximately 80% of all colon cancers are associated with a mutation in the Adenomatous polyposis coli (APC) tumor suppressor ... -
MODELING PROTEIN INTERACTIONS THROUGH STRUCTURE ALIGNMENT
(University of Kansas, 2011-08-31)Rapid accumulation of the experimental data on protein-protein complexes drives the paradigm shift in protein docking from "traditional" template free approaches to template based techniques. Homology docking algorithms ... -
Interplay of chemical neurotransmitters regulates developmental increase in electrical synapses
(University of Kansas, 2011-08-31)Coupling of neurons by electrical synapses (gap junctions) transiently increases during embryonic and/or early postnatal development of the mammalian central nervous system and plays an important role in a number of ... -
Structure-function Study of PchB, an Isochorismate-Pyruvate Lyase from <italic>Pseudomonas aeruginosa</italic>
(University of Kansas, 2011-07-31)Enzymes act as biological catalysts for chemical reactions that would otherwise occur at rates insufficient for the survival and growth of an organism. Understanding the fundamental forces that drive catalysis in enzymes ... -
NMR Structural Studies of Type III Secretion System Tip Proteins
(University of Kansas, 2011-08-31)The type III secretion system (T3SS) is a complex set of regulatory and structural protein machinery common to many Gram-negative bacteria for virulence. Many of these bacterial species are human pathogens and cause a ... -
Surface Localization Determinants of Borrelia burgdorferi Lipoproteins
(University of Kansas, 2011-02-25)Borrelia spirochetes are the causative agents of Lyme disease and relapsing fever, two common vector-borne diseases. Early experimental evidence, gained from development of genetic tools in the Lyme disease spirochete, ... -
ESTROGEN RECEPTOR REGULATION OF GLUCOSE AND FAT METABOLISM IN THE SKELETAL MUSCLE AND ADIPOSE TISSUE
(University of Kansas, 2011-04-18)Clinical studies suggest that postmenopausal women are at an increased risk for type 2 diabetes (T2D), and hormone replacement therapy can ameliorate this risk. Considerable clinical and experimental evidence exists ... -
NMR STUDIES OF THE GLYCOPROTEIN CYTOPLASMIC TAILS OF HANTAVIRUS AND CRIMEAN CONGO HEMORRHAGIC FEVER VIRUS
(University of Kansas, 2011-04-25)The Bunyaviridae family of viruses is a diverse grouping of approximately 350 members that is present throughout the world. Viruses range from the innocuous to the severely pathogenic and impact not only public health, but ... -
Yeast Chemical Genetics For Identifying Regulators of Late Secretory Traffic Pathways
(University of Kansas, 2011-04-25)Abstract The intracellular transport of proteins and membrane lipids to the cell surface or between organelles is a fundamental process in eukaryotic cells. This process is required for the biogenesis and maintenance of ... -
EXC-5 Controls Intracellular Trafficking in Order to Maintain the Apical Structure of the C. elegans Excretory Canal
(University of Kansas, 2011-04-26)The goal of this work is to understand how cells form and maintain tubular shapes. The protein EXC-5 is necessary for a small tubular structure in Caenorhabditis elegans to maintain its shape. C. elegans is a small, easily ... -
STRUCTURAL AND FUNCTIONAL STUDIES OF AN ATYPICAL OMPR/PHOB TRANSCRIPTIONAL REGULATOR, CHXR, FROM CHLAMYDIA TRACHOMATIS
(University of Kansas, 2011-04-18)Chlamydia infections have an immense impact on public health and are associated with diverse disease manifestations including atherosclerosis, blindness, and sterility. The chlamydial developmental cycle is intrinsically ... -
The specification and patterning of the Drosophila egg chamber
(University of Kansas, 2010-12-07)The generation of cell polarity through the localization of specific mRNAs and proteins to discrete subcellular sites is fundamental to asymmetric cell division, tissue morphogenesis, cell migration, and most other ... -
RNA Helicase 1 interacts with an ABCRNAi Transporter: Genetic Interactions with haf-6
(University of Kansas, 2010-12-03)The C. elegans rha-1 gene encodes a conserved helicase with ATP-dependent DEAD/H-box and double-stranded RNA binding domains. rha-1 is orthologous to the Drosophila maleless gene(MLE), an essential component of the dosage ... -
AN AXON'S JOURNEY TO FIND ITS PATH: IN VIVO CHARACTERIZATION OF THE MODULATORS AND EFFECTORS OF THE RAC GTPASE SIGNALING PATHWAY INVOLVED IN AXON GUIDANCE
(University of Kansas, 2011-04-11)The molecular mechanisms leading to axonal guidance are vital for the proper wiring of the nervous system. Many psychiatric disorders may arise from the improper development of the brain. If an axon does not form, or is ... -
WATCHING NEURONS GROW: GUIDANCE RECEPTORS, SIGNAL TRANSDUCTION MACHINERY AND CYTOSKELETAL REGULATORS AFFECT GROWTH CONE MORPHOLOGY AND DYNAMICS IN C. ELEGANS
(University of Kansas, 2011-04-11)The growth cone of a developing axon senses and responds to extracellular cues resulting in the migration of the growth cone and thus the axon to the correct target in the nervous system. Growth cones display dynamic, ... -
Mitotic SUMOylation: from the mechanism to functions
(University of Kansas, 2010-08-10)ABSTRACT Protein modification by conjugation of SUMO molecules to target proteins is an essential process for both genomic stability and cell viability. In vertebrates, the SUMOylation process involves three SUMO paralogues, ... -
Parkin, A Top Level Manager in the Cell’s Sanitation Department
(Bentham, 2011)Parkin belongs to a class of multiple RING domain proteins designated as RBR (RING, in between RING, RING) proteins. In this review we examine what is known regarding the structure/function relationship of the Parkin ... -
MECHANISMS OF MICROVASCULAR INFLAMMATION INDUCED BY ALVEOLAR HYPOXIA
(University of Kansas, 2010-08-23)Alveolar hypoxia is observed in a number of clinical settings, and is frequently associated with systemic effects, many of which present an inflammatory component. Reduction of alveolar PO2 in rats induces a rapid and ...