Chemistry Dissertations and Theses: Recent submissions
Now showing items 21-40 of 335
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I. Hydrogenation studies on Reissert compounds. II. Synthesis of some hexadecanes and octadecanes
(University of Kansas, 1952-08-31) -
Some sulfanilamide derivatives
(University of Kansas, 1942-08-31)The preparation and the study of some sulfanilamide derivatives was begum because of the great progress in chemotherapy now being made, and the usefulness of the sulfa compounds especially, in combating various forms of ... -
Hybrid antimalarials; the reaction of 8-amino-quinolines with nitrodiols
(University of Kansas, 1950-05-31) -
Iodination of hydroxy derivatives of diphenyl ether
(University of Kansas, 1937-05-31) -
Mechanisms of Condensed Phase Reactions: The Role of Structure, Dynamics, and Environment in Photoisomerization and Photodissociation
(University of Kansas, 2019-08-31)Light-activated chemistry begins with the excitation of a ground-state molecule to a higher-lying excited state. Once in the excited state, the nuclei in the molecule respond by trying to minimize the energy of the system. ... -
Quantitative Methods to Determine Brain Deposition of Peptides and Proteins after Delivery across the Blood-Brain Barrier
(University of Kansas, 2019-08-31)It is very challenging to develop peptide and protein drugs for treatment of brain diseases because it is difficult to deliver them to the brain due to the presence of the blood-brain barrier (BBB). Therefore, there is an ... -
Analyzing Extracellular Vesicles as Potential Biomarkers of Stroke Using Polymer Microfluidic Devices
(University of Kansas, 2019-08-31)A major drawback of currently available stroke diagnosis methods, such as computed tomography (CT) and magnetic resonance (MRI), is that they cannot provide timely diagnosis within the narrow therapeutic time window of 4.5 ... -
Development and Application of Computational Tools to Study Optical Rotation of Chiral Molecules in Isotropic Media
(University of Kansas, 2019-12-31)The study of optically active molecules has been continuous for over two centuries, due to the role chiral molecules play as both the building blocks of life, and therefore their importance in developing pharmaceuticals. ... -
Surface Immobilization and Electrochemical Studies of Molecular Lanthanide and Actinide Complexes
(University of Kansas, 2019-05-31)Due to their unique properties and emerging applications in materials, the chemistry of the lanthanides and actinides has become a thriving area of research. While much work has been done to probe the electronic, magnetic, ... -
Theoretical and Experimental Development of Bipolar Based Fluorescence Detection for Microchip Electrophoresis
(University of Kansas, 2019-05-31)Abstract Methods for the separation and detection of reactive oxygen and nitrogen species (RNOS) at the cellular level can be useful tools for the study of the biochemical mechanisms of neurodegenerative diseases. Microchip ... -
Analysis of Glycopeptides by HPLC MS and Detection of Leukemic Cells by Microfluidics using Time Delayed Integration Spectral Flow Cytometry
(University of Kansas, 2019-05-31)Protein glycosylation drives many biological processes and serves as marker for disease; therefore, the development of tools to study glycosylation is an essential and growing area of research. Mass spectrometry can be ... -
Materials for Molecular Electronics Devices: Anchoring Azulene Derivatives to A Gold Surface via Molecular Self-Assembly
(University of Kansas, 2019-05-31)The use of molecular electronics to build nano-scale devices is potentially applicable to the development of electronic components, such as wires, switches, or diodes. The work described herein involves the self-assembly ... -
Metal-Templated Assembly of Heterocyclic Rings via Nucleophilic Cyclization of Cyclopropenes
(University of Kansas, 2019-05-31)This thesis is focused on the development and application of methods for the intramolecular nucleophilic addition of tethered nucleophiles to cyclopropenes. Addition of carbon-, nitrogen, and oxygen-nucleophiles was ... -
Kinetic, Spectroscopic, and Computational Insight into the Proton-Coupled Electron Transfer Reactivity of Manganese Complexes Supported by Pentadentate Ligands
(University of Kansas, 2018-12-31)In biological systems, manganese enzymes have been shown to perform vital proton-coupled electron transfer (PCET) reactions. In manganese lipoxygenase, a mid-valent MnIII-hydroxo moiety is proposed to abstract a hydrogen ... -
Direct and Indirect Probing of Higher-Lying Excited-States of Photoactive Molecules
(University of Kansas, 2018-12-31)It is often assumed that optically accessible excited-states above S1 play only a marginal role in the photochemistry and photodynamics of molecular systems. However, many classes of molecules have been found in which the ... -
Characterization and Thermodynamic Analysis of a Series of MnIII-OH Complexes that undergo Hydrogen Atom Transfer Reactions
(University of Kansas, 2018-12-31)Abstract Mononuclear MnIII-hydroxo motifs employ hydrogen atom transfer (HAT) reactions in biology and synthetic systems to oxidize a wide range of CH or OH bonds. Extensive studies on high valent Fe and Mn model systems ... -
The Design and Synthesis of β-Keto Vinyl Sultams and Macrocyclic β-Keto Vinyl Sultams: Novel Analogs of Tetramic Acids
(University of Kansas, 2018-08-31)Sulfur (S)-containing heterocyclic compounds possessing R1R2N–SO2R3 functionality have been recognized as important due to their innate physical properties that affect biological systems marking them as attractive targets ... -
Kinetic and Spectroscopic Investigation of Structural Influences on Hydrogen-atom Transfer Reactivity of N5-Ligated Oxomanganese(IV) Complexes
(University of Kansas, 2018-05-31)High valent iron- and manganese-oxo intermediates perform important hydrogenatom transfer (HAT) reactions in both biological and synthetic systems. There has been extensive characterization of HAT reactivity of enzymatic ... -
Synthesis and Characterization of Antigen-Containing Bioconjugates Used to Probe and Modulate Autoimmunity
(University of Kansas, 2018-12-31)Autoimmune diseases afflict a significant part of the world population and current treatments only treat symptoms or delay the progression of the disease. In the first chapter of this dissertation, an introduction into ...