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Molecular Biosciences: Recent submissions
Now showing items 821-840 of 887
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The Role of the G-Protein Coupled Receptor C-C Chemokine Receptor 7 in T Lymphocyte Migration and Breast Cancer Metastasis
(University of Kansas, 2010-08-23)C-C Chemokine Receptor 7 (CCR7) promotes migration of T lymphocytes into and throughout lymph nodes via ligands CCL21 and CCL19. The mechanisms by which CCR7 directs T lymphocyte trafficking are unknown. Using migration ... -
A Role for Adiponectin in Trophoblast Function
(University of Kansas, 2010-07-28)As the ultimate mediator of fetal growth and well-being, the placenta is inundated with a number of molecular cues from both the maternal and fetal systems. Successful integration of these signals is critical to the ongoing ... -
Sec61α is Required for Dorsal Closure during Drosophila Embryogenesis through its Regulation of Dpp Signaling
(John Wiley and sons, 2010-01-28)During dorsal closure in Drosophila, signaling events in the dorsalmost row of epidermal cells (DME cells) direct the migration of lateral epidermal sheets towards the dorsal midline where they fuse to enclose the embryo. ... -
uninflatable Encodes a Novel Ectodermal Apical Surface Protein Required for Tracheal Inflation in Drosophila
(Elsevier, 2009-10-07)The tracheal system of Drosophila melanogaster has proven to be an excellent model system for studying the development of branched tubular organs. Mechanisms regulating the patterning and initial maturation of the tracheal ... -
A Second-Site Noncomplementation Screen for Modifiers of Rho1 Signaling during Imaginal Disc Morpogenesis in Drosophila
(Public Library of Science, 2009-10-23)Background: Rho1 is a small GTPase of the Ras superfamily that serves as the central component in a highly conserved signaling pathway that regulates tissue morphogenesis during development in all animals. Since there is ... -
Molecular analysis of mammalian adenylyl cyclases and edema factor, a bacterial adenylyly cyclase toxin
(University of Kansas, 2008-12-16)Adenylyl cyclases (ACs) catalyze the conversion of ATP to cAMP, an important second messenger central to many signaling pathways. Nine different isoforms of mammalian ACs (mACs) are present, each with distinct localization, ... -
CATALYSIS AND INHIBITION OF MYCOBACTERIUM TUBERCULOSIS METHIONINE AMINOPEPTIDASE
(University of Kansas, 2010-06-04)Tuberculosis, caused by Mycobacterium tuberculosis, is the leading cause of death due to infectious disease. Now, the prevalence of multidrug-resistant and extensively drug-resistant TB, and the emergence of co-infection ... -
Molecular Mechanism of Parvovirus Infection
(University of Kansas, 2010-06-25)The studies to be presented are composed of two parts: 1) investigating the molecular mechanisms underlying cytopathic effects induced during infections of parvovirus B19 (B19V) and minute virus of canines (MVC); 2) ... -
Biochemical and Developmental Characterization of a SNF2-like ATPase Amplified in Liver Cancer 1 (ALC1)
(University of Kansas, 2010-06-07)Post-translational modifications play a key role in recruiting chromatin remodeling and modifying enzymes to specific regions of chromosomes to modulate chromatin structure. Alc1 (Amplified in Liver Cancer 1), a member of ... -
Spatial Regulation of Cell Division by the Min System in E. coli
(University of Kansas, 2010-05-04)The E. coli Min system contributes to spatial regulation of cell division by preventing Z ring assembly at cell poles. Critical to our understanding of this spatial regulation by the Min system is the mechanism of action ... -
Regulation of sympathetic plasticity in the heart
(University of Kansas, 2009-09-02)Following myocardial infarction, elevated sympathetic neuronal sprouting at the infarct border region leads to hyperexcitability which increases the risk of arrhythmias and sudden cardiac death. Surviving individuals with ... -
Characterization of the roles of the Nck interacting kinase MIG-15 and the Rac GTPases in neuronal migration in Caenorhabditis elegans.
(University of Kansas, 2010-04-23)Neuronal migration is essential to the formation of the central nervous system in vertebrates. In Caenorhabditis elegans, a screen was performed previously to identify mutations that affected the migration of the Q neuroblast ... -
Forward and reverse genetic approaches to identify genes involved in leg morphogenesis in Drosophila
(University of Kansas, 2010-04-26)Development of Drosophila leg imaginal discs provides an ideal model to study hormone-regulated morphogenesis. During the onset of metamorphosis, a pulse of ecdysone triggers the rapid transformation of flat leg imaginal ... -
USE OF ANIMAL FREE COMPONENTS IN THE COMMERCIAL MANUFACTURE OF VETERINARY CLOSTRIDIAL ANTIGENS
(University of Kansas, 2010-04-21)The use of animal-origin components and media in the commercial production of clostridial antigens for veterinary vaccine manufacture constitutes an unnecessary and excessive risk to food safety and health. For over 70 ... -
Investigation of the Structure and Function of Type III Secretion Needle and Tip Proteins
(University of Kansas, 2009-04-22)Many Gram-negative pathogens possess type III secretion systems as part of their required virulence factor repertoire. The type III secretion apparatus (TTSA) spans the bacterial inner and outer membranes and resembles a ... -
Mechanistic and Structural Studies of Salicylate Biosynthesis in Pseudomonas aeruginosa
(University of Kansas, 2009-04-29)Iron is an essential element for most pathogenic bacteria. To survive and establish infections in host tissues, these pathogens must compete with the host organism for iron. One strategy is to excrete iron-chelator ... -
Pseudophosphorylation of tau modulates its function and induces AD-like changes
(University of Kansas, 2009-08-13)The microtubule associate protein tau, in a hyperphosphorylated form, loses its normal function and aggregates into insoluble paired-helical filaments (PHFs) in Alzheimer's disease (AD) and other tauopathies. The stoichiometry ... -
Mechanisms of Telomere Protection and Deprotection in Human Cells
(University of Kansas, 2009-07-31)Telomeres, the nucleo-protein complexes at the ends of linear chromosomes, have critical roles in genome stability, cancer, and aging. Early work by B. McClintock and H.J. Muller demonstrated that eukaryotic chromosome ... -
Neural Substrates of Insulin-Mediated Memory Facilitation in Early Alzheimer's Disease; The Impact of the Apolipoprotein E-Epsilon-4 Allele on Hippocampal Insulin Responses
(University of Kansas, 2009-01-10)Background: Several studies have demonstrated that insulin delivered by nasal spray acutely improves cognitive performance in early Alzheimer's disease. Furthermore, the apolipoprotein E-episilon-4 allele, a known AD risk ... -
Genetic Approaches to Study Tissue Morphogenesis in Drosophila
(University of Kansas, 2009-12-03)Morphogenesis is defined as the change of body shape over time, the understanding of which is one of the central questions of developmental biology. To achieve proper overall organ and body shape, morphogenetic movements ...