Molecular genetic characterization of a cluster in A. terreus for biosynthesis of the meroterpenoid terretonin
View/ Open
Issue Date
2012-11-16Author
Guo, Chun-Jun
Knox, Benjamin P.
Chiang, Yi-Ming
Lo, Hsien-Chun
Sanchez, James F.
Lee, Kuan-Han
Oakley, Berl R.
Bruno, Kenneth S.
Wang, Clay C. C.
Publisher
American Chemical Society
Type
Article
Article Version
Scholarly/refereed, author accepted manuscript
Rights
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/ol302682z..
Metadata
Show full item recordAbstract
Meroterpenoids are natural products produced from polyketide and terpenoid precursors. A gene targeting system for A. terreus NIH2624 was developed and a gene cluster for terretonin biosynthesis was characterized. The intermediates and shunt products were isolated from the mutant strains and a pathway for terretonin biosynthesis is proposed. Analysis of two meroterpenoid pathways corresponding to terretonin in A. terreus and austinol in A. nidulans reveals that they are closely related evolutionarily.
Collections
Citation
Guo, C.-J., Knox, B. P., Chiang, Y.-M., Lo, H.-C., Sanchez, J. F., Lee, K.-H., … Wang, C. C. C. (2012). Molecular genetic characterization of a cluster in A. terreus for biosynthesis of the meroterpenoid terretonin. Organic Letters, 14(22), 5684–5687. http://doi.org/10.1021/ol302682z
Items in KU ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
We want to hear from you! Please share your stories about how Open Access to this item benefits YOU.