Pharmacy, School of: Recent submissions
Now showing items 341-360 of 417
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Cannabinoid Regulation of Serotonin 2A (5-HT<sub>2A</sub>) Receptor Signaling
(University of Kansas, 2013-08-31)Accumulating evidence indicates that sustained cannabinoid agonist exposure may precipitate the onset of some neuropsychiatric disorders that are associated with dysfunction of serotonin 2A (5-HT2A ) receptor neurotransmission ... -
EFFECTS OF A UNILATERAL INTRASTRIATAL 6-HYDROXYDOPAMINE MODEL OF EARLY PARKINSON'S DISEASE ON MIDBRAIN DOPAMINE NEURONS IN RATS: A STEREOLOGICAL STUDY
(University of Kansas, 2013-08-31)Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by loss of dopaminergic function, leading to the classical clinical signs of tremor, bradykinesia and loss of postural balance. These motor ... -
N-3 FATTY ACIDS AND JUVENILE TRAUMATIC BRAIN INJURY: EFFECTS OF DIETARY N-3 FATTY ACID CONTENT, N-3 FATTY ACID STATUS, AND ORALLY DOSED FISH OIL ON SENSORIMOTOR AND BIOCHEMICAL OUTCOMES
(University of Kansas, 2013-08-31)Children under five years of age are at high risk for sustaining traumatic brain injury (TBI) and tend to have poorer outcomes despite greater neuroplasticity in children. Hence, there is a great need to study TBI specifically ... -
Acetaminophen Hepatotoxicity in Humans and Mice
(University of Kansas, 2013-05-31)Acetaminophen (APAP) is a popular analgesic and antipyretic. Most of a therapeutic dose is glucuronidated or sulfated and excreted. A small amount is converted by cytochromes P450 to the reactive electrophile N-acetyl-p- ... -
Targeting Organic Anion Transporting Polypeptides in Cancer to Improve Diagnostics and Therapy
(University of Kansas, 2012-08-12)Organic Anion Transporting Polypeptides (OATPs) are multispecific transport proteins that mediate the uptake of numerous endogenous and exogenous compounds into cells. Recently, OATPs have been shown to have altered ... -
Pharmacological Induction of Molecular Chaperones Restores Mitochondrial Function in Hyperglycemically Stressed Sensory Neurons
(University of Kansas, 2012-12-31)Distal diabetic peripheral polyneuropathy (DPN) is a prevalent complication resulting from chronic hyperglycemia in diabetic patients. It is associated with incapacitating pain, foot ulceration, and lower-limb amputations ... -
Role of Coagulation in Xenobiotic-Induced Liver Injury
(University of Kansas, 2012-08-31)The liver is a common target for xenobiotic-induced toxicity. Of importance, synthesis of soluble coagulation factors by the liver plays an essential role in hemostasis. Blood coagulation cascade activation is evident in ... -
Role of Interleukin-1beta and neutrophil activation during acetaminophen overdose
(University of Kansas, 2012-08-31)Acetaminophen (APAP) overdose is the leading cause of acute liver failure in the US. APAP is metabolized to a reactive metabolite that causes hepatotoxicity in a dose-dependent manner. A series of cascading intracellular ... -
THE ROLE OF NRF2 IN PREVENTING OXIDATIVE/ELECTROPHILIC STRESS-INDUCED LIVER INJURY
(University of Kansas, 2012-08-31)Redox maintenance is critical for all biological species. Amplification of mechanisms that reduces oxidative/electrophilic stress promotes health and extends life. Nuclear factor, erythroid derived 2, like 2 (Nrf2) is a ... -
Neuronal Protection by a Novel C-terminal Hsp90 Modulator
(University of Kansas, 2012-08-31)Alzheimer's disease (AD), like most neurodegenerative disorders, is characterized by accumulation of misfolded and aggregated proteins, indicating that the protein quality control machinery is compromised. Enhancing the ... -
Effects of the Over-Expression of Neuronal Glutamate Dehydrogenase (Glud1) on Mouse Brain Mitochondrial Function
(University of Kansas, 2012-08-31)Glutamate has been shown to lead to neurotoxicity and subsequent neurodegeneration through changes in synaptic function, loss of glutamatergic neurons, synapses, and dendrites. All of these characteristics are also observed ... -
Intracellular drug distribution-based targeting: Exploiting lysosomes to enhance the selectivity of drugs towards cancer cells
(University of Kansas, 2012-08-31)Under the most ideal circumstances, anticancer agents should be minimally toxic to normal cells and maximally noxious to cancer cells. Unfortunately, an optimal degree of selectivity is not typically achieved and chemotherapy ... -
Investigating the Aggregation of the Basic Leucine Zipper (bZIP) Domain of Activating Transcription Factor 5 (ATF5)
(University of Kansas, 2010-05-31)Protein aggregation is a major problem for biopharmaceuticals. Aggregate formation in a drug formulation can have serious health implications for the patient. While the control of protein aggregation is critically important ... -
FEXOFENADINE AND ORGANIC ANION TRANSPORTING POLYPEPTIDES (OATPs): TRANSPORT AND DRUG-DRUG INTERACTIONS
(University of Kansas, 2011-12-31)Transporters play a major role in the absorption and disposition of fexofenadine, suggesting this drug could be used as a probe of transporter activity. When fexofenadine was administered in combination with four drugs ... -
Substrate Dependent Alterations of Organic Anion Transporting Polypeptide 1B3 (OATP1B3)
(University of Kansas, 2011-12-31)Organic anion transporting polypeptides (OATPs) are multispecific transporters that mediate the uptake of numerous drugs and xenobiotics into cells. Alterations in the function of the liver–specific OATP1B1 and OATP1B3 ... -
REGULATION OF DRUG METABOLISM AND INFLAMMATION BY PREGNANE X RECEPTOR
(University of Kansas, 2011-12-31)Liver-enriched nuclear receptor (NR) proteins regulate the expression and activity of several pivotal hepatic biochemical pathways including the uptake, metabolism and excretion of cholesterol, bile acids, glucose, and ... -
Management of Hallucinations and Psychosis in Parkinson's Disease
(Elsevier, 2010-08)BACKGROUND: Hallucinations and psychosis are common in patients with Parkinson's disease (PD), with reported prevalences of up to 48% and 80%, respectively. However, few randomized, double-blind, placebo-controlled trials ... -
Development of Biomarkers Based on Diet-Dependent Metabolic Serotypes: Characteristics of Component-Based Models of Metabolic Serotypes
(Mary Ann Liebert, Inc., 2004)Our research seeks to identify a scrum profile, or serotype, that reflects the systemic physiologic modifications resultant from dietary restriction (DR), in part such that this knowledge can be applied for biomarker ... -
Development of Biomarkers Based on Diet-Dependent Metabolic Serotypes: Concerns and Approaches for Cohort and Gender Issues in Serum Metabolome Studies
(Mary Ann Liebert, Inc., 2004)Mathematical models that reflect the effects of dietary restriction (DR) on the sera metabolome may have utility in understanding the mechanisms of DR and in applying this knowledge to human epidemiological studies. Previous ... -
Development of Biomarkers Based on Diet-Dependent Metabolic Serotypes: Practical Issues in Development of Expert System-Based Classification Models in Metabolomic Studies
(Mary Ann Liebert, Inc., 2004)Dietary restriction (DR)-induced changes in the serum metabolome may be biomarkers for physiological status (e.g., relative risk of developing age-related diseases such as cancer). Megavariate analysis (unsupervised ...