Pharmacy Dissertations and Theses: Recent submissions
Now showing items 61-80 of 118
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Agaricus-Montana
(University of Kansas, 1927) -
Regulation of Xenobiotic and Bile Acid Metabolism by the Anti-aging Intervention Calorie Restriction in Mice
(University of Kansas, 2013-05-31)Calorie restriction (CR), defined as reduced calorie intake without causing malnutrition, is the best-known intervention to increase life span and slow aging-related diseases in various species. However, current knowledge ... -
STUDY OF FXR IN PRIMARY HUMAN HEPATOCYTES AND FXR REGULATED BA HOMEOSTASIS IN PARENTERAL NUTRITION ASSOCIATED LIVER DISEASES
(University of Kansas, 2014-12-31)Farnesoid X receptor (FXR, NR1H4) is a ligand activated transcription factor belonging to the nuclear receptor (NR) superfamily, and is highly expressed in the liver, intestine, and kidney, in both humans and rodents. Bile ... -
The Role of Parkin and Mitophagy in Acetaminophen and Alcohol-induced Liver Injuries
(University of Kansas, 2015-01-01)Acetaminophen (APAP) is the leading cause of acute liver failure in the United States, and alcoholic liver disease (ALD) is a worldwide health problem that claims two million lives per year. Currently, the only cure for ... -
Development of Novel Fluorescence and NMR Reagents for Monitoring Protein-Protein Interactions Between Survivin and Its Protein Binding Partners
(University of Kansas, 2015-08-31)Inhibition of protein-protein interactions is a promising therapeutic strategy for targeting non-enzymatic proteins. One strategy to inhibit protein-protein interactions is to design inhibitors specifically toward the ... -
AN IN VITRO INVESTIGATION INTO THE MECHANISM OF THE CLINICALLY RELEVANT DRUG-DRUG INTERACTION BETWEEN OMEPRAZOLE OR ESOMEPRAZOLE AND CLOPIDOGREL
(University of Kansas, 2015-05-31)Clopidogrel is a thienopyridine antiplatelet prodrug that was approved by the US FDA in 1997 and quickly supplanted ticlopidine as the primary drug therapy for reducing atherothrombotic events. It is converted to its ... -
The role of bile acids during cholestasis in mice and man
(University of Kansas, 2015-05-31)Cholestasis is a reduction in bile flow that occurs during numerous pathologies. Cholestasis leads to significant liver toxicity, biliary hyperplasia, and liver cirrhosis. The molecular mechanisms behind the early liver ... -
SYSTEM-DEPENDENT METABOLISM OF DRUGS BY CYTOCHROME P450: THE MECHANISTIC BASIS FOR WHY HUMAN LIVER MICROSOMES ARE SUPERIOR TO HUMAN HEPATOCYTES AT METABOLIZING MIDAZOLAM BUT INFERIOR AT METABOLIZING DESLORATADINE
(University of Kansas, 2015-05-31)In the pharmaceutical industry, pooled human liver microsomes (HLM) and pooled cryopreserved human hepatocytes (CHH) are the most commonly used test systems to measure the in vitro metabolic intrinsic clearance (CLint) of ... -
Arsenic Toxicity and Altered Mitochondrial Bioenergetics in Response to Oxidative Stress
(University of Kansas, 2015-05-31)Environmental exposure to arsenic is a worldwide health concern which is linked to a number of diseases. Areas with arsenic levels above the current safe concentration have higher levels of skin, lung, liver, and bladder ... -
ROLE OF BILE ACIDS AND FARNESOID X RECEPTOR IN HEPATIC AUTOPHAGY AND ITS IMPLICATIONS IN ETHANOL-INDUCED HEPATOTOXICITY
(University of Kansas, 2014-12-31)Retention of bile acids (BAs) in the liver during cholestasis plays an important role in the development of cholestatic liver injury. Several studies have reported that high concentrations of certain BAs induce cell death ... -
