Chemistry Scholarly Works: Recent submissions
Now showing items 161-180 of 629
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MAPping the Chiral Inversion and Structural Transformation of a Metal-Tripeptide Complex having Ni-SOD Activity
(American Chemical Society, 2011-03-21)The metal abstraction peptide (MAP) tag is a tripeptide sequence capable of abstracting a metal ion from a chelator and binding it with extremely high affinity at neutral pH. Initial studies on the nickel-bound form of the ... -
Embedding the Ni-SOD mimetic Ni-NCC within a polypeptide sequence alters specificity of the reaction pathway
(American Chemical Society, 2013-01-07)The unique metal abstracting peptide (MAP) asparagine-cysteine-cysteine (NCC) binds nickel in a square planar 2N:2S geometry and acts as a mimic of the enzyme nickel superoxide dismutase (Ni-SOD). The Ni-NCC tripeptide ... -
Controlling the Chiral Inversion Reaction of the Metallopeptide Ni-Asparagine-Cysteine-Cysteine with Dioxygen
(American Chemical Society, 2012-09-17)Synthetically generated metallopeptides have the potential to serve a variety of roles in biotechnology applications, but the use of such systems is often hampered by the inability to control secondary reactions. We have ... -
A novel tripeptide model of nickel superoxide dismutase
(American Chemical Society, 2010-01-18)Nickel superoxide dismutase (Ni-SOD) catalyzes the disproportionation of superoxide to molecular oxygen and hydrogen peroxide, but the overall reaction mechanism has yet to be determined. Peptide-based models of the 2N:2S ... -
Synthesis of a Library of 1,5,2-Dithiazepine 1,1-Dioxides. Part 2: Routes to Bicyclic Sultams
(Elsevier, 2012-12-31)The synthesis of a library of bicyclic sultams incorporating the 1,5,2-dithiazepine 1,1-dioxide moiety is reported. Following scaffold synthesis via a one-pot sulfonylation/intramolecular thia-Michael protocol, several ... -
Synthesis of a Library of 1,5,2-Dithiazepine 1,1-Dioxides. Part 1: A One-Pot Sulfonylation/Thia-Michael Protocol
(Elsevier, 2012-12-31)A novel one-pot sulfonylation/intramolecular thia-Michael protocol is reported for the synthesis of 1,5,2-dithiazepine 1,1-dioxides. Sulfonylation between cysteine ethyl ester/cysteamine and 2-chloroethanesulfonyl chloride, ... -
Fluorescence quenching studies of structure and dynamics in calmodulin-eNOS complexes
(Wiley, 2015-05-08)Activation of endothelial nitric oxide synthase (eNOS) by calmodulin (CaM) facilitates formation of a sequence of conformational states that is not well understood. Fluorescence decays of fluorescently labeled CaM bound ... -
Divalent and Multivalent Activation in Phosphate Triesters: A Versatile Method for the Synthesis of Advanced Polyol Synthons
(Wiley, 2009-11)The construction of mono- and bicyclic phosphate trimesters possessing divalent and multivalent activation and their subsequent use in the production of advanced polyol synthons is presented. The method highlights efforts ... -
Absolute Quantitation of Glycosylation Site Occupancy Using Isotopically Labeled Standards and LC-MS
(American Chemical Society, 2014-06)N-linked glycans are required to maintain appropriate biological functions on proteins. Underglycosylation leads to many diseases in plants and animals; therefore, characterizing the extent of glycosylation on proteins is ... -
Two separate gene clusters encode the biosynthetic pathway for the meroterpenoids, austinol and dehydroaustinol in Aspergillus nidulans
(American Chemical Society, 2012-03-14)Meroterpenoids are a class of fungal natural products that are produced from polyketide and terpenoid precursors. An understanding of meroterpenoid biosynthesis at the genetic level should facilitate engineering of ... -
The structure of the BfrB-Bfd complex reveals protein-protein interactions enabling iron release from bacterioferritin
(American Chemical Society, 2012-08-15)Ferritin-like molecules are unique to cellular iron homeostasis because they can store iron at concentrations much higher than those dictated by the solubility of Fe3+. Very little is known about the protein interactions ... -
Structural, NMR Spectroscopic and Computational Investigation of Hemin Loading in the Hemophore HasAp from Pseudomonas aeruginosa
(American Chemical Society, 2010-07-21)Heat shock protein 90 (Hsp90) inhibition by modulation of the N-or C-terminal binding site has become an attractive strategy for the development of anti-cancer chemotherapeutics. The first Hsp90 C-terminus inhibitor, ... -
Stereospecific decarboylative allylation of sulfones
(American Chemical Society, 2010-09-08)Allyl sulfonyl acetic esters undergo highly stereospecific, palladium-catalyzed decarboxylative allylation. The reaction allows the stereospecific formation of tertiary homoallylic sulfones in high yield. In contrast to ... -
Formation of N-Alkylpyrroles via Intermolecular Redox Amination
(American Chemical Society, 2009-11-25)Redox isomerization reactions are of particular interest because they exhibit perfect atom economy, and they often utilize the inherent reducing power of hydrogen that is embedded in molecules to effect reduction of other ... -
Decarboxylative Benzylations of Alkynes and Ketones
(American Chemical Society, 2010-07-14)Utilization of palladium π-benzyl complexes in cross-coupling reactions is becoming increasingly important in organic synthesis.1 However, methods for benzylic cross-couplings typically rely on the use of basic reagents ... -
Deacylative allylation: allylic alkylation via retro-Claisen activation
(American Chemical Society, 2011-09-21)A new method for allylic alkylation of a variety of relatively non-stabilized carbon nucleophiles is described herein. In this process of “deacylative allylation” the coupling partners, an allylic alcohol and a ketone ... -
Dual catalytic decarboxylative allylations of α-amino acids and their divergent mechanisms
(Wiley, 2015-12-14)The room temperature radical decarboxylative allylation of N-protected α-amino acids and esters has been accomplished via a combination of palladium and photoredox catalysis to provide homoallylic amines. Mechanistic ... -
Synthesis of 1,5-Dioxocanes via the Two-Fold C-O Bond Forming Nucleophilic 4+4-Cyclodimerization of Cycloprop-2-en-1-ylmethanols
(Royal Society of Chemistry, 2015-08-19)An efficient [4+4] cyclodimerization of cyclopropenemethanols operating via a two-fold strain release-driven addition of alkoxides across the double bond of cyclopropenes was investigated. This chemo- and diastereoselective ... -
LC–MS/MS determination of carbamathione in microdialysis samples from rat brain and plasma
(Elsevier, 2010-01-05)A selective liquid chromatography–tandem mass spectrometric (LC–MS/MS) method was developed for the determination of S-(N, N-diethylcarbamoyl) glutathione (carbamathione) in microdialysis samples from rat brain and plasma. ... -
Palladacycles: Effective Catalysts for a Multicomponent Reaction with Allylpalladium(II)-Intermediates
(Elsevier, 2012-03-01)Palladium(II) complexes with an auxiliary bidentate ligand featuring one C-Pd bond and a Pd-N-donor bond (palladacycles) have been shown to afford improved yields of homoallylic amines from a three-component coupling of ...