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    Molecular genetic characterization of a cluster in A. terreus for biosynthesis of the meroterpenoid terretonin

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    Oakley_2012.pdf (1.574Mb)
    Issue Date
    2012-11-16
    Author
    Guo, Chun-Jun
    Knox, Benjamin P.
    Chiang, Yi-Ming
    Lo, Hsien-Chun
    Sanchez, James F.
    Lee, Kuan-Han
    Oakley, Berl R.
    Bruno, Kenneth S.
    Wang, Clay C. C.
    Publisher
    American Chemical Society
    Type
    Article
    Article Version
    Scholarly/refereed, author accepted manuscript
    Rights
    This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/ol302682z..
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    Abstract
    Meroterpenoids are natural products produced from polyketide and terpenoid precursors. A gene targeting system for A. terreus NIH2624 was developed and a gene cluster for terretonin biosynthesis was characterized. The intermediates and shunt products were isolated from the mutant strains and a pathway for terretonin biosynthesis is proposed. Analysis of two meroterpenoid pathways corresponding to terretonin in A. terreus and austinol in A. nidulans reveals that they are closely related evolutionarily.
    URI
    http://hdl.handle.net/1808/23477
    DOI
    https://doi.org/10.1021/ol302682z
    Collections
    • Molecular Biosciences Scholarly Works [537]
    Citation
    Guo, C.-J., Knox, B. P., Chiang, Y.-M., Lo, H.-C., Sanchez, J. F., Lee, K.-H., … Wang, C. C. C. (2012). Molecular genetic characterization of a cluster in A. terreus for biosynthesis of the meroterpenoid terretonin. Organic Letters, 14(22), 5684–5687. http://doi.org/10.1021/ol302682z

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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