Pharmacy Dissertations and Theses: Recent submissions
Now showing items 21-40 of 118
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Clusterin in the Brain
(University of Kansas, 2017-12-31)Late-onset Alzheimer’s disease (LOAD) is an age-related chronic neurodegenerative disorder traditionally characterized by the presence of neurotoxic amyloid beta (Aβ) plaques, neurofibrillary tangles, and progressive, ... -
Targeting Heat Shock Protein 70 to Improve Oxidative Stress and Mitochondrial Bioenergetics in Diabetic Sensory Neurons
(University of Kansas, 2017-12-17)Neuronal mitochondrial dysfunction is a key pathophysiologic mechanism of diabetic peripheral neuropathy (DPN). KU-596 is a small molecule modulator of heat shock protein 90 (Hsp90) that can reverse clinically relevant ... -
CHARACTERIZATION OF MOLECULAR AND GENETIC DETERMINANTS OF POLY (ADP-RIBOSE) POLYMERASE INHIBITOR SENSITIVITY IN OVARIAN CANCER
(University of Kansas, 2018-05-31)Ovarian cancer is the most leathal cancer among gynecologic cancers in the United States and is the fifth leading cause of cancer death among American women. Approximately sixty percent of women with ovarian cancer are ... -
Targeting vulnerabilities through inhibiting the valosin-containing protein (VCP/p97) in ovarian cancer
(University of Kansas, 2018-05-31)Ovarian cancer is the fifth leading cause of cancer-related death among women and the deadliest of all gynecological cancers. Treatment failure is a major contributing factor in ovarian cancer-related mortality. Advances ... -
IDENTIFICATION AND CHARACTERIZATION OF THE OLIGOMERIZATION AND STRUCTURAL FUNCTIONAL RELATIONSHIP OF ORGANIC ANION TRANSPORTING POLYPEPTIDE 1B3
(University of Kansas, 2017-12-31)Many transporters are expressed at the basolateral membrane of human hepatocytes, including Organic Anion Transporting Polypeptide 1B1 (OATP1B1), OATP1B3, Organic Cation Transporter 1 (OCT1), Na+/Taurocholate Cotransporting ... -
IDENTIFICATION OF ENDOGENOUS FUNCTION AND SUBSTRATE-DEPENDENT INTERACTIONS OF ORGANIC CATION TRANSPORTER 1
(University of Kansas, 2018-05-31)The human organic cation transporter 1 (hOCT1) is a polyspecific transporter, primarily expressed in the liver, which is known to interact with a large number of structurally dissimilar compounds. Several clinically-relevant ... -
ROLE OF DNA DAMAGE RESPONSE IN LIVER REGENERATION AFTER APAP OVERDOSE INDUCED ALF
(University of Kansas, 2017-12-31)Acetaminophen (APAP) overdose is a leading cause of acute liver failure (ALF) with limited treatment options. The mechanisms of APAP-induced liver injury include formation of a reactive metabolite N-acetyl-p-quinoneimine ... -
Mechanistic Biomarkers in Acute Liver Injury
(University of Kansas, 2017-12-31)Acute liver failure continues to be a major medical problem. There are many underlying causes of acute liver failure, but drug induced liver injury is the most common. However, ischemic injury secondary to either liver ... -
The Role of O-GlcNAc in Liver Injury and Regeneration
(University of Kansas, 2017-12-31)O-GlcNAcylation is a covalent attachment of a single N-acetyl glucosamine to a serine or threonine residue of a protein. Unlike other forms of protein glycosylation, there is no chain elongation in O-GlcNAcylation. O-GlcNAc ... -
HEPATIC WOUND HEALING FOLLOWING ACUTE AND CHRONIC LIVER INJURY: A POTENTIAL ROLE FOR THE HYALURONAN NETWORK
(University of Kansas, 2017-08-31)Chronic liver disease is the 12th leading cause of death in the United States and consists of a continuum of pathologies. Following initial injury, a patient develops steatosis, or excess fat accumulation. While the liver ... -
MITOCHONDRIAL OXIDATIVE STRESS AND BIOGENESIS DURING ACETAMINOPHEN HEPATOTOXICITY
(University of Kansas, 2017-05-31)Acetaminophen (APAP) overdose causes severe hepatotoxicity in animals and humans. Although numerous studies have established the existence of an extensive oxidative stress during APAP hepatotoxicity, its source, ... -
Use of Task-Relevant Spoken Word Stimuli in an Auditory Brain-Computer Interface
(University of Kansas, 2017-05-31)Auditory brain-computer interfaces (aBCI) may be an effective solution for communication in cases of severely locked-in, late stage ALS (Lou Gehrig’s disease) and upper spinal cord injury patients who are otherwise not ... -
Characterization of a Novel Tau Aggregation Inhibitor Isolated from Fungal Secondary Metabolites
(University of Kansas, 2017-05-31)Alzheimer’s disease is the 6th leading cause of death in the U.S. and the cost of care is billions of dollars per year. Tau aggregation is a pathological hallmark in neurodegenerative diseases known as tauopathies, which ... -
PXR IN BRAIN: NOVEL METHODS TO CHARACTERIZE ITS BIOLOGY
(University of Kansas, 2017-05-31)Pregnane X receptor (PXR, NR1I2) belongs to the nuclear receptor superfamily of ligand-activated transcription factors and was identified in 1998. PXR is highly expressed in the liver and intestine, and is involved in ... -
IDENTIFYING FUNCTIONALLY SELECTIVE LIGANDS FOR THE SEROTONIN-2A RECEPTOR
(University of Kansas, 2017-05-31)Atypical antipsychotics are used to treat schizophrenia and although atypical antipsychotics helped improve the management of positive symptoms, many patients are still suffering from negative and cognitive symptoms and ... -
Methionine Sulfoxide Reductase and Ubiquitin-dependent Degradation of Alpha-synuclein
(University of Kansas, 2017-05-31)Alpha-synuclein (αSyn) is one of the key proteins considered to be involved in the pathogenesis of the Parkinson`s disease (PD) and being the main component of Lewy bodies (LBs). Studies on the αSyn gene mutants and ... -
Post-translational Modifications of Pregnant X Receptor
(University of Kansas, 2017-05-31)Pregnane X Receptor (PXR, NR1I2) is a member of the nuclear receptor (NR) superfamily of ligand-activated transcription factors. Expression levels of PXR are highest in the liver and intestine. The activation of PXR can ... -
Iron regulation and heat shock proteins in ischemic stroke
(University of Kansas, 2016-05-31)Ischemic stroke is one of the leading causes of brain injury and death. Many mechanisms underlying ischemia-induced neuronal death have been investigated. Dysregulation of brain iron homeostasis is one of these mechanisms. ... -
Perturbed Brain Energy Metabolism in Alzheimer’s Disease and Diabetes
(University of Kansas, 2017-05-31)The brain has high energy demands, which are met by the complete oxidation of glucose, the obligatory energy substrate for the brain under physiological conditions. Glucose oxidative metabolism consists of cytosolic processes ... -
Identification of sentrin specific proteases and SUMOylation sites of 5-HT1A receptors
(University of Kansas, 2017-08-31)The serotonin-1A receptor (5-HT1A-R) is an abundant 5-HT receptor located in both pre-synaptic and post-synaptic membranes of neurons. Activation of this receptor has been involved in the mechanism of action of antidepressant, ...