ATTENTION: The software behind KU ScholarWorks is being upgraded to a new version. Starting July 15th, users will not be able to log in to the system, add items, nor make any changes until the new version is in place at the end of July. Searching for articles and opening files will continue to work while the system is being updated.
If you have any questions, please contact Marianne Reed at mreed@ku.edu .
Molecular Biosciences: Recent submissions
Now showing items 301-320 of 887
-
Global and local structural similarity in protein–protein complexes: Implications for template-based docking
(Wiley, 2013-12)The increasing amount of structural information on protein–protein interactions makes it possible to predict the structure of protein–protein complexes by comparison/alignment of the interacting proteins to the ones in ... -
Docking by structural similarity at protein-protein interfaces
(Wiley, 2010-11-15)Rapid accumulation of experimental data on protein-protein complexes drives the paradigm shift in protein docking from ‘traditional,’ template free approaches to template based techniques. Homology docking algorithms based ... -
Macroglobulin complement-related, coracle and Neuroglian are required for Drosophila egg morphogenesis
(University of Kansas, 2016-05-31)Morphogenesis, along with cell growth and differentiation are crucial processes that define the body plan of an organism. Morphogenetic movements such as neural tube formation, gastrulation and organogenesis are accomplished ... -
Blind Prediction of Interfacial Water Positions in CAPRI
(Wiley, 2014-04)We report the first assessment of blind predictions of water positions at protein-protein interfaces, performed as part of the CAPRI (Critical Assessment of Predicted Interactions) community-wide experiment. Groups submitting ... -
Amino acid positions subject to multiple co-evolutionary constraints can be robustly identified by their eigenvector network centrality scores
(Wiley, 2015-12)As proteins evolve, amino acid positions key to protein structure or function are subject to mutational constraints. These positions can be detected by analyzing sequence families for amino acid conservation or for ... -
Structural and functional studies of the phage Sf6 terminase small subunit reveal a DNA-spooling device facilitated by structural plasticity
(Elsevier, 2012-07-31)In many DNA viruses, genome packaging is initiated by the small subunit of the packaging terminase, which specifically binds to the packaging signal on viral DNA and directs assembly of the terminase holoenzyme. We have ... -
The LcrG tip chaperone protein of the Yersinia pestis type III secretion system is partially folded
(Elsevier, 2015-08-07)The type III secretion system (T3SS) is essential in the pathogenesis of Yersinia pestis, the causative agent of plague. A small protein, LcrG, functions as a chaperone to the tip protein LcrV, and the LcrG-LcrV interaction ... -
NMR Model of PrgI-SipD Interaction and its Implications in the Needle-Tip Assembly of the Salmonella Type III Secretion System
(Elsevier, 2014-06-18)Salmonella and other pathogenic bacteria use the type III secretion system (T3SS) to inject virulence proteins into human cells to initiate infections. The structural component of the T3SS contains a needle and a needle ... -
Double-layered hyaluronic acid/stearic acid-modified polyethyleneimine nanoparticles encapsulating (-)-gossypol: a nanocarrier for chiral anticancer drugs
(Royal Society of Chemistry, 2014-08-28)This study aimed to enhance the water solubility and antitumor efficacy of (-)-gossypol. Polyethyleneimine conjugated with stearic acid (PgS) was used for loading and protecting (-)-gossypol through hydrogen bonding. ... -
Molecular Genetic Characterization of the Biosynthesis Cluster of a Prenylated Isoindolinone Alkaloid Aspernidine A in Aspergillus nidulans
(American Chemical Society, 2013-06-07)Aspernidine A is a prenylated isoindolinone alkaloid isolated from the model fungus Aspergillus nidulans. A genome-wide kinase knock out library of A. nidulans was examined and it was found that a mitogen-activated protein ... -
Molecular genetic characterization of a cluster in A. terreus for biosynthesis of the meroterpenoid terretonin
(American Chemical Society, 2012-11-16)Meroterpenoids are natural products produced from polyketide and terpenoid precursors. A gene targeting system for A. terreus NIH2624 was developed and a gene cluster for terretonin biosynthesis was characterized. The ... -
A study of the chlorination of milk
(University of Kansas, 1929) -
An Improved D-α-Tocopherol-Based Nanocarrier for Targeted Delivery of Doxorubicin with Reversal of Multidrug Resistance
(Elsevier, 2014-10-24)Nanocarriers have recently emerged as an attractive platform for delivery of various types of therapeutics including anticancer agents. Previously, we developed an improved TPGS delivery system (PEG5K-VE2) which demonstrated ... -
Identification of a Small Molecule Inhibitor of Bacterial AraC Family Activators
(SAGE Publications, 2013-01-30)Protein members of the AraC family of bacterial transcriptional activators have great promise as targets for the development of novel antibacterial agents. Here, we describe an in vivo high throughput screen to identify ... -
Deferiprone modulates in vitro responses by peripheral blood T cells from control and relapsing remitting multiple sclerosis subjects
(Elsevier, 2012-11-01)T cells are important mediators of autoimmune inflammation in relapsing remitting multiple sclerosis (RRMS). Previous studies found that deferiprone, an iron chelator, suppressed disease activity in a mouse model of multiple ... -
Distinct tissue distributions and subcellular localizations of differently phosphorylated forms of the myosin regulatory light chain in Drosophila
(Elsevier, 2012-01-01)Nonmuscle myosin II (myosin hereafter) has well-established roles in generating contractile force on actin filaments during morphogenetic processes in all metazoans. Myosin activation is regulated by phosphorylation of the ... -
HSV-1 ICP0: paving the way for viral replication
(Future Medicine, 2012-02-01)Herpes simplex virus type 1 (HSV-1) has two distinct phases of its viral life cycle: lytic and latent. One viral immediate-early protein that is responsible for determining the balance between productive lytic replication ... -
The FGD Homologue EXC-5 Regulates Apical Trafficking in C. elegans Tubules
(Elsevier, 2012-11-01)Maintenance of the shape of biological tubules is critical for development and physiology of metazoan organisms. Loss of function of the C. elegans FGD protein EXC-5 allows large fluid-filled cysts to form in the lumen of ... -
The Fat-like Cadherin CDH-4 Acts Cell-Non-Autonomously in Anterior-Posterior Neuroblast Migration
(Elsevier, 2015-08-15)Directed migration of neurons is critical in the normal and pathological development of the brain and central nervous system. In C. elegans, the bilateral Q neuroblasts, QR on the right and QL on the left, migrate anteriorly ... -
Preferential adhesion maintains separation of ommatidia in the Drosophila eye
(Elsevier, 2011-08-15)In the Drosophila eye, neighboring ommatidia are separated by inter-ommatidial cells (IOCs). How this ommatidial spacing emerges during eye development is not clear. Here we demonstrate that four adhesion molecules of the ...