Chemistry Scholarly Works: Recent submissions
Now showing items 281-300 of 629
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Single molecule probes of membrane structure: Orientation of BODIPY probes in DPPC as a function of probe structure
(Royal Society of Chemistry, 2013-03-21)Single molecule fluorescence measurements have recently been used to probe the orientation of fluorescent lipid analogs doped into lipid films at trace levels. Using defocused polarized total internal reflection fluorescence ... -
Microchip Electrophoresis with Amperometric Detection Method for Profiling Cellular Nitrosative Stress Markers
(Royal Society of Chemistry, 2015-07-07)The overproduction of nitric oxide (NO) in cells results in nitrosative stress due to the generation of highly reactive species such as peroxynitrite and N2O3. These species disrupt the cellular redox processes through the ... -
Software for Automated Interpretation of Mass Spectrometry Data from Glycans and Glycopeptides
(Royal Society of Chemistry, 2014-05-21)The purpose of this review is to provide those interested in glycosylation analysis with the most updated information on the availability of automated tools for MS characterization of N-linked and O-linked glycosylation ... -
Integration of Microsphere Resonators with Bioassay Fluidics for Whispering Gallery Mode Imaging
(Royal Society of Chemistry, 2014-06-07)Whispering gallery mode resonators are small, radially symmetric dielectrics that trap light through continuous total internal reflection. The resonant condition at which light is efficiently confined within the structure ... -
Development of an On-animal Separation-based Sensor for Monitoring Drug Metabolism in Freely Roaming Sheep
(Royal Society of Chemistry, 2016-06-07)The development of an on-animal separation-based sensor that can be employed for monitoring drug metabolism in a freely roaming sheep is described. The system consists of microdialysis sampling coupled directly to microchip ... -
Recent advances in the analysis of therapeutic proteins by capillary and microchip electrophoresis
(Royal Society of Chemistry, 2015-07-08)The development of therapeutic proteins and peptides is an expensive and time-intensive process. Biologics, which have become a multi-billion dollar industry, are chemically complex products that require constant observation ... -
Determination of Methylarginines in Infant Plasma by CE-LIF
(Royal Society of Chemistry, 2015-06-21)Methylarginines (MAs) are a class of nitric oxide synthase inhibitors that have been implicated in respiratory complications of critically ill infants. This paper describes the development of an analytical method to measure ... -
Synthesis of an Isoindoline-Annulated, Tricyclic Sultam Library via Microwave-Assisted, Continuous-Flow Organic Synthesis (MACOS)
(Thieme Publishing, 2012-07-04)A microwave-assisted, continuous-flow organic synthesis (MACOS) protocol for the synthesis of an isoindoline-annulated, tricyclic sultam library, utilizing a Heck–aza-Michael (HaM) strategy, is reported. This sequence ... -
Application of a Double Aza-Michael Reaction in a ‘Click, Click, Cy-Click’ Strategy: From Bench to Flow
(Thieme Publishing, 2011-03-18)The development of a ‘click, click, cy-click’ process utilizing a double aza-Michael reaction to generate functionalized 1,2,5-thiadiazepane 1,1-dioxides is reported. Optimization in flow, followed by scale out of the ... -
Synthesis of Chiral Nonracemic Tertiary α-Thio and α-Sulfonyl Acetic Esters via SN2 Reactions of Tertiary Mesylates
(Thieme Publishing, 2009-09-08)Syntheses of enantioenriched sulfides and sulfones via substitution of tertiary mesylate with thiolate nucleophile were achieved with modest to excellent success. -
Catalytic Intermolecular Hydroamination of Vinyl Ethers
(Thieme Publishing, 2009-07-30)This manuscript details the development of a palladium-catalyzed hydroamination of vinyl ethers. It is proposed that palladium catalyzes the hydroamination via Brønsted base catalysis, where palladium is protonated by the ... -
Solute location in a nanoconfined liquid depends on charge distribution
(AIP Publishing, 2015-07)Nanostructured materials that can confine liquids have attracted increasing attention for their diverse properties and potential applications. Yet, significant gaps remain in our fundamental understanding of such nanoconfined ... -
A graph-theoretical representation of multiphoton resonance processes in superconducting quantum circuits
(Nature Publishing Group, 2016-11-21)We propose a graph-theoretical formalism to study generic circuit quantum electrodynamics systems consisting of a two level qubit coupled with a single-mode resonator in arbitrary coupling strength regimes beyond rotating-wave ... -
Unravelling the dynamical origin of below- and near-threshold harmonic generation of H2+ in an intense NIR laser field
(Nature Publishing Group, 2016-11-24)Recently, the study of near- and below- threshold regime harmonics as a potential source of intense coherent vacuum-ultraviolet radiation has received considerable attention. However, the dynamical origin of these lower ... -
Native Conformation and Canonical Disulfide Bond Formation Are Interlinked Properties of HIV-1 Env Glycoproteins
(Science Publications, 2016-03)We investigated whether there is any association between a native-like conformation and the presence of only the canonical (i.e., native) disulfide bonds in the gp120 subunits of a soluble recombinant human immunodeficiency ... -
Influences on the Design and Purification of Soluble, Recombinant Native-Like HIV-1 Envelope Glycoprotein Trimers
(Science Publications, 2015-08-26)We have investigated factors that influence the production of native-like soluble, recombinant trimers based on the env genes of two isolates of human immunodeficiency virus type 1 (HIV-1), specifically 92UG037.8 (clade ... -
Comparative Analysis of the Glycosylation Profiles of Membrane-Anchored HIV-1 Envelope Glycoprotein Trimers and Soluble gp140
(Science Publications, 2015-05-27)The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) trimer, which consists of the gp120 and gp41 subunits, is the focus of multiple strategies for vaccine development. Extensive Env glycosylation ... -
Recent advances in the discovery and design of multicomponent reactions for the generation of small-molecule libraries
(Dove Medical Press, 2015-09-04)The current drug discovery process is dependent on the ability of synthetic chemistry to deliver libraries of small molecules with ever increasing levels of structural complexity and diversity. Sequencing multicomponent ... -
Assessment of low-scaling approximations to the equation of motion coupled-cluster singles and doubles equations
(American Meteorological Society, 2014)Methods for fast and reliable computation of electronic excitation energies are in short supply, and little is known about their systematic performance. This work reports a comparison of several low-scaling approximations ... -
A time-dependent polarizable continuum model: Theory and application
(AIP Publishing, 2005)This work presents an extention of the polarizable continuum model to explicitly describe the time-dependent response of the solvent to a change in the solute charge distribution. Starting from an initial situation in which ...