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    Dopamine Release and Uptake in Animal Models of Neurological Diseases

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    Fulks_ku_0099D_11538_DATA_1.pdf (4.874Mb)
    Issue Date
    2011-5-31
    Author
    Fulks, Jenny Lynn
    Publisher
    University of Kansas
    Format
    144 pages
    Type
    Dissertation
    Degree Level
    Ph.D.
    Discipline
    Chemistry
    Rights
    This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
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    Abstract
    Fast scan cyclic voltammetry (FSCV) can be utilized to detect neurotransmitter release and uptake in brain slices. When combining this technique with disease state animals models, information for therapeutic targets can be obtained. Herein, the evaluation of stimulated dopamine release and uptake in animal models was used in conjunction with pharmacological agents to assess neurological problems caused by Fragile X syndrome and chemotherapy. Fragile X Syndrome, a genetic form of mental retardation caused by a trinucleotide repeat expansion, was investigated by combining behavioral analysis and FSCV to determine alterations in dopamine release, dopamine uptake, effects of amphetamine treatments, and the functionality of the D2 autoreceptor. Side effects of chemotherapy can include alteration in neurological function and were investigated by using FSCV to monitor for effect on dopamine release and uptake patterns in the striatum of rats being dosed with Carboplatin, a chemotherapeutic drug. Finally, instrumentation was established to use caged compounds to photo release glutamate while collecting FSCV data of dopamine release to evaluate instantaneous effects of glutamate on the dopamine system in brain slices.
    URI
    http://hdl.handle.net/1808/10427
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    • Chemistry Dissertations and Theses [336]
    • Dissertations [4475]

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    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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