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    Molecular Genetic Characterization of the Biosynthesis Cluster of a Prenylated Isoindolinone Alkaloid Aspernidine A in Aspergillus nidulans

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    Oakley_2013.pdf (929.3Kb)
    Issue Date
    2013-06-07
    Author
    Yaegashi, Junko
    Praseuth, Mike B.
    Tyan, Shaiw-Wei
    Sanchez, James F.
    Entwistle, Ruth A.
    Chiang, Yi-Ming
    Oakley, Berl R.
    Wang, Clay C. C.
    Publisher
    American Chemical Society
    Type
    Article
    Article Version
    Scholarly/refereed, publisher version
    Rights
    This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/ol401187b.
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    Abstract
    Aspernidine A is a prenylated isoindolinone alkaloid isolated from the model fungus Aspergillus nidulans. A genome-wide kinase knock out library of A. nidulans was examined and it was found that a mitogen-activated protein kinase gene, mpkA, deletion strain produces aspernidine A. Targeted gene deletions were performed in the kinase deletion background to identify the gene cluster for aspernidine A biosynthesis. Intermediates were isolated from mutant strains which provided information about the aspernidine A biosynthesis pathway.
    URI
    http://hdl.handle.net/1808/23478
    DOI
    https://doi.org/10.1021/ol401187b
    Collections
    • Molecular Biosciences Scholarly Works [537]
    Citation
    Yaegashi, J., Praseuth, M. B., Tyan, S.-W., Sanchez, J. F., Entwistle, R., Chiang, Y.-M., … Wang, C. C. C. (2013). Molecular Genetic Characterization of the Biosynthesis Cluster of a Prenylated Isoindolinone Alkaloid Aspernidine A in Aspergillus nidulans. Organic Letters, 15(11), 2862–2865. http://doi.org/10.1021/ol401187b

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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