Early growth response (Egr)-1: A novel anti-fibrotic mediator in liver
(University of Kansas, 2014-12-31)Chronic alcohol consumption can lead to an aberrant wound healing response of the liver, or hepatic fibrosis. Egr-1 is an essential regulator of many genes involved in the orchestration of tissue injury and repair, yet the ... -
WITHAFERIN A: A NOVEL THERAPEUTIC APPROACH FOR MALIGANT BRAIN TUMORS
(University of Kansas, 2014-08-31)High-grade gliomas, including the astrocytoma glioblastoma multiforme (GBM), are the most common adult primary malignant brain tumor. The mean post-diagnosis survival time of patients with GBM is approximately 14 months ... -
Role of Hepatocyte Nuclear Factor 4 alpha in Hepatocyte Proliferation
(University of Kansas, 2014-05-31)Hepatocyte Nuclear Factor 4 alpha (HNF4α) is the master regulator of hepatocyte differentiation. It is involved in the up-regulation of genes involved in many classic hepatic functions including: bile acid metabolism, ... -
XENOBIOTIC REGULATION OF THE ATP BINDING CASSETTE TRANSPORTER ABCB6 AND ITS SIGNIFICANCE TO HEPATIC HEME HOMEOSTASIS
(University of Kansas, 2013-12-31)Heme is indispensable for mammalian life. It is an essential component of numerous heme proteins, with functions including oxygen transport and storage, energy metabolism, drug and steroid metabolism and signal transduction. ... -
Small Molecule Hsp90 Modulator and Neuregulin-induced Peripheral Demyelination
(University of Kansas, 2012-08-31)Abstract Modulating molecular chaperones is emerging as an attractive approach to treat neurodegenerative diseases associated with protein aggregation, diabetic peripheral neuropathy (DPN) and possibly, demyelinating ... -
Cannabinoid Regulation of Serotonin 2A (5-HT<sub>2A</sub>) Receptor Signaling
(University of Kansas, 2013-08-31)Accumulating evidence indicates that sustained cannabinoid agonist exposure may precipitate the onset of some neuropsychiatric disorders that are associated with dysfunction of serotonin 2A (5-HT2A ) receptor neurotransmission ... -
EFFECTS OF A UNILATERAL INTRASTRIATAL 6-HYDROXYDOPAMINE MODEL OF EARLY PARKINSON'S DISEASE ON MIDBRAIN DOPAMINE NEURONS IN RATS: A STEREOLOGICAL STUDY
(University of Kansas, 2013-08-31)Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by loss of dopaminergic function, leading to the classical clinical signs of tremor, bradykinesia and loss of postural balance. These motor ... -
N-3 FATTY ACIDS AND JUVENILE TRAUMATIC BRAIN INJURY: EFFECTS OF DIETARY N-3 FATTY ACID CONTENT, N-3 FATTY ACID STATUS, AND ORALLY DOSED FISH OIL ON SENSORIMOTOR AND BIOCHEMICAL OUTCOMES
(University of Kansas, 2013-08-31)Children under five years of age are at high risk for sustaining traumatic brain injury (TBI) and tend to have poorer outcomes despite greater neuroplasticity in children. Hence, there is a great need to study TBI specifically ... -
Acetaminophen Hepatotoxicity in Humans and Mice
(University of Kansas, 2013-05-31)Acetaminophen (APAP) is a popular analgesic and antipyretic. Most of a therapeutic dose is glucuronidated or sulfated and excreted. A small amount is converted by cytochromes P450 to the reactive electrophile N-acetyl-p- ... -
Targeting Organic Anion Transporting Polypeptides in Cancer to Improve Diagnostics and Therapy
(University of Kansas, 2012-08-12)Organic Anion Transporting Polypeptides (OATPs) are multispecific transport proteins that mediate the uptake of numerous endogenous and exogenous compounds into cells. Recently, OATPs have been shown to have altered ...