Pharmacy Dissertations and Theses
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Bioenergetic Regulation of Neuronal Vacuolar-type H+- ATPase
(University of Kansas, 2019-12-31)Neuronal vacuolar-type H+-ATPase (V-ATPase) is an ATP-dependent proton pump that functions to acidify intracellular organelles such as lysosomes and synaptic vesicles, creating a proton gradient by which neurotransmitters ... -
Receptor for advanced glycation endproducts (RAGE) modulates glyoxalase-1 enzyme activity in mouse models.
(University of Kansas, 2019-12-31)Alzheimer’s disease (AD) is the most common cause of dementia in the world. AD is characterized pathologically by the presence of Amyloid-β (Aβ) plaques and tau neurofibrillary tangles (NFTs). Advanced glycation endproducts ... -
Respiratory chain deficiency alters cellular proteostasis and triggers Alzheimer’s disease-like tau alterations
(University of Kansas, 2019-12-31)Sporadic Alzheimer’s disease (AD) is defined clinically as a progressive brain disorder resulting in memory loss and, eventually, an inability to perform simple tasks. Pathologically, AD brains accumulate insoluble protein ... -
Role of Autophagy in Alcohol-induced Adipose Atrophy and Liver Injury
(University of Kansas, 2018-12-31)Alcoholic liver disease (ALD) is a worldwide health issue claiming 2 million lives per year. The pathogenesis of ALD is characterized by steatosis, alcoholic hepatitis, fibrosis, cirrhosis, and eventually hepatocellular ... -
The Role of Mitochondrial ATP-Binding Cassette Transporter ABCB6 in Metabolism and Energy Balance
(University of Kansas, 2019-05-31)Abstract Obesity and the associated health risks represent a world-wide health and financial crisis. Lack of physical activity combined with excessive caloric intake are the root cause of the problem. Despite the increased ... -
MECHANISMS OF CYST GROWTH AND FIBROSIS IN CONGENITAL HEPATIC FIBROSIS IN AUTOSOMAL RECESSIVE POLYCYSTIC KIDNEY DISEASE
(University of Kansas, 2018-08-31)Autosomal recessive polycystic kidney disease (ARPKD) is a rare genetic disorder that occurs in 1:20,000 live births. Patients present with a broad spectrum of symptoms involving the kidneys, liver, and pancreas. Renal ... -
A Longitudinal View of How Noise-Induced Hearing Loss Impacts Auditory and Non- Auditory CNS Activity and the Relationship to Tinnitus Behavior
(University of Kansas, 2018-08-31)Tinnitus, defined as the perception of sound when no corresponding external sound is present, affects 50 million people in the United States with 2 million reporting decreased quality of life. Although the etiology of ... -
Role of HNF4a in Liver Regeneration, Liver Cancer Pathogenesis and Global Metabolism
(University of Kansas, 2018-12-31)Liver is the central metabolic organ and performs many functions necessary for survival. Hepatocyte Nuclear Factor 4 alpha (HNF4a) is a nuclear receptor well characterized for its role in embryonic hepatocyte differentiation ... -
Characterization of SUMOylation of 5-HT1ARs
(University of Kansas, 2019-08-31)Serotonin 1A receptors (5-HT1AR) are G-protein coupled receptors involved in the control of mood, cognition and memory. Clinical and animal studies have demonstrated that abnormal levels of 5-HT1AR lead to anxiety-like and ... -
The Combined Effects of Arsenite and Ethanol on Brain Endothelial Cells and Microglial Cells
(University of Kansas, 2019-08-31)Arsenic (As) is a natural compound widely distributed in air, water, and soil. Drinking ground water is the major source of As exposure. As exposure causes many health issues, including nausea, vomiting, pain, diarrhea, ... -
The interaction between MsrA and Csn5/Jab1
(University of Kansas, 2019-08-31)Oxidative stress can cause toxic outcomes to cells/organisms’ survival. To counter this toxicity, multiple cellular mechanisms were evolved. Among them is the methionine sulfoxide reductase (Msr) system. Methionine sulfoxide ... -
The effect of irrelevant visual experience on visual memory
(University of Kansas, 2019-08-31)Consolidation of memories for long term storage involves increases in excitatory synaptic strength and connectivity between neurons encoding a novel experience. The increase in neuronal excitability caused by memory ... -
Dorsal Cochlear Nucleus Synaptic Reorganization as a Consequence of Noise-Induced Tinnitus: Increases in Somatosensory Influence on Auditory Circuitry
(University of Kansas, 2016-12-31)Tinnitus is the perception of sound with no corresponding external stimulus. It is estimated that at least 17 million Americans experienced approximately 5 minutes of acute tinnitus in the past year, and at least 10 million ... -
Cyclophilin D as a potential therapeutic target for Alzheimer’s disease
(University of Kansas, 2019-05-31)Alzheimer’s disease (AD) is the sixth leading cause of death in United States, affecting more than five million people every year. Despite substantial research into the topic, including over a hundred thousand research ... -
Modulating Molecular Chaperones to Treat Demyelinating Neuropathies
(University of Kansas, 2018-08-31)Peripheral neuropathies can be classified into two categories, demyelinating or axonal neuropathy. Demyelinating neuropathies are characterized by damaged myelin but intact axons. Recent evidence suggests that the leucine ... -
ApoE2-Mediated Neuroprotective Mechanism Through Up-regulation of Glycolysis
(University of Kansas, 2018-08-31)Studies presented here aim at gaining an insight into mechanisms of how human apolipoprotein E (ApoE) isoforms impact glucose metabolism, particularly through regulation of glycolysis, which may ultimately result in ... -
Mechanistic Studies on Arsenic Toxicity in Endothelial Cells
(University of Kansas, 2018-08-31)Arsenic is a well-established human toxin. Over 200 million people worldwide are exposed to arsenic, mainly through drinking water. Recently, several epidemiological studies have reported that even low concentrations of ... -
5α-reductase isoenzymes mediate stress-exacerbated Tourette-like responses in animal models
(University of Kansas, 2018-05-31)Tourette syndrome is a neurodevelopmental disorder characterized by purposeless, uncontrollable muscle movements known as tics. These tics are extremely sensitive to environmental factors, especially psychosocial stress. ... -
A FRET-Based approach to study the SUMOylation of Serotonin 1A Receptors
(University of Kansas, 2018-08-31)Serotonin 1A receptors are an inhibitory G-protein coupled receptor that are known to play a key role in the regulation of mood and cognition. Dysregulation of serotonin 1A receptors has been implicated in mood related ... -
Retinoic Acid Plays Critical Roles in the Late Development of the Heart
(University of Kansas, 2017-12-31)Vitamin A, via its active metabolite retinoic acid (RA), actively participates in many biological processes including cardiogenesis. Yet RA was found to be highly teratogenic as both excess and deficiency of this critical ...