Pharmacy Dissertations and Theses: Recent submissions
Now showing items 41-60 of 118
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MECHANISMS OF LIVER REGENERATION AFTER ACETAMINOPHEN-INDUCED HEPATOTOXICITY IN MICE
(University of Kansas, 2016-08-31)Overdose of acetaminophen (APAP) is the major cause of acute liver failure (ALF) in the western world with very limited treatment options. Recent studies suggest that liver regeneration is a critical determinant of final ... -
Estrogen Receptor β Regulates Brain Signaling Involved in Depression
(University of Kansas, 2016-08-31)Depression, a common, costly and recurrent disorder is associated with considerable morbidity and excess mortality. Several epidemiological and clinical studies have reported that women exhibit an increased risk for ... -
The chemistry of the blood in measles
(University of Kansas, 1932) -
Role of Yes-Associated Protein (YAP) in Liver Injury and Regeneration following Acetaminophen Overdose
(University of Kansas, 2016-12-31)Acetaminophen (APAP) overdose is the major cause of Acute Liver Failure (ALF) in the Western world. Treatment options for APAP-induced ALF are limited. Studies have shown that stimulating liver regeneration could be a ... -
Identification and characterization of the transporters involved in the disposition of perfluoroalkyl substances
(University of Kansas, 2016-12-31)Perfluoroalkyl substances (PFASs), including perfluoroalkyl carboxylates (PFCAs) and perfluoroalkyl sulfonates (PFSAs), are persistent amphiphilic chemicals many of which are distributed ubiquitously in the environment and ... -
Gene by Environment Interaction Leads to Sensitivity to the Anti-Aggressive Effect of Δ9-Tetrahydrocannabinol
(University of Kansas, 2016-12-31)Pathological reactive aggression is a neurodevelopmental disorder characterized by exaggerated violent and explosive responses that are disproportionate to provocation, and a propensity for cannabis abuse. The susceptibility ... -
Alterations in bile acid homeostasis and drug metabolism in germ-free mice
(University of Kansas, 2014-08-31)"We may be born 100% human but will die 90% bacterial--a truly complex organism!" (Goodacre, 2007). This statement reflects the fact that there are 10 times more bacterial cells in the human body compared to the number of ... -
Novologue Therapy Improves Mitochondrial Bioenergetics and Modulates Transcriptome Changes in Diabetic Sensory Neurons
(University of Kansas, 2015-05-31)Diabetic peripheral neuropathy (DPN) is a prevalent diabetic complication with scarce treatment options. Impaired neuronal mitochondrial bioenergetics contributes to the pathophysiologic progression of DPN and may be a ... -
ACETAMINOPHEN HEPATOTOXICITY IN PRIMARY HUMAN HEPATOCYTES AND MICE
(University of Kansas, 2016-05-31)Acetaminophen is the most prevalent cause of acute liver failure (ALF) and drug-induced liver injury (DILI) in western countries. Extensive studies have revealed important intracellular events during the pathogenesis after ... -
Identifying Novel Inhibitors of Epithelial to Mesenchymal Transition (EMT) for Targeting Pancreatic Cancer Metastasis and Cancer Stem Cells
(University of Kansas, 2015-12-31)Pancreatic cancer is the fourth leading cause of cancer-related death in the United States, and it is expected to become the second-leading cause of cancer-related death by 2030. Currently, there are no early detection ... -
REGULATION OF DENDRITIC SPINES BY 5-HT2A RECEPTOR SIGNALING PATHWAYS
(University of Kansas, 2015-12-31)Dendritic spines are small membranous protrusions from the dendrites of neuron, which are thought to serve as basic units of synaptic transmission, learning and memory. Disruptions in dendritic spine shape, size or number ... -
UBIQUITINATION AND SUMOYLATION OF PREGNANE X RECEPTOR
(University of Kansas, 2015-05-31)Abstract Pregnane X receptor (PXR, NR1I2) is a ligand-activated nuclear receptor (NR) superfamily member expressed at high levels in the liver and intestine of mammals. PXR can be activated by a broad range of structurally ... -
Intervention with the Hsp90 Modulator KU-32 Improves Chronic Experimental Diabetic Neuropathy
(University of Kansas, 2015-05-31)Inducing the heat shock response (HSR) through Hsp90 inhibition augments heat shock protein (Hsp) support and may improve several aspects of neurodegenerative phenotypes. Several Hsps serve as molecular chaperones that ... -
HSD10 Regulates Cancer Cell Growth and Resistance to Cell Death
(University of Kansas, 2016-05-31)Dysfunction or deregulation of certain cellular processes is commonly used to distinguish known illnesses into separate and unique disease states. Although each cancer type is individually distinct, most cancers initially ... -
THE ROLE OF PIAS PROTEINS IN THE SUMOYLATION OF 5-HT1A RECEPTORS
(University of Kansas, 2016-05-31)Serotonin 1A receptors (5-HT1A Rs) are implicated in the control of mood, cognition and memory. Dysfunction of 5-HT1A R signaling results in various neuropsychiatric disorders such as depression, anxiety and schizophrenia. ... -
The Dual Role of Hypoxia-Inducible Factor-1 in Ischemic Stroke: Neuroprotection and Blood-Brain Barrier Disruption
(University of Kansas, 2014-08-31)Stroke is a major cause of death and the leading cause of long-term disability in industrialized countries. Ischemic stroke-induced brain injury results from the interaction of complex pathophysiological processes, including ... -
Differential expression of neuregulin-1 isoforms and downregulation of erbin are associated with Erb B2 receptor activation in diabetic peripheral neuropathy
(University of Kansas, 2014-05-31)Aberrant neuron-glia interactions can contribute to a variety of neurodegenerative diseases. We have previously demonstrated that enhanced activation of Erb B2, which is a member of the epidermal growth factor receptor ... -
Pregnane X Receptor SUMOylation and De-SUMOylation
(University of Kansas, 2014-05-31)The pregnane x receptor (PXR, NR1I2) is a member of the nuclear receptor (NR) superfamily of ligand-activated transcription factors. PXR is activated by numerous lipophilic compounds, a variety of drugs and drug metabolites ... -
The roles of Hypoxia Inducible Factor-1, Glutamate and their interaction in Ischemic Tolerance
(University of Kansas, 2014-05-31)Stroke is a debilitating disorder with no effective treatments. The clinical importance of promoting cerebral ischemic tolerance is apparent; however, our knowledge of the signaling mechanisms involved in the phenomenon ... -
Estradiol-induced desensitization of 5-HT1A receptor signaling
(University of Kansas, 2013-12-31)Depression is a common psychiatric illness, affecting over 120 million people worldwide. Women are affected disproportionately compared to men, and a large body of clinical evidence suggests a role for changes in estrogen ...