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Chemistry: Recent submissions
Now showing items 861-880 of 964
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Intramolecular oxa-Michael and Baylis Hillman Strategies towards Sultam Libraries
(University of Kansas, 2011-05-31)The utilization of Baylis-Hillman and oxa-Michael methodologies for the synthesis of sultam (cyclic sulfonamides) libraries from chiral non-racemic amino alcohols and epoxides is reported. These strategies employ a divergent ... -
Spectroscopic and Computational Studies of the Physical Properties and Reactivities of Peroxomanganese(III) Complexes
(University of Kansas, 2011-05-31)A wide range of MnIII intermediates were generated and studied using various spectroscopic techniques, including electronic absorption, magnetic circular dichroism (MCD), variable-temperature, variable-field (VTVH) MCD, ... -
Development of Methods for the Heteroatom Functionalization of Cyclopropenes
(University of Kansas, 2011-08-31)The main focus of this thesis is the stereoselective funtionalization of cyclopropenes mainly via the addition of H-X (hetroatom-hydrogen) moieties across the strained double bond. It is broken up into three chapters, each ... -
Investigations into Protein-Surface Interactions via Atomic Force Microscopy and Surface Plasmon Resonance
(University of Kansas, 2012-08-31)Protein surface interactions are important in many diverse applications. In this dissertation nonspecific and specific interactions of two proteins (fibrinogen and F1-ATP synthase) with a variety of surfaces have been ... -
Self-Assembly of Azulenic Monolayer Films on Metallic Gold Surfaces
(University of Kansas, 2012-08-31)Derivatives of azulene, an unusual nonbenzenoid aromatic hydrocarbon featuring fused five- and seven-membered sp2 carbon rings, are of substantial current interest in the design of advanced functional materials such as ... -
CHARACTERIZATION OF THE STRUCTURE AND REACTIVITY OF A NICKEL(II)-TRIPEPTIDE MIMIC OF NICKEL SUPEROXIDE DISMUTASE
(University of Kansas, 2012-08-31)The tripeptide asparagine-cysteine-cysteine (NCC) was found by the J. Laurence lab to bind nickel very tightly. In fact, NCC was serendipitously discovered as a metal-abstraction peptide tag (MAP-tag) because it was stripping ... -
Qualitative and quantitative analysis of proteolytically digested glycoproteins by mass spectrometry
(University of Kansas, 2011-05-31)Glycoproteins are a very large and biologically relevant class of proteins that comprise more than 50 % of proteins in the human body. The glycosylation present on proteins, specifically N-linked glycosylation has been ... -
Structure/Function Relationships in Nickel-Peptide Complexes: Impact of the Primary Coordination Sphere on Square-Planar Nickel Chemistry
(University of Kansas, 2011-05-31)The novel metal-binding tripeptide asparagine-cysteine-cysteine (NCC) is capable of coordinating a metal ion, and we are exploring its use in several biological applications. Different metals may be incorporated into this ... -
Dopamine Release and Uptake in Animal Models of Neurological Diseases
(University of Kansas, 2011-5-31)Fast scan cyclic voltammetry (FSCV) can be utilized to detect neurotransmitter release and uptake in brain slices. When combining this technique with disease state animals models, information for therapeutic targets can ... -
Synthesis and Coordination Chemistry of Azulene- and Ferrocene-Based Isocyanide Ligands
(University of Kansas, 2011-08-31)Nonbenzenoid aromatic isocyanides feature attractive structural and electronic properties for the potential design of optoelectronic devices. Prior to the work of Barybin and coworkers, examples of nonbenzenoid isocyanides ... -
Therapeutic Protein and Glycoprotein Production, Optimization, and Analysis Methods
(University of Kansas, 2010-05-31)Proteins and glycoproteins have the potential to improve health when used as therapeutic products for prevention or treatment of disease, but methods are needed for solving some remaining challenges to production, optimization, ... -
PROGRESS IN DEVELOPING AN OVARIAN CANCER SCREEN BASED ON WHISPERING GALLERY MODE IMAGING
(University of Kansas, 2012-05-31)Despite considerable research devoted to identifying biomarkers for ovarian cancer, no screening method is currently available for routine early detection of the disease. While highly treatable in its early stages, a lack ... -
Palladium-catalyzed allylic alkylation via decarboxylative and retro-Claisen C-C cleavage methods
(University of Kansas, 2012-05-31)Presented herein is the development of new methods for Pd-catalyzed allylic alkylation with a central focus on reactions that generate molecular complexity rapidly with little waste byproduct. With this simply stated, yet ... -
Newly Developed Methods for Functionalization of Quaternary Carbons: Decarboxylative Allylation, Benzylation, and Arylation of Nitriles and the Asymmetric Baeyer-Villiger Oxidation of 1,3-Diketones
(University of Kansas, 2012-05-31)Decarboxylative carbon-carbon bond formations have emerged as a powerful synthetic tool within the past ten years. Beginning with the seminal reports from Saegusa and Tsuji in 1980, the decarboxylative allylation (DcA) of ... -
Syntheses of Functionalized Benzylic Compounds: Development of Palladium-Catalyzed Decarboxylative Benzylation Reactions
(University of Kansas, 2012-08-31)Carbon-carbon bond formation between the benzyl carbon and a functional group is important in organic synthesis because majority of the compounds in the chemical literature contain aromatic cores appended with different ... -
Iron metabolism in the opportunistic pathogen Pseudomonas aeruginosa requires two ferritin-like molecules, Pa FtnA and Pa BfrB
(University of Kansas, 2012-08-31)FtnA is an iron storage protein in Pseudomonas aeruginosa which is capable of storing about 4500 Fe3+ ions in its inner core. According to earlier classifications of this protein Pseudomonas aeruginosa was proposed to have ... -
Constructivist-Based Asynchronous Tutorial to Improve Transfer between Math and Chemistry Domains: Design, Implementation, and Analysis of the Impact of ReMATCH on General Chemistry Course Performance and Confidence
(University of Kansas, 2011-12-31)The two-year implementation of ReMATCH, a web-based math and problem-solving tutorial, in a traditionally arranged general chemistry classroom at the University of Kansas examined the impact of a designed intervention to ... -
Investigations into the Chemistry of Laundering
(University of Kansas, 1910) -
The Optical Properties of Some Petroleum Products
(University of Kansas, 1913-05-15) -
The effect of temperature, acid concentration and time on the bromination of phenol for quantitative determinations
(University of Kansas, 1913-01-15)