ATTENTION: The software behind KU ScholarWorks is being upgraded to a new version. Starting July 15th, users will not be able to log in to the system, add items, nor make any changes until the new version is in place at the end of July. Searching for articles and opening files will continue to work while the system is being updated.
If you have any questions, please contact Marianne Reed at mreed@ku.edu .
Molecular Biosciences: Recent submissions
Now showing items 721-740 of 887
-
Natural and Unanticipated Modifiers of RNAi Activity in Caenorhabditis elegans
(Public Library of Science, 2012-11-28)Organisms used as model genomics systems are maintained as isogenic strains, yet evidence of sequence differences between independently maintained wild-type stocks has been substantiated by whole-genome resequencing data ... -
Altered Mitochondrial Retrograde Signaling in Response to mtDNA Depletion or a Ketogenic Diet
(University of Kansas, 2012-12-31)Neurodegenerative diseases affect a staggering proportion of the population. Many neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, and Parkinson's disease exhibit significant metabolic ... -
Oogenesis in Unisexual Whiptail Lizards (genus Aspidoscelis)
(University of Kansas, 2012-12-31)Parthenogenesis is a reproductive mode that does not require males. Though theoretically advantageous, its rarity among metazoans suggests otherwise. Paradoxically, some unisexual species within the genus Aspidoscelis ... -
Genetic Analysis of Allosteric Signaling in RhaR from Escherichia coli and Characterization of the VirF Protein from Shigella flexneri
(University of Kansas, 2013-12-31)The RhaR and VirF proteins are both members of the large AraC family of bacterial transcription regulators. RhaR activates expression of the Escherichia coli rhaSR operon in response to the effector L-rhamnose while VirF ... -
Molecular Mechanisms and Inhibition of Transcription Activation by Bacterial AraC Family Activator Proteins
(University of Kansas, 2013-12-31)AraC family proteins are transcriptional regulators that are defined by the presence of a conserved DNA binding domain (DBD). My research focused on three AraC family activators: Rns (activator of virulence genes in ... -
IN VITRO SUSCEPTIBILITY OF CHLAMYDIA TRACHOMATIS TO LPS-BINDING POLYAMINES AND CELLULOSE ETHER POLYMERS: TOWARDS THE DEVELOPMENT OF A MICROBICIDE AGAINST CHLAMYDIA INFECTION
(University of Kansas, 2013-12-31)Chlamydia trachomatis is the causative agent of the most prevalent sexually transmitted bacterial infection in the United States. Antibiotic therapy is currently effective in treating Chlamydia infection; however, the vast ... -
On the electrostatic component of protein-protein binding free energy
(BioMed Central, 2008-11-05)Calculations of electrostatic properties of protein-protein complexes are usually done within framework of a model with a certain set of parameters. In this paper we present a comprehensive statistical analysis of the ... -
Functional transcriptomic analysis of the role of MAB-5/Hox in Q neuroblast migration in Caenorhabditis elegans
(BioMed Central, 2013-05-04)Background: Directed cell migration is a fundamental process in normal development and in tumor metastasis. In C. elegans the MAB-5/Hox transcription factor is a determinant of posterior migration of the Q neuroblast ... -
GSK-3β phosphorylation of functionally distinct tau isoforms has differential, but mild effects
(BioMed Central, 2009-05-02)Background: Tau protein exists as six different isoforms that differ by the inclusion or exclusion of exons 2, 3 and 10. Exon 10 encodes a microtubule binding repeat, thereby resulting in three isoforms with three microtubule ... -
RNA-Seq analysis of two brain regions vulnerable to Alzheimer's disease
(BioMed Central, 2012-10-01) -
Transcriptomic responses in mouse brain exposed to chronic excess of the neurotransmitter glutamate
(BioMed Central, 2010-06-07)Background: Increases during aging in extracellular levels of glutamate (Glu), the major excitatory neurotransmitter in the brain, may be linked to chronic neurodegenerative diseases. Little is known about the molecular ... -
Genomic and biochemical approaches in the discovery of mechanisms for selective neuronal vulnerability to oxidative stress
(BioMed Central, 2009-02-19)Background: Oxidative stress (OS) is an important factor in brain aging and neurodegenerative diseases. Certain neurons in different brain regions exhibit selective vulnerability to OS. Currently little is known about the ... -
Ab initio modeling of small proteins by iterative TASSER simulations
(BioMed Central, 2007-05-08)Background: Predicting 3-dimensional protein structures from amino-acid sequences is an important unsolved problem in computational structural biology. The problem becomes relatively easier if close homologous proteins ... -
The BioAssay network and its implications to future therapeutic discovery
(BioMed Central, 2011-07-27)Background: Despite intense investment growth and technology development, there is an observed bottleneck in drug discovery and development over the past decade. NIH started the Molecular Libraries Initiative (MLI) in 2003 ... -
Tau phosphorylation by GSK-3β promotes tangle-like filament morphology
(BioMed Central, 2007-06-28)Background Neurofibrillary tangles (NFTs) are intraneuronal aggregates associated with several neurodegenerative diseases including Alzheimer's disease. These abnormal accumulations are primarily comprised of fibrils of ... -
I-TASSER server for protein 3D structure prediction
(BioMed Central, 2008-01-23)Background: Prediction of 3-dimensional protein structures from amino acid sequences represents one of the most important problems in computational structural biology. The community-wide Critical Assessment of Structure ... -
The Arp2/3 Complex, UNC-115/abLIM, and UNC-34/Enabled Regulate Axon Guidance and Growth Cone Filopodia Formation in Caenorhabditis Elegans
(BioMed Central, 2009-10-02)Background While many molecules involved in axon guidance have been identified, the cellular and molecular mechanisms by which these molecules regulate growth cone morphology during axon outgrowth remain to be elucidated. ... -
GWIDD: a comprehensive resource for genome-wide structural modeling of protein-protein interactions
(BioMed Central, 2012-07-11)Protein-protein interactions are a key component of life processes. The knowledge of the three-dimensional structure of these interactions is important for understanding protein function. Genome-Wide Docking Database ... -
Correlation analysis of the side-chains conformational distribution in bound and unbound proteins
(BioMed Central, 2012-09-17)Background: Protein interactions play a key role in life processes. Characterization of conformational properties of protein-protein interactions is important for understanding the mechanisms of protein association. The ... -
The C. elegans EMAP-like protein, ELP-1 is required for touch sensation and associates with microtubules and adhesion complexes
(BioMed Central, 2008-11-17)Background: The founding member of the EMAP-like protein family is the Echinoderm Microtubule-Associated Protein (EMAP), so-named for its abundance in sea urchin, starfish, and sand dollar eggs. The EMAP-like protein family ...