Molecular Genetic Characterization of the Biosynthesis Cluster of a Prenylated Isoindolinone Alkaloid Aspernidine A in Aspergillus nidulans

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Issue Date
2013-06-07Author
Yaegashi, Junko
Praseuth, Mike B.
Tyan, Shaiw-Wei
Sanchez, James F.
Entwistle, Ruth A.
Chiang, Yi-Ming
Oakley, Berl R.
Wang, Clay C. C.
Publisher
American Chemical Society
Type
Article
Article Version
Scholarly/refereed, publisher version
Rights
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/ol401187b.
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Show full item recordAbstract
Aspernidine A is a prenylated isoindolinone alkaloid isolated from the model fungus Aspergillus nidulans. A genome-wide kinase knock out library of A. nidulans was examined and it was found that a mitogen-activated protein kinase gene, mpkA, deletion strain produces aspernidine A. Targeted gene deletions were performed in the kinase deletion background to identify the gene cluster for aspernidine A biosynthesis. Intermediates were isolated from mutant strains which provided information about the aspernidine A biosynthesis pathway.
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Citation
Yaegashi, J., Praseuth, M. B., Tyan, S.-W., Sanchez, J. F., Entwistle, R., Chiang, Y.-M., … Wang, C. C. C. (2013). Molecular Genetic Characterization of the Biosynthesis Cluster of a Prenylated Isoindolinone Alkaloid Aspernidine A in Aspergillus nidulans. Organic Letters, 15(11), 2862–2865. http://doi.org/10.1021/ol401187b
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