Molecular genetic characterization of a cluster in A. terreus for biosynthesis of the meroterpenoid terretonin

Guo, Chun-Jun; Knox, Benjamin P.; Chiang, Yi-Ming; Lo, Hsien-Chun; Sanchez, James F.; Lee, Kuan-Han; Oakley, Berl R.; Bruno, Kenneth S.; Wang, Clay C. C.

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Issue Date

2012-11-16

Author

Guo, Chun-Jun

Knox, Benjamin P.

Chiang, Yi-Ming

Lo, Hsien-Chun

Sanchez, James F.

Lee, Kuan-Han

Oakley, Berl R.

Bruno, Kenneth S.

Wang, Clay C. C.

Publisher

American Chemical Society

Type

Article

Article Version

Scholarly/refereed, author accepted manuscript

Rights

This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/ol302682z..

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Abstract

Meroterpenoids are natural products produced from polyketide and terpenoid precursors. A gene targeting system for A. terreus NIH2624 was developed and a gene cluster for terretonin biosynthesis was characterized. The intermediates and shunt products were isolated from the mutant strains and a pathway for terretonin biosynthesis is proposed. Analysis of two meroterpenoid pathways corresponding to terretonin in A. terreus and austinol in A. nidulans reveals that they are closely related evolutionarily.

Citation

Guo, C.-J., Knox, B. P., Chiang, Y.-M., Lo, H.-C., Sanchez, J. F., Lee, K.-H., … Wang, C. C. C. (2012). Molecular genetic characterization of a cluster in A. terreus for biosynthesis of the meroterpenoid terretonin. Organic Letters, 14(22), 5684–5687. http://doi.org/10.1021/ol302682z

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