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Chemistry: Recent submissions
Now showing items 841-860 of 964
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Identification and analysis of hepatitis C virus NS3 helicase inhibitors using nucleic acid binding assays
(Oxford University Press, 2012-06-27)Typical assays used to discover and analyze small molecules that inhibit the hepatitis C virus (HCV) NS3 helicase yield few hits and are often confounded by compound interference. Oligonucleotide binding assays are examined ... -
P20-08. Glycosylation: an important factor in Env diversity
(BioMed Central, 2009-10-22) -
Function Annotation of Hepatic Retinoid x Receptor α Based on Genome-Wide DNA Binding and Transcriptome Profiling
(Public LIbrary of Science, 2012-11-15)Background Retinoid x receptor α (RXRα) is abundantly expressed in the liver and is essential for the function of other nuclear receptors. Using chromatin immunoprecipitation sequencing and mRNA profiling data generated ... -
Envelope Deglycosylation Enhances Antigenicity of HIV-1 gp41 Epitopes for Both Broad Neutralizing Antibodies and Their Unmutated Ancestor Antibodies
(Public Library of Science, 2011-09-01)The HIV-1 gp41 envelope (Env) membrane proximal external region (MPER) is an important vaccine target that in rare subjects can elicit neutralizing antibodies. One mechanism proposed for rarity of MPER neutralizing antibody ... -
Stabilizing Exposure of Conserved Epitopes by Structure Guided Insertion of Disulfide Bond in HIV-1 Envelope Glycoprotein
(Public Library of Science, 2013-10-13)Entry of HIV-1 into target cells requires binding of the viral envelope glycoprotein (Env) to cellular receptors and subsequent conformational changes that culminates in fusion of viral and target cell membranes. Recent ... -
Automated Builder and Database of Protein/Membrane Complexes for Molecular Dynamics Simulations
(Public Library of Science, 2007-09-12)Molecular dynamics simulations of membrane proteins have provided deeper insights into their functions and interactions with surrounding environments at the atomic level. However, compared to solvation of globular proteins, ... -
Phosphate Tether-Mediated Synthetic Studies- Applications in Natural Products Synthesis.
(University of Kansas, 2012-08-31)The focus of this dissertation is the utilization of phosphate tether mediated approaches to synthesize bioactive natural products and their analogs in аn efficient and effective manner. The several salient features, which ... -
Symmetry-Defying Iron Pyrite (FeS2) Nanocrystals through Oriented Attachment
(Nature Publishing Group, 2013-06-28)Iron pyrite (fool's gold, FeS2) is a promising earth abundant and environmentally benign semiconductor material that shows promise as a strong and broad absorber for photovoltaics and high energy density cathode material ... -
Synthetic Approaches to Skeletally Diverse Sultams Using Vinyl- and α-Halo Benzenesulfonamides
(University of Kansas, 2012-08-31)The development of new chemical methods to generate novel and diverse structures to probe chemical space is an important aspect of early phase drug discovery. Diversity-Oriented Synthesis (DOS) is a powerful strategy that ... -
Determination of Lipid Peroxidation Associated with a Focal Seizure Model through In Vivo Microdialysis Sampling
(University of Kansas, 2013-05-31)Two methods were developed to evaluate the extent of lipid peroxidation in an animal model of focal seizures. Microdialysis was used to sample from the extracellular fluid in specific regions of the hippocampus. The first ... -
Conformational Analysis of Disordered Proteins Using H/D Exchange Mass Spectrometry
(University of Kansas, 2013-05-31)Intrinsically disordered proteins (IDPs) represent a growing area of scientific interest. The prevalence of IDPs within the proteomes of complex organisms and the importance of these proteins in cellular functions has ... -
Strain-Release Activation of α,β-Unsaturated Amides Towards Conjugate Addition of N, O and S - Nucleophiles
(University of Kansas, 2013-05-31)This thesis encompasses a novel methodology enabling the diastereoselective addition of heteroatom-centered nucleophiles to the conjugated double bond of in situ-generated α,β - unsaturated cyclopropenyl amides. The ... -
Development of Dual-Electrode Amperometric Detectors for Liquid Chromatography and Capillary Electrophoresis
(University of Kansas, 2013-05-31)Abstract The body of this research was focused on the use and development dual-electrode detection schemes for liquid chromatography and capillary electrophoresis. These detection schemes were developed to investigate redox ... -
STRATEGIC COMBINATION OF TRANSITION METAL-CATALYZED REACTIONS FOR ECONOMICAL ONE-POT SYNTHESES OF N-HETEROCYCLES
(University of Kansas, 2013-08-31)There has been extraordinary progress in the field of chemical synthesis over the last couple of decades. Innovative methodologies and robust catalysts are emerging. Propelled by all these inventions the evolution of the ... -
Development of an Analytical Method for the Detection and Quantitation of Nitrite as a Biomarker of Nitric Oxide and Reactive Nitrogen Species in Biological Samples
(University of Kansas, 2013-05-31)Sean D. Willis, MS Department of Chemistry, December 2012 University of Kansas The brain is a complex organ, consisting of blood vessels, neurons, neuronal support cells, and meninges. The extracellular space surrounding ... -
Programmable active droplet generation enabled by integrated pneumatic micropumps
(RSC Publishing, 2013)In this work we have investigated the integrated diaphragm micropump as an active fluidic control approach for the on-demand generation of droplets with precisely defined size, frequency and timing. In contrast to ... -
Carbon Dioxide Fixation in Cultured Animal Cells
(University of Kansas, 1969) -
Reorientation and Solvation Dynamics of Bulk and Confined Alcohols
(University of Kansas, 2012-12-31)Reorientation and solvation dynamics play a central role in chemistry in the liquid phase. In this work, molecular dynamics simulations are used to study hydroxyl group reorientation dynamics for a series of neat linear ... -
Synthetic Entries Into the Bicyclo[2.1.1]Hexane System
(University of Kansas, 1974